The release rate of progesterone, dexamethasone, ethinylestradiol and a-methyldopa(MD) was determined in aqueous gels of pluronic surfactants (F-65, F-127, F-123) and the effects of concentration and temperature were investigated. The release of drugs from pluronic F-127 could be described by the diffusional model and the rate-controlling stage in the release process is diffusion of the dispersed drug through the matrix continuum. The release-rate decreased as the concentration of pluronic F-127 increased for both dexamethasone and progesterone; and increased as the molecular weight of the pluronic type increased (F-65 < F-123 < F-127) for ethinylestradiol. While, the release rate of a-methyldopa(MD) dexamethasone and ethinylestradiol decreased as increasing concentration of the drug and increasing the temperature, we found that increasing progesterone concentration and temperature;increased the release rate.
Safwat, S. (1994). DRUG RELEASE FROM PLURONIC GELS. Bulletin of Pharmaceutical Sciences Assiut University, 17(1), 41-48. doi: 10.21608/bfsa.1994.69786
MLA
Salwa M. Safwat. "DRUG RELEASE FROM PLURONIC GELS". Bulletin of Pharmaceutical Sciences Assiut University, 17, 1, 1994, 41-48. doi: 10.21608/bfsa.1994.69786
HARVARD
Safwat, S. (1994). 'DRUG RELEASE FROM PLURONIC GELS', Bulletin of Pharmaceutical Sciences Assiut University, 17(1), pp. 41-48. doi: 10.21608/bfsa.1994.69786
VANCOUVER
Safwat, S. DRUG RELEASE FROM PLURONIC GELS. Bulletin of Pharmaceutical Sciences Assiut University, 1994; 17(1): 41-48. doi: 10.21608/bfsa.1994.69786
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