EFFECT OF VARIOUS VEHICLES ON THE UNIFORMITY OF DRUG CONTENTS OF DIRECTLY COMPRESSED CHLORAMPHENICOL TABLETS
A.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
S.
Saleh
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1984
eng
Chloramphenicol tablets were prepared using various concentrations of directly compressible vehicles. It was found that Avicel and STA-Rx produced suitable Chloramphenicol tablets which comply with B.P. requirements. On the other hand Sugartab, Anhydrous lactose, Emcompress and Celutab gave rise to tablets with long disintegration time. It was found also that all the batches were uniform with regard to their drug contents except for those tablets containing different concentrations of Sugartab. This may be due the difference in the physical properties between Chloramphenicol and Sugartab powders.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
1
14
https://bpsa.journals.ekb.eg/article_89514_9260b425537e61f7bc44d45099cf0fc4.pdf
dx.doi.org/10.21608/bfsa.1984.89514
A STUDY ON THE STABILITY OF DIRECTLY COMPRESSED OXYTETRACYCLINE HYDROCHLORIDE AND DIIODOQUIN TABLETS
A.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
S.
Tout
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1984
eng
A study on the stability of directly compressed oxytetracycline hydrochloride and diiodoquin tablets was preformed. A comparison was made between diiodoquin tablets prepared by direct compression and those prepared by wet granulation. T½ was determined using the calculated rate of reaction. The tablets were stored in amber coloured bottles for different periods. It was found that directly compressed tablets were more stable than those prepared by wet granulation method.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
15
29
https://bpsa.journals.ekb.eg/article_89515_da7a33fc1f37172c2df2e5770953f5fe.pdf
dx.doi.org/10.21608/bfsa.1984.89515
DETERMINATION OF ANTAZOLINE IN DOSAGE FORMS AND WITH NAPHAZOLINE IN COMBINATION
S.
El-Shabouri
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
M.
Amer
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
A.
Taha
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
P.
Khashaba
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1984
eng
A simple and rapid spectrophotometric method is described for the determination of antazoline and naphazoline either singly or in combination. The method is based on the interaction of both drugs in the form of base with chloranil in acetonitrile at room temperature. The interaction products of antazoline and naphazoline exhibit two lmax, one at about 300 nm for both drugs and the other at 448 and 510 nm for antazoline and naphazoline respectively. Different variables have been studied to optimize the reaction conditions for both drugs. Beer's law is obeyed for both drugs over a range of 5-45 mg/ml. Interference studies are carried out and the application of this procedure for the determination of antazoline in single component tablets and in combination with naphazoline in nasal drops is given with good recovery range(99.4-99.9%). Synthetic mixtures of antazoline and naphazoline are satisfactorily analyzed simultaneously with good recoveries.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
30
46
https://bpsa.journals.ekb.eg/article_89516_6a912b3a6039c5f34a7eb2f92b3e873d.pdf
dx.doi.org/10.21608/bfsa.1984.89516
PROLONGATION OF THE RELEASE OF EPHEDRINE HYDROCHLORIDE BY THE USE OF ANIONIC ACRYLIC RESINS
A.
Nouh
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
author
M.
Kassem
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
author
Alaa
Kassem
Faculty of Pharmacy, El-Azhar University
author
G.
Elmahrouk
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
author
text
article
1984
eng
Eudragits S, L, RL and mixture of S and L were employed for prolonging the release of ephedrine hydrochloride from tablets by two different techniques, viz, spray coating and molecular dispersion. The in-vitro dissolution rate evaluation in both acid and alkaline media revealed that, tablets prepared with Eudragit-L showed the most prolonged release with t20% of 3½ and 4½ hours for spray coating and molecular dispersion methods respectively. Concerning the technique itself; drug-Eudragit molecular dispersion system showed a slower release than spray coating.
Higuchi model for drug release could be applied for the release pattern only for few hours in case of tablets containing coated drug, while it absolutely explains the release from tablets having drug-Eudragit molecular dispersion system. Release was found to proceed according to order kinetics.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
47
61
https://bpsa.journals.ekb.eg/article_89521_b1e14bcc5650f5f6493ed332aad2b89b.pdf
dx.doi.org/10.21608/bfsa.1984.89521
COLORIMETRIC DETERMINATION OF THYMOL, OXYPHENBUTAZONE AND MORPHINE HYDROCHLORIDE
S.
