THE USE OF HPLC-CYCLOBOND COLUMN FOR QUANTITATIVE DETERMINATION OF ANTICATARRHAL TABLETS
S.
El-Gizawy
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Assiut University, Assiut, Egypt
author
A.
Ahmed
Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy Assiut University, Assiut, Egypt
author
M.
Makboul
Department of Pharmacognosy, Faculty of Pharmacy Assiut University, Assiut, Egypt
author
text
article
1991
eng
The utility of high performance liquid chromatography cyclobond-I column for the separation and analysis of paracetamol, phenylpropanolamine HCl and chlorpheniramine maleate in synthetic mixture was clearly demonstrated using mobile-phase methanol: phosphate buffer pH 7.0 (10:90), flow rate 0.8 ml min-1 and the detection was affected spectrophotometrically at 254 nm. Adequate sensitivity and an excellent' precision were obtained for the determination of the commercial dosage form.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
14
v.
1
no.
1991
1
5
https://bpsa.journals.ekb.eg/article_70369_26695201335bd41c1dae9197bb51e49c.pdf
dx.doi.org/10.21608/bfsa.1991.70369
EFFECT OF SUSPENDING AGENTS ON THE DISSOLUTION AND BIOAVAILABILITY OF AMPICILLIN
A.
Bosela
Department of Pharmaceutics, Al-Fateh University, Tripoli, Libya
author
M.
Treki
Department of Pharmaceutics, Al-Fateh University, Tripoli, Libya
author
M.
Mahdy
Department of Pharmaceutics, Al-Fateh University, Tripoli, Libya
author
M.
Mohamed
Department of Pharmaceutics, Al-Fateh University, Tripoli, Libya
author
text
article
1991
eng
The effect of various suspending agents viz., Methyl cellulose, Sodium carboxymethyl cellulose, Bentonite and polyvinylpyrrolidone on the dissolution of ampicillin from its suspensions was studied. Methyl cellulose (MC) gave the best ampicillin suspensions as indicated by the highest sedimentation volume (F=0.78) while polyvinylpyrrolidone (PVP) gave the poorest suspensions (F=0.11). The effectiveness of the suspending agents decreased in the following order: MC > Bentonite > Sod. CMC > PVP. The in-vitro dissolution studies showed that all the suspending agents decreased the dissolution rate of the drug. As the suspending agents concentration was increased, the retardation effect on drug dissolution increased. The bioavailability of ampicillin from its suspensions was studied in 6 healthy volunteers by urinary excretion method. Commercial product (Penbritin) was included for comparison. Both % dose excreted and maximum excretion rate were markedly reduced except' in suspension containing Sod. CMC. However, the time for maximum excretion was not affected.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
14
v.
1
no.
1991
6
12
https://bpsa.journals.ekb.eg/article_70370_3b0556c26b99019787a74b3ec7b72f34.pdf
dx.doi.org/10.21608/bfsa.1991.70370
FORMULATION AND EVALUATION OF CLOTRIMAZOLE OINTMENT
S.
Ibrahim
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
E.
Hafez
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
S.
El-Shanawany
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
E.
Abdel-Magid
Department of Dermatology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
E.
El-Gibaly
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1991
eng
The in vitro release of clotrimazole from different ointment bases was studied. The bases tested were oleagenous, absorption, water-soluble, an O/W emulsion and a W/O emulsion ointment base. The release profile agreed with the first order mechanism. Among the tested bases, the water soluble base provided the best release rate.
Clotrimazole exhibited antimycotic effect against C. albicans. 'The data had confirmed the in-vitro release results and proved the superiority of the water soluble bases.
The clinical evaluation was performed on patients complaining of T. circinata. Three ointment formulations of different release pattern Viz; waters soluble, O/W emulsion and an oleagenous ointment each incorporating 1% clotrimazole, were selected to conduct the clinical test. Good efficacy was obtained with 1% clotrimazole in water soluble base composed of PEG 4000 and PEG 400 (4:6).
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
14
v.
1
no.
1991
13
22
https://bpsa.journals.ekb.eg/article_70371_90a94985943f25337fd63d40001647a0.pdf
dx.doi.org/10.21608/bfsa.1991.70371
STUDY OF THE EFFECT OF VERAPAMIL, CHLORDIAZEPOXIDE AND THEIR COMBINATION ON SPONTANEOUS LOCOMOTOR ACTIVITY IN MICE
M.
