FORMULATION AND EVALUATION OF CERTAIN ANTI-INFLAMMATORY DRUGS FOR TOPICAL APPLICATION. II: POLYMER FILM FORMS
S.
Safwat
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
S.
El-Shanawany
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
El-Sayed
Ibrahim
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1987
eng
The release characteristics of the nonsteroidal anti-inflammatory drugs, flufenamic and mefenamic acids from ethyl cellulose and polyvinylacetate polymeric cast films were studied.
The effect of formulation variables of the films composition viz. nonionic surfactants (Tween 80 and Span 20), and additive polymer (polypropylene glycol 2000 and polyethylene glycol 400) on the release characteristics of both drugs were also investigated. The effect of addition of hydroxypropylcellulose in different ratios to polyvinylacetate films at constant flufenamic acid concentration, on the release characteristics of the drug was also evaluated.
Further, the permeability properties of both free polymeric films for both drugs was evaluated and correlated with drug penetration through the skin of the rat, on the basis of the permeability constant and diffusion coefficient. Kinetic data analysis proved that the mechanism of release of both drugs followed a diffusion controlled model from the two polymeric films.
The release rate in pure and in mixed films was increased by Tween 80 or polyethylene glycol 400. Also release rate of flufenamic acid was increased markedly by inclusion of hydroxypropyl cellulose to polyvinylacetate film to certain extent. Flufenamic acid release rate was always higher than that of mefenamic acid from both polymers. It was found that flufenamic acid had the higher diffusion coefficient than that of mefenamic acid.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
10
v.
1
no.
1987
1
36
https://bpsa.journals.ekb.eg/article_74023_5b931a4325d736fc042521341306feeb.pdf
dx.doi.org/10.21608/bfsa.1987.74023
ESSENTIAL OIL OF PULICARIA UNDULATA L. GROWING IN EGYPT AND ITS EFFECT ON ANIMAL BEHAVIOUR
A.
Ali
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
M.
Makboul
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
M.
Assaf
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
R.
Anton
Department of Pharmacognosy, Faculty of Pharmacy, University of Louis Pasteur, Strasbourg, France
author
text
article
1987
eng
By combination of GLC and GC/MS; it was possible to analysis the composition of the essential oil obtained by steam distillation from the total parts of Pulicaria undulata L. growing in Egypt. Vineteen components were identified, the main one being carvotanacetone, linalool, benzyl acetate and piperitone. The oil has a marked sedative action on animal behavior.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
10
v.
1
no.
1987
37
49
https://bpsa.journals.ekb.eg/article_74025_d0f2de98e1a63817c5f9ddaa9bcdd375.pdf
dx.doi.org/10.21608/bfsa.1987.74025
MACRO-AND MICROMORPHOLOGY OF TABEBUIA PENTAPHYLLA HEMSL. CULTIVATED IN EGYPT. PART II: THE STEM BARK AND FLOWER
D.
Bishay
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut-Egypt
author
S.
Ross
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut-Egypt
author
A.
Abdel-Baky
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut-Egypt
author
Z.
Ibrahim
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut-Egypt
author
text
article
1987
eng
The macro-and micromorphology of the stem bark and flower of Tabebuia pentaphylla Hemsl. cultivated in Aswan botanic garden have been investigated in order to determine the diagnostic features by which each organ could be identified both in the entire and powdered forms.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
10
v.
1
no.
1987
50
73
https://bpsa.journals.ekb.eg/article_74027_3c1a2c78a68bdc6d7c547cb0dc32b65e.pdf
dx.doi.org/10.21608/bfsa.1987.74027
PHARMACOGNOSTICAL STUDY OF GYNANDROPSIS PENTAPYHLLA (HURHUR) GROWING IN EGYPT PART III: LIPIDS AND FLAVONOIDS OF THE LEAVES
A.
Ali
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
H.
Sayed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
M.
Mesbah
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt & Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Georgia University, Athens, Georgia, U.S.A.
author
text
article
1987
eng
From the air dried powdered leaves of Gynandropsis pentapyhlla (Hurhur), we isolated and identified centaureidin (5,7,3 trihydroxy, 3,6,4 trimethoxy flavone), Kaempferol, Kaempferol-3-O-diglucoside, quercitrin, myricitrin, a- and b- amyrin, taraxasterol and b-sitosterol.
The fatty acids capric, lauric, myrestic, palmitic, palmitoleic, stearic, oleic and linileic were detected and estimated.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
10
v.
1
no.
1987
74
83
https://bpsa.journals.ekb.eg/article_74030_3373761009c72a0424b2a94b02947728.pdf
dx.doi.org/10.21608/bfsa.1987.74030
PHARMACOLOGICAL EVALUATION OF SOME OXAMIDE DERIVATIVES ON CEREBRAL ACTIVITY
H.
El-Bitar
Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
R.
Abdel Aal
Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
text
article
1987
eng
The present study was adopted in an attempt to evaluate the anticonvulsant and central epressant activity of five N-substituted-N-(2-methyl-4-oxoquinazolin-3-yl) oxamides. The anticonculsant activity was determined against both electroshock and pentyleneterazole induced seizures in mice. The CNS deperessant activity was indicated by measuring their effect on the spontaneous motor activity of mice using the activity cage apparatus.
Diazepam was used in the experiments as a reference drug for comparative purpose. Results of the present study revealed that most of the compounds in question possess variable degree of anticonvulsant and CNS depressant activity and the compound N-Isopropyl-N-(2-methyl-4-0x0quinazolin-3-yl) oxamide displayed the greatest response. Intraperitoneal injection of this compound into rabbits has not led to any remarkable change in the ECG, blood pressure or respiration. However on weight basis the magnitude f diazepam response is greater than any of the tested compounds.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
10
v.
1
no.