El-Shabouri
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
A.
Taha
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
B.
Mohamed
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1984
eng
A simple colorimetric method has been developed for the determination of thymol, oxyphenbutazone and morphine hydrochloride either in pure forms or in pharmaceutical preparations. The method is based on the formation of an azo dye from the condensation of diazotized 5-chloro-2,4-dinitroaniline with the titled drugs which contain a phenolic hydroxyl group. The absorption spectra for the coupling coloured products, for thymol, oxyphenbutazone and morphine hydrochloride exhibit absorption maxima at 592 nm (e= 46,153), 450 nm (e= 20,689) and 480 nm (e= 11,764) respectively. For each of the three studied drugs a typical calibration curve was obtained from linear regression analysis of absorbance at various drug concentrations. The developed colour for each drug was stable for at least 30 minutes. Optimum conditions for the colour formation have been determined. The application of this procedure to pharmaceutical preparations is given with good recoveries (99.69-100.50%).
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
62
74
https://bpsa.journals.ekb.eg/article_89522_c6367db7cd70a5c42b1c7f40d02af356.pdf
dx.doi.org/10.21608/bfsa.1984.89522
MANUFACTURE AND DISSOLUTION CHARACTERISTICS OF NEOMYCIN SULPHATE TABLETS
M.
Kassem
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
author
M.
El-Khatib
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
author
text
article
1984
eng
Some direct compression vehicles, viz., Avicel PH 101, Celutab, Sta-Rx 1500 Starch, Emcomress, and Solka-floc were employed in different concentrations for the preparation of neomycin sulphate tablets. The physical properties of the produced tablets were determined. The effect of incorporation of the different excipients on the dissolution characteristics of neomycin sulphate have been investigated. Neomycin sulphate tablets were successfully prepared by mixing with the suggested vehicles and drying before compression. Of the used vehicles, Celutab and Emcompress proved to be the best in improving the mechanical properties of the produced tablets. This improvement increased on increasing the proportion of the excipient. On the other hand, Avicel in spite of producing tablets having high hardness and low friability values, extended the disintegration time of the tablets. The drug dissoluted from these tablets very rapidly, but the rate decreased on increasing Avicel proportion.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
75
96
https://bpsa.journals.ekb.eg/article_89530_e3473ceaeb06e988efa99ae02fb8d5ee.pdf
dx.doi.org/10.21608/bfsa.1984.89530
EFFECT OF SOME HYDROXYLATED ADDITIVES ON THE MICELLAR SOLUBILIZATION OF METHOTRIMEPRAZINE
A.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
M.
Mesiha
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
A.
Abdel-Zaher
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1984
eng
The effect of different hydroxylated compounds on the solubility of Methotrimeprazine in non-ionic surfactant solutions was investigated at two different temperatures. Ethanol, glycerol, polyethylene glycol (PEG) 600 and PEG 4000, mannitol and sorbitol were studied as additives in systems containing Eumulgin C 1000, Eumulgin C 1500, Brij 35 and Brij 58 as the solubilizing surfactants.
Micellar solubilization of Methotrimeprazine was found to be increased in Brij 35 systems with all additives except at low concentration (5% w/v) of PEG 600. It also increased in systems of Brij 58 containing PEG 600, PEG 4000, mannitol and sorbitol.
A marked decrease in micellar solubilization of the drug was effected in systems of Eumulgine and Brij-58 containing ethanol or glycerol due to decreased micellization. Also, PEG 4000, mannitol and sorbitol decreased solubilizing effect of Eumulgine, except for PEG 4000 with Eumulgin C1000 at 35°.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
97
108
https://bpsa.journals.ekb.eg/article_89533_372e2044b9ddaf8c8912e0635fbdb18b.pdf
dx.doi.org/10.21608/bfsa.1984.89533
RETARDATION OF NITROFURANTOIN RELEASE BY COACERVATION
M.
Mesiha
Departments of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
H.