Abdel-Rahman
Department of Pharmacology, Faculty of Medicine, Assiut university, Assiut, Egypt
author
text
article
1991
eng
The effects of verapamil, ch1ordiazepoxide (CDX) separately or and in combination on spontaneous locomotor activity (SLMA) of mice were investigated using an activity cage apparatus. Results of the present study revealed that the i.p. injection of verapamil in three dose levels(0.3, 0.6 and 1.3 mg/kg) elicited a dose dependent decrease, both in intensity and duration, of SLMA of mice. The i.p. administration of CDX in doses of 5 and 10 mg/kg brought about a significant dose-related diminution of SLMA of mice. Verapamil, in its three levels, administered concurrently with CDX., in its two dose levels, resulted in a significant potentiation of CDX- induced inhibition of SLMA. However, This potentiation caused by verapamil was much more evident with the smaller dose level of CDX (5mg/kg), than with the higher dose level (10 mg/kg).
Available reports are in agreement with our results. These reports indicate that verapamil might have the ability to suppress ALMA of mice'· and to potentiate the CDX-induced inhibition of SLMA via different mode of action.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
14
v.
1
no.
1991
23
34
https://bpsa.journals.ekb.eg/article_70372_270602a4a54d128fe3e26df5198b1cd9.pdf
dx.doi.org/10.21608/bfsa.1991.70372
FACTORS AFFECTING CHLORDIAZEPOXIDE SOLUBILIZATION BY NON-IONIC SURFACTANTS
A.
Abdel Rahman
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
A.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
E.
Samy
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1991
eng
Ceratain factors affecting chlordiazepoxide solubilization in series of non-ionic surfactant solutions were investigated viz., surfactant structure, the pH, the temperature and the incorporation of certain hydroxylated organic additives.
Polysorbate 80 was more efficient for the drug solubilization than polysorbate 20 and Brij 35 was more efficient than Brij 58. On the other hand Eumulgin C1000 was found to be more efficient than Eumulgin C1500 and Myrj 52 was more than Myrj 53 than Myrj 59.
Increasing the pH of Eumulgin and Brij solutions caused a gradual decrease in the quantity of the drug solubilized.
Nukerjee treatment was adopted to quantify the role of both the core and capsular regions of Myrj micelles in solubilizing the drug.
The drug was solubilized in Eumulgin and Brij series containing 5 or 10% w/v propylene glycol, glycerol, PEG 400 and PEG 4000. Brij 35 containing 5% w/v propylene glycol was the most efficient solubilizer for chlordiazepoxide.
The distribution coefficient, Km, of the drug between the micellar and aqueous phases was calculated.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
14
v.
1
no.
1991
35
45
https://bpsa.journals.ekb.eg/article_70373_bca652aa539a3d0ce2d76c699d52e683.pdf
dx.doi.org/10.21608/bfsa.1991.70373
DESIGN OF SUSTAINED RELEASE FORMULATIONS OF SALBUTAMOL I- ION-EXCHANGE RESIN SYSTEMS
H.
Sayed
Department of Pharmaceutics., Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
A.
El-Sayed
Department of Pharmaceutics., Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
A.
Osman
Department of Chest, Faculty of Medicine, Assiut University, Assiut, Egypt
author
M.
Fathy
Department of Pharmaceutics., Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1991
eng
Ion-exchange resins were used in an attempt to prepare sustained release products of salbutamol. Different types of cation-exchange resins were tested namely; Amberlite IRP-69, Amberlite IR-120, Amberlite MB-l, Amberlite CG-50 and Amberlite IRC-50. The drug was loaded onto resins using the batch process. The effect of drug concentration and the resin forms on the loading capacity of resins were tested. The drug release patterns from its resinates were studied. The release rates were too high to bring about sustained action properties. The drug resinates prepared by the use of each Amberlite IRP-69 (H+ and Na+- form) and Amberlite IR-120 (Na+-form) were subjected to coating treatment adopting emulsion-solvent evaporation microencapsulation. Cellulose acetate butyrate was used as the coating material, A sustained release formulations of the prepared· microcapsules were clinically evaluated. The treatment with the sustained release formulation given twice daily was found to be clinically the same or better than of the plain drug given three times a day.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
14
v.
1
no.
1991
46
60
https://bpsa.journals.ekb.eg/article_70374_c10fabac30ae495b638b8a75b6f3a121.pdf
dx.doi.org/10.21608/bfsa.1991.70374
DESIGN OF SUSTAINED RELEASE FORMULATIONS OF SALBUTAMOL II- CLAY SORBATE SYSTEMS
H.
Sayed
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
A.
El-Sayed
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
A.
Osman
Department of Chest, Faculty of Medicine, Assiut University, Assiut, Egypt
author
M.
