Zinc oxide nanoparticles (ZnO NPs) have gained a huge interest as a promising therapeutic alternative for antibiotics. In this study, the biosynthesis of ZnO NPs was performed using Aloe vera leaves extract in a remarkably simple approach. The biosynthesized ZnO NPs were detected by UV-Vis spectrophotometer at wavelength of 383 nm. The x-ray diffraction analysis indicated the hexagonal wurtzite of ZnO NPs with a median crystallite size of 16.7 nm. Transmission and scanning electron microscopy exhibited the hexagonal shape of ZnO NPs with a median particle size of ~ 20 nm. Fourier transform infrared analysis showed the mutual presence of phenolic compounds in Aloe vera leaves extract and ZnO NPs which reflected their principle role in the bio-reduction. From our perspective, the optimum conditions for the biosynthesis of ZnO NPs with smaller sizes included zinc nitrate concentration of 0.01-0.03M, Aloe vera extract concentration of 50%, pH=8, and 25-40 ̊C. The antibacterial impact of ZnO NPs was confirmed against both Gram-negative and Gram-positive bacterial isolates. Values of minimum inhibitory concentration (MIC) of ZnO NPs varied to be 2-4.1 mg/ml and 8.2-11 mg/ml for Gram-negative and Gram-positive bacterial isolates, respectively. Furthermore, ZnO NPs exhibited bactericidal impact on all tested bacterial isolates with minimum bactericidal concentration (MBC) of 2.1-4.7 mg/ml and 8.2-11.4 mg/ml for Gram-negative and Gram-positive bacterial isolates, respectively.
Abu-Gharbia, M., Salem, J., & Al-Arabi, G. (2023). Biosynthesis of Zinc Oxide Nanoparticles Using Aloe vera Leaves Extract and Their Antibacterial Impact. Bulletin of Pharmaceutical Sciences Assiut University, (), -. doi: 10.21608/bfsa.2023.239425.1934
MLA
Magdy Abu-Gharbia; Jehan Salem; Gehad Al-Arabi. "Biosynthesis of Zinc Oxide Nanoparticles Using Aloe vera Leaves Extract and Their Antibacterial Impact". Bulletin of Pharmaceutical Sciences Assiut University, , , 2023, -. doi: 10.21608/bfsa.2023.239425.1934
HARVARD
Abu-Gharbia, M., Salem, J., Al-Arabi, G. (2023). 'Biosynthesis of Zinc Oxide Nanoparticles Using Aloe vera Leaves Extract and Their Antibacterial Impact', Bulletin of Pharmaceutical Sciences Assiut University, (), pp. -. doi: 10.21608/bfsa.2023.239425.1934
VANCOUVER
Abu-Gharbia, M., Salem, J., Al-Arabi, G. Biosynthesis of Zinc Oxide Nanoparticles Using Aloe vera Leaves Extract and Their Antibacterial Impact. Bulletin of Pharmaceutical Sciences Assiut University, 2023; (): -. doi: 10.21608/bfsa.2023.239425.1934