1987
84
94
https://bpsa.journals.ekb.eg/article_74045_7fab9eed704cbe5f7425708adc99ab50.pdf
dx.doi.org/10.21608/bfsa.1987.74045
ON THE INTERACTION BETWEEN RIFAMPICIN AND MACROMOLECULES II. MYRJS AND BRIJS
S.
Ismail
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
F.
Habib
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
S.
El-Shanawany
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
E.
Fouad
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1987
eng
The permeation rate constant of rifampicin in presence of Hyrj 52, Myrj 53, Myrj 59, Brij 35 and Brij 58 was studied utilizing the dynamic dialysis technique. The presence of Myris or Brij in rifampicin solution markedly decreased the permeation rate constant. Generally, the apparent transfer rate constant is inversely proportional to the surfactant concentration. The most reducing effect was exhibited in case of Brij 35. This may be due to a high affinity of the drug to interact with this surfactant than the other tested ones.
The Langmuir plots for the interaction between rifampicin and surfactant showed g-intercept indicating that the complex formation is a factor in the binding of rifampicin by surfactants. Furthermore, the presence of surfactant in rifampicin solution was found to reduce its antibacterial activity against S. aureus.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
10
v.
1
no.
1987
95
111
https://bpsa.journals.ekb.eg/article_74047_4bee0d264bbc5094a1dfa68daa617ae8.pdf
dx.doi.org/10.21608/bfsa.1987.74047
KINETICS OF ASPRIN HYDROLYSIS IN AQUEOUS SOLUTIONS OF SURFACTANTS. III: SODIUM LAURYL SULFATE
S.
Ismail
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
A.
Simonelli
Department of Pharmaceutics, Faculty of Pharmacy, University of Connecticut , Storrs, CT. 06268, USA
author
text
article
1987
eng
The hydrolysis of aspirin solution at a variety of pH values and in presence of increasing concentrations of sodium lauryl sulfate (SLS) was investigated at 35°C. The hydrolysis followed first order kinetics. The results indicate that the presence of sodium lauryl sulfate results in a protection of aspirin against hydrolysis and the degree of protection was found to be dependent on the surfactant concentration. This finding was explained on the basis that as the surfactant concentration was increased, aspirin was distributed in a favour of the micellar phase and the amount of aspirin exists in the true aqueous phase, which is susceptible to hydrolysis, is reduced. Also, the data revealed that the presence of sodium layryl sulfate did not alter the optimum pH value for the stability of aspirin solution which was found to be 2.4.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
10
v.
1
no.
1987
112
122
https://bpsa.journals.ekb.eg/article_74048_59c7a7df6da84fe7b38d4babdc18244c.pdf
dx.doi.org/10.21608/bfsa.1987.74048
FORMULATION AND EVALUATION OF DIFFERENT CHLORDIAZEPOXIDE HYDROCHLORIDE SUPPOSITORIES
F.
Habib
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
H.
Sayed
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
S.
Ismail
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
S.
Shaker
Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
A.
Shaker
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1987
eng
Chlordiazepoxide hydrochloride (CDZ); is formulated in different suppository bases. Its in vitro release from these selected suppository bases was studied and found to be base dependent. The effect of drug concentration was also studied. The percentage of drug diffused, through cellophane membrane, increased with decreasing the drug concentration. Drug particle size was found to have an insignificant effect on the release rate.
Histological studies of the rabbit rectal mucosa after the rectal insertion of the tested suppository bases either alone or in the presence of CDZ showed insignificant histological changes.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
10
v.
1
no.
1987
123
145
https://bpsa.journals.ekb.eg/article_74050_6cd9a100a6a50ba2b0cae00d2bda8276.pdf
dx.doi.org/10.21608/bfsa.1987.74050
EVALUATION OF SOME DIFFERENT METHODS FOR THE DIAGNOSIS OF STREPTOCOCCAL INFECTION
S.
Ahmed
Department of Microbiology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
A.
El-Timawy
Department of Microbiology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
I.
Seddik
Department of Microbiology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
N.
Rashwan
Department of Microbiology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
A.
Thabet
Department of Microbiology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
text
article
1987
eng
The classical haemolytic and latex agglutination tests were used for determination of antistreptolysin O titer (ASO) in 63 patient serum samples presenting in ENT and Pediatric Departments in Assiut University Hospital. At the same time, throat swab was collected from each patient and cultured on blood agar. There was an agreement between the two serological tests in 73.33% of the cases; the remaining 26.67% of cases were only positive with haemolytic test. Therefore, the latex test may be suggested for preliminary screening of the sera before embarking on determination of ASO. From the obtained data an agreement was apparent between the haemolytic test and isolation method in 95.56% of the examined cases.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
10
v.
1
no.
1987
146
156
https://bpsa.journals.ekb.eg/article_74052_4399dc52982577ea03bea2ef1ad2a680.pdf
dx.doi.org/10.21608/bfsa.1987.74052
ALKALOIDS FROM HAEMANTHUS MULTIFLORUS MARTYN
A.
Ali
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
H.
Sayed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
O.
Abdalla
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
W.
Steglich
Institute fur Organische Chemie und Biochemie der Universitäte, Bonn, West Germany
author
E.
Dagne
Institute fur Organische Chemie und Biochemie der Universitäte, Bonn, West Germany
author
text
article
1987
eng
Phytochemical study of the alkaloidal content of Haemanthus multiflorus Martyn grown in Ethiopia, Resulted in the isolation and characterization of lycorine, in addition to galanthamine and sanguinine, are to be reported for the first time from this species.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
10
v.
1
no.
1987
157
164
https://bpsa.journals.ekb.eg/article_74054_bc69bb2bd87e86b224d25309b13749f1.pdf
dx.doi.org/10.21608/bfsa.1987.74054