Fathy
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1991
eng
Salbutamol is an effective drug in the treatment of bronchial asthma. The adsorption of salbutamol onto various clays viz., veegum HV, bentonite and magnesium trisilicate was investigated. The optimal conditions for loading the drug onto the clays were determined. The drug release from its sorbates indicates the need for a diffusion barrier to modify the drug release profile. Cellulose acetate butyrate at 1:1 core : coat ratio was used as a coating material. The coated drug sorbates offered an acceptable release profile of the drug. Coated sorbates prepared by using drug loaded onto veegum HV as the core were used to prepare a sustained release formulation of the drug. The formulation was tested in asthmatic patients and compared to the plain drug by measuring some pulmonary functions. The administration of the sustained release formulation twice daily gave the same or better improvement than that of the plain drug given three times a day.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
14
v.
1
no.
1991
61
73
https://bpsa.journals.ekb.eg/article_70375_31b3ac0d071dfc4710363a6843923cd0.pdf
dx.doi.org/10.21608/bfsa.1991.70375
A STUDY OF THE INCLUSION COMPLEX OF AMOBARBITAL WITH HEPTAKIS (2,6-DI-O-METHYL)--CYCLODEXTRIN
M.
Abd El-Mohsen
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
H.
Mohamed
Department of Analytical Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1991
eng
The inclusion complex of amobarbital, a hypnotic and sedative agent, with heptakis (2,6-di-o-methyl)-b-cyclodextrin (DMCD) in aqueous solution and in the solid phase was studied by the solubility method, UV spectroscopy, infrared spectroscopy (IR) ,differential scanning calorimetry (DSC) and X-ray diffractometry. The inclusion complex was confirmed to be 1: 1. The solid complex of amobarbital with DMCD in 1:1 molar ratio was prepared by coprecipitation method. The solubility and dissolution characteristics of the solid complex in water at 37±1 °C were examined. The complex formation constant, Kc, was calculated from the slope and intercept of the AL solubility diagram (950 M-1). The dissolution rate of amobarbital was significantly enhanced by the complexation with DMCD specially in the initial period of dissolution. The hypnotic effect of amobarbital and its complex given orally to mice was evaluated. The inclusion complex, showed a decrease in the onset of action and an increase in the duration of hypnotic effect.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
14
v.
1
no.
1991
74
81
https://bpsa.journals.ekb.eg/article_70376_0f01d6af10bfea072c52876d103f951f.pdf
dx.doi.org/10.21608/bfsa.1991.70376
FORMULATION AND EVALUATION OF SOME TOPICAL ANTIMYCOTICS 3- EFFECT OF PROMOTORS ON THE IN VITRO AND IN VIVO EFFICACY OF CLOTRIMAZOLE OINTMENT
S.
Ibrahim
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
E.
Hafez
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
S.
El-Shanawany
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
I.
El-Gibaly
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
S.
Ali
Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
text
article
1991
eng
Dimethyl sulphoxide (DMSO), linoleic acid (LOA) and propylene glycol (PG) glyceryl monostearate (GMS), dioctyl sodium sulphosuccinate and Brij 35 were tested as enhancers for clotrimazole permeation.
The results revealed that, incorporation of the tested promotors in the oleagenous base increased the in vitro release rate of the drug and also its antimycotic activity against Candida albicans. Contrast results were obtained for the water soluble base.
The amount of clotrimazole determined in rabbit skin, was more pronounced when the additives were incorporated in the water soluble base. The histological studies of rabbit skin, showed variable degrees of penetration and no harmful changes of the skin tissues were observed.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
14
v.
1
no.
1991
82
94
https://bpsa.journals.ekb.eg/article_70377_fac31e4282864a7734856479dec51360.pdf
dx.doi.org/10.21608/bfsa.1991.70377
IMPROVEMENT OF DISSOLUTION BEHAVIOR OF TEMAZEPAM
S.
Saleh
Department. of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
S.
Ahmed
Department. of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
J.
Aiache
Laboratoire de Biopharmacie, Faculte de.Pharmacie, B.P. 38, 63001 Clermont-ferrand Cedex, France
author
text
article
1991
eng
The interaction between temazepam and b-cyclodextrin (b-CD) or hydroxypropyl b-cyclodextrin (HPb-CD) was studied in aqueous solution. The attempts made to obtain temazepam-cyclodextrin complexes in the solid state through freeze drying or slow evaporation under nitrogen of equimolar solutions of temazepam-CD failed to separate these inclusion compounds. On the other hand, co-grinding of temazepam with b-CD or HPb-CD although showed no evidence of formation of inclusion complexes, yet gave rise to very fast dissolution compared to non-treated temazepam or its physical mixtures with CD. Furthermore, the co-grinding of temazepam with Avicel PH 101 (microcrystalline ,cellulose) improved temazepam dissolution to nearly the same extent as those of b-CD or HPb- CD.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
14
v.
1
no.
1991
95
102
https://bpsa.journals.ekb.eg/article_70378_414d589117bd4b3406ee6b8477624f59.pdf
dx.doi.org/10.21608/bfsa.1991.70378