Hydroxyzine is a piperazine derivative recommended for treatment of anxiety. The drug was formulated in suppository forms using different types of fatty, emulsion and water soluble bases. Non ionic surfactants as well as aerosils were used as formulating additives. The drug release from the formulating bases as well as the tranquilizing potency in mice were evaluated. It was found that formulations which afford the higher release rates in the in-vitro study, give also the more pronounced tranquilizing effect in the animal testing.
Habib, F., Sayed, H., Ismail, S., Gomea, A., & Shaker, A. (1990). PREPARATION AND EVALUATION OF HYDROXYZINE SUPPOSITORIES. Bulletin of Pharmaceutical Sciences Assiut University, 13(2), 265-280. doi: 10.21608/bfsa.1990.70586
MLA
F. S. Habib; H. A. Sayed; S. Ismail; A. A. Gomea; A. Shaker. "PREPARATION AND EVALUATION OF HYDROXYZINE SUPPOSITORIES". Bulletin of Pharmaceutical Sciences Assiut University, 13, 2, 1990, 265-280. doi: 10.21608/bfsa.1990.70586
HARVARD
Habib, F., Sayed, H., Ismail, S., Gomea, A., Shaker, A. (1990). 'PREPARATION AND EVALUATION OF HYDROXYZINE SUPPOSITORIES', Bulletin of Pharmaceutical Sciences Assiut University, 13(2), pp. 265-280. doi: 10.21608/bfsa.1990.70586
VANCOUVER
Habib, F., Sayed, H., Ismail, S., Gomea, A., Shaker, A. PREPARATION AND EVALUATION OF HYDROXYZINE SUPPOSITORIES. Bulletin of Pharmaceutical Sciences Assiut University, 1990; 13(2): 265-280. doi: 10.21608/bfsa.1990.70586
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