EFFECT OF BINARY BLEND OF VEHICLES ON THE PHYSICAL PROPERTIES OF DIRECTLY COMPRESSED DIIODOQUIN TABLETS

Document Type : Original Article

Authors

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Abstract

Directly compressible vehicles such as Avicel, Emdex, Sugratab, Anhydrous Lactose U.S.P, STA-R 1500 starch and Fmcompress, were used either singly or in binary blends in the ratios of 1:1, 1:3 and 3:1 w/w for the preparation diiodoquin tablets.
Avicel, Celutab and STA-Rx 1500 starch were found to be the most suitable single vehicles for the formulation of diiodoquin tablets. Tablets produced using STA-R and its blends with the other vehicles, disintegrated within the specified time. The best blends used for the manufacturing of directly compressed diiodoquin tablets were those containing avicel/STA-Rx 1500 starch 3:1 and 1:3. The least actual concentration of the vehicle needed for the preparation of good diiodoquin tablets was not  less than 42.0% w/w.