Document Type : Original Article
Authors
1
Biochemistry Department Faculty of Veterinary Medicine, Zagazig University, Egypt
2
Departments of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, 44519, Zagazig, Egypt/ Laboratories of Biotechnology, Faculty of Veterinary Medicine, Zagazig University, 44519, Zagazig, Egypt
3
Department of Animal Physiology and Biochemistry, Faculty of Veterinary Medicine, Badr University in Cairo (BUC), Badr City, Cairo, Egypt/ Departments of Physiology, Faculty of Veterinary Medicine, Zagazig University, 44519, Zagazig, Egypt
4
Bachelor of pharmacy, Zagazig University ,Egypt
Abstract
The present study investigates the anti-inflammatory, analgesic effect, and gastric disturbance of curcumin compared with celecoxib and prednisolone. Sixty male rats divided into (Group 1 and G2: control, G3, G4, and G5: orally received celecoxib, prednisolone, and curcumin respectively then received carrageenan in paw after 14 days. Edema, oxidative markers, analgesic, ulcerogenic activity, skin expression of (nuclear factor kappa-β (NF-kappaβ), tumor necrosis factor-alpha (TNF-α), Interleukin-1β (IL1β), IL 6 and IL 10) and gastric mRNA expression of (Heme oxygenase-1 (HO-1), interleukin 8 (IL8), nuclear factor erythroid 2-related factor 2 (Nrf2), NFκβ and Superoxide dismutase (SOD)) were measured. This result revealed that curcumin significantly improved edema, ulcerogenic, analgesic activity, and oxidative markers like celecoxib and prednisolone effect when compared with carrageenan. Curcumin significantly downregulated mRNA expression of the inflammatory markers of skin and gastric mucosae like celecoxib and prednisolone effect when compared with carrageenan. Curcumin, celecoxib, and prednisolone significantly upregulated skin (IL10) compared with carrageenan. Curcumin significantly upregulated Ho-1, SOD, and Nrf2 compared with carrageenan, celecoxib, and prednisolone. Based on the above it could conclude that curcumin displayed anti-inflammatory and analgesic with minimum gastric disturbance, unlike celecoxib and prednisolone.
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