El-Sourady
Departments of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1984
eng
Gelatin-acacia coacervation was employed to microencapsulate paraffin oil and soft paraffin droplets containing suspended nitrofurantoin, and for direct encapsulation of the drug. Dissolution characteristics of the encapsulated paraffin suspensions of nitrofurantoin, the directly encapsulated drug and nitrofurantoin powder were compared in buffer solutions of pH 1.12 and 7.2. The most rapid dissolution was shown by the nitrofurantoin powder followed by the directly encapsulated drug, the emulsified paraffin oil suspension of nitrofurantoin.
The drug was released from oil-containing microcapsules in successive stages representing initial release from capsular layer followed by sustained release from the oily core material.
Formalization of the gelatin-acacia coacervates should be allowed for enough time in order to obtain enteric protection.
No correlation was found between the equilibrium solubility of the drug in the buffer and the corresponding release profile in the same buffer.
The rate of release was slower as the viscosity of the core oil increased.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
109
121
https://bpsa.journals.ekb.eg/article_89534_82944b8f9db2ce4fc4bed6903b3db6b0.pdf
dx.doi.org/10.21608/bfsa.1984.89534
FORMULATION AND STABILITY OF HEPTAMINOL SUPPOSITORIES
A.
Kassem
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
author
M.
El-Miligi
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
author
S.
Ali
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
author
text
article
1984
eng
The chemical stability of Heptaminol Base and of Heptaminol Hydrochloride was determined after shelf-life storage in an aqueous solution at room temperature. Under these conditions, the Base was found about 10.54 times more stable than the hydrochloride. Heptaminol Base, therefore, was formulated in four different suppository bases. The prepared suppositories were subjected to the usual quality control tests, both when fresh and after shelf-storage for one year. The results of physical examination were so variable that a sharp conclusion to a preferred formula was not possible, However, studies of medicament dissolution revealed that quick and full-dose release of heptaminol was achieved from glycerogelatin based suppositories. On the other hand, suppositories based with polyethylene glycols have shown a prolonged heptaminol dissolution rates. The chemical stability of the medicament In the four different suppository bases was also investigated in absence and presence of several, stabilizers. The stability was found decreasing in the order of: Clycerogelatin, Cacao-Butter, Witepsol-E-75, and then Poly-ethylene Glycols. Butylated hydroxyanisole (BHA) was the best stabilizer in the two fatty-based formulae, while tocopherol succinate was the best stabilizer, while the mixture of sodium formaldehyde sulfoxylate (SFS) with sodium edetate was the worst.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
122
142
https://bpsa.journals.ekb.eg/article_89535_55fdf9a7230ff6d538b2b505fcaf788b.pdf
dx.doi.org/10.21608/bfsa.1984.89535
MACRO AND MICROMORPHOLOGY OF PANCRATIUM SICKENBERGI ASCH. ET SCHWEINF. EX BOISS GROWING IN BGYPT PART I: The Root, Bulb and Leaf
A.
Ali
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
M.
Mesbah
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
M.
Mohamed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1984
eng
The macro and micromorphology of roots, bulbs and leaves of Pancratium sickenbergi Asch. et Schweinf, ex Boiss growing in Egypt are presented with the view of determining the diagnostic features by which each organ can be identified in the entire and powdered form.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
143
158
https://bpsa.journals.ekb.eg/article_89539_5b0aab440abcb97d99309834d09c73f2.pdf
dx.doi.org/10.21608/bfsa.1984.89539
PHARMACOGNOSTICAL STUDY OF TECOMA CHRYSOTRICHA (MART. EX.) GROWING IN EGYPT
M.
Makboul
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
D.
Bishay
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1984
eng
Preliminary phytochemical screening of the shoots of Tecoma chrysotricha (Mart. ex.) Bignoniaceae, as well as macro and micromorphological characters of the stem and leaf of the plant were studied. The phytochemical screening proved the presence of sterols, triterpenes, flavonoids and traces of alkaloids.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
159
172
https://bpsa.journals.ekb.eg/article_89557_c3dc0f17fe97902ee132af3f95a43e24.pdf
dx.doi.org/10.21608/bfsa.1984.89557
ADSORPTION OF ISONIAZID ON INSOLUBLE TABLET EXCIPIENTS AND CHARCOAL
M.
