ADVANCES AND DEVELOPMENTS IN DRUG REPURPOSING; STATE OF ART

Noori, Sarmad Dheyaa; Al-Hamdani, Mais Mazin; Kassem, Amira B

doi:10.21608/bfsa.2023.327668

ADVANCES AND DEVELOPMENTS IN DRUG REPURPOSING; STATE OF ART

Document Type : Review Article

Authors

¹ Department of pharmaceutical chemistry- College of Pharmacy - Al-Ayen University

² Department of Pharmaceutics, College of Pharmacy , Al-Ayen University

³ Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Damnhour University Department of Clinical Pharmacy, Collage of Pharmacy, Al-Ayen University

10.21608/bfsa.2023.327668

Abstract

Although the rapid progress in science and technology, developing new drugs from scratch has been expensive in recent decades. As a result, drug-repurposing, which implies seeking new utilizes for presently approved drugs instead of discovering new drug compounds, has emerged as a substitution tool to speed up the drug development procedure. Nowadays, drug repurposing accounts for 30% of newly approved drugs. With the explosive growth of pharmacological compounds' molecular, genomic, and phenotypic data, a novel area of drug repurposing called computational drug repurposing has emerged. This review provides an overview of recent progress in computational drug repurposing, including repositioning approaches, commonly used computational methods, validation techniques for repurposing studies, and the remaining encounters in computational repurposing. In this Review, we outline methods for drug repurposing (also known as drug repositioning), talk about difficulties encountered by the repurposing community, and suggest creative solutions to these issues. addressed to aid in maximising the benefits of medicinal repurposing.