NEUROPROTECTIVE EFFECTS OF PHYLLANTUS DEBILIS ON RAT'S HIPPOCAMPUS

Document Type : Original Article

Authors

1 School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesha, 10, Bandung, 40132, Jawa Barat, Indonesia / Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta, Indonesia

2 School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesha, 10, Bandung, 40132, Jawa Barat, Indonesia

Abstract

Phyllanthus debilis has the potential as an antioxidant and anti-inflammatory, suitable for application in neurodegenerative disorders such as cognitive impairment. This study aimed to examine the effect of P. debilis dichloromethane extract as a neuroprotector in rats treated with electroconvulsive shock (ECS). The rats were given the test substances for  20 days p.o, and ECS induction was held from day 15 to day 19. The Morris water maze (MWM) test determined the cognitive function, while hippocampus homogenates were used for biochemical studies. P. debilis showed the ability to reduce cognitive impairment in ECS-induced rats. The biochemical tests on the rat hippocampus showed a significant increase in catalase (CAT) activity and lipid peroxidase inhibition. The results aligned with anti-inflammatory activity, where TNF-α concentration showed significantly lower results than the ECS control. Overall results demonstrated the ability of P. debilis as a neuroprotective agent through the reduction of oxidative stress and inflammation.

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