Mesiha
Departments of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
S.
Shawky
Departments of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1984
eng
The adsorption of isoniazid onto the insoluble directly compressible tablet excipients : Emcotmpress, Avicel pH 101, Elcema P 50, P 100, G 250, ethyl cellulose and STA-Rx as well as talc, magnesium stearate and charcoal was studied. The adsorption followed the Langmuir equation over initial concentrations of 80-200 mmole/L of isoniazid solution in water or in buffer solutions of pH 2.1 and 7.2. The adsorption capacities were of the following sequence: charcoal > starch > celluloses and talc > ethyl cellulose > emcompress. No measurable adsorption was noted on magnesium stearate or glassware. The possible mechanisms of adsorption were discussed.
The kinetics of isoniazid release from compressed tablets using Emcompress, Avicel, ethyl cellulose and starch as the excipients did not correlate with the adsorption data, but the extent of release of drug had a good correlation with the adsorptive capacities of the excipients.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
173
189
https://bpsa.journals.ekb.eg/article_89562_089301a57707bf746761dc2938e09335.pdf
dx.doi.org/10.21608/bfsa.1984.89562
PHARMACOGNOSTICAL STUDY OF TECOMA ARGENTEA BER. & SCHUM CULTIVATED IN EGYPT
M.
Makboul
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
A.
Abdel-Baky
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
D.
Bishay
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1984
eng
The macro and micromorphology of the stem and leaf of Tecoma argentea (Ber. & Schum) are presented to show the diagnostic characters of these organs by which they could be identified and differentiated in the entire and powdered forms. The lipid content is also studied using TLC techniques revealing the presence of b-sitosterol and a-amyrin.
From the methanolic extract of the leaves seven flavonoids were isolated. Their structures were established by physical, chemical and spectral methods, proved to be: luteolin, scutellarein, auercetin, 6-hydroxyluteolin-7-o-glucoside, chrysin-7-o-glucoside, scutellarein-7-o-rhamnoside and rutin.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
190
206
https://bpsa.journals.ekb.eg/article_89566_7a43941e3070e7995e68c135972cfb4b.pdf
dx.doi.org/10.21608/bfsa.1984.89566
PHARMACOGNOSTICAL STUDY OF KHAYA SENEGALENSIS A. JUSS GROWING IN EGYPT PART I: Botanical and Chemical Study of the Leaf.
M.
Mesbah
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
M.
Abd El-Hafiz
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
M.
El-Shanawany
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
1984
eng
A detailed macro and micromorphological study of the leaves of Khaya senegalensis A. Juss is given to facilitate their identification either in the entire or in the powdered form. Moreover, 5 compounds have been isolated and proved to be a-amyrin, b-amyrin, b-sitesterol, quercetin and rutin.
The fatty acids were converted to their methyl esters and analyzed by G.L.C. In addition, a chromatospectrophotometric method was adopted for quantitative estimation of these flavonoids.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
207
223
https://bpsa.journals.ekb.eg/article_89568_baf8e48438ad72cc7d38b35ead1f0062.pdf
dx.doi.org/10.21608/bfsa.1984.89568
SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW SALICYLIC ACID DERIVATIVES CONTAINING A QUINAZOLIN-4-ONE MOIETY
M.
Abd-Alla
Department of Chemistry, Facu1ty of Science, Assiut University, Assiut, Egypt
author
A.
Yanni
Department of Chemistry, Facu1ty of Science, Assiut University, Assiut, Egypt
author
Sh.
Ahmed
Department of Microbiology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
M.
Abdel-Raheam
Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
text
article
1984
eng
A new series of salicylic acid derivatives of the general formula (IV) was prepared through the interaction of substituted 2-aryl-3-(haloformylalkyl)-3,4-dihydroquinazolin-4-one (III) with salicylic acid, methyl salicylate and sodium salicylate. The biological activities of these compounds such as antibacteria1, analgesic and antipyretic were determined.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
7
v.
1
no.
1984
224
236
https://bpsa.journals.ekb.eg/article_89572_2461c45646411b9d6d736b3c0cdac8de.pdf
dx.doi.org/10.21608/bfsa.1984.89572