SOLUBILITY AND DISSOLUTION ENHANCEMENT OF KETOTIFEN BY SOLID DISPERSION TECHNIQUE
Fergany
Mohamed
Department of Pharmaceutics, Faculty of Pharmacy, Assuit University, Assiut 71526, Egypt
author
Dina
Mohamed
Department of Pharmaceutics, Faculty of Pharmacy, Assuit University, Assiut 71526, Egypt
author
Omnia
Mahmoud
Department of Pharmaceutics, Faculty of Pharmacy, Assuit University, Assiut 71526, Egypt
author
text
article
2015
eng
Ketotifen (KT) solid dispersions and physical mixtures were prepared with the objective of solubility and dissolution improvement using Hydroxypropyl-Beta-Cyclodextrin (HP-β-CD), Pluronic 127 (PF-127), Pluronic 68 (PF-68), Polyethylene glycol 6000 (PEG 6000),and Polyethylene glycol 4000 (PEG 4000). The saturation solubility and in-vitro dissolution studies showed remarkable improvement in solubility and drug dissolution of these new solid dispersions and physical mixtures over pure ketotifen. The XRD, DSC, IR and SEM studies indicated the transformation of crystalline ketotifen (in pure drug) to amorphous ketotifen (in solid dispersions). This study concluded that the improved solubility as well as drug dissolution of these new ketotifen solid dispersions may be attributed to improved wettability and reduction in drug crystallinity, which can be modulated by appropriate level of hydrophilic carriers.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
38
v.
1
no.
2015
1
18
https://bpsa.journals.ekb.eg/article_63168_1cdedff66a4c6e1c16e1ab024dbf095e.pdf
dx.doi.org/10.21608/bfsa.2015.63168
NIOSOMES AS AN ORAL DRUG DELIVERY SYSTEM CONTAINING TENOXICAM
Gamal
Shazly
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Kingdom of Saudi Arabia
author
text
article
2015
eng
Niosomes vesicles are microscopic lamellar structures formed by mixing with nonionic surfactant, cholesterol and phosphate in aqueous media. Using niosomes as drug delivery system affords several significant advantages over conventional drug therapy. The main aim of this study was to formulate suitable niosome-encapsulated drug delivery for tenoxicam (antiinflammatory drug) and estimate the percentage encapsulation efficiency, in-vitro release and in-vivo anti-inflammatory effect. Different non-ionic surfactants, cholesterol and different charge inducing agents were used in different molar ratios. Three different methods were used for niosomes preparation. The higher entrapment efficiency was observed with niosomes prepared from span 40, cholesterol and stearylamine in 45:45:10 molar ratios (N11). The invitro release study was found that niosomes exhibiting higher entrapment efficiency showed slower release rate of drug than other formulae. The results of in-vivo study revealed that the niosomes significantly enhanced the anti-inflammatory effect of tenoxicam. The present work concluded that tenoxicam loaded niosomes was effective in sustaining the drug release resulting in diminished side effects and improved patient compliance.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
38
v.
1
no.
2015
19
29
https://bpsa.journals.ekb.eg/article_63170_daa71413d235e526da7ab5517981d6d2.pdf
dx.doi.org/10.21608/bfsa.2015.63170
SYNTHESIS OF SOME NOVEL 1,3,6-TRISUBSTITUTED-1HTHIAZOLO[3,2-f]PURINE-2,4-DIONES AND XANTHINE SCHIFF BASES AS POTENIAL ANTI-ASTHMATIC AND ANTIINFLAMMATORY AGENTS
Alaa
Hayallah
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
Reham
Shmeis
Department of Basic Pharmaceutical Sciences (Analytical Chemistry), Faculty of Pharmacy, Israa University, Amman, Jordan
author
Ahmad
Talhouni
Department of Applied Pharmaceutical Sciences (Pharmacology), Faculty of Pharmacy, Israa University, Amman, Jordan
author
text
article
2015
eng
In this study, the design, synthesis and preliminary pharmacological investigation of novel 1,3-diethyl-8-disubstituted xantines 12-18, 1,3,6-trisubstituted-1H-thiazolo[3,2-f]purine-2,4diones 19-25 and xanthine Schiff bases 28-33 was described. 1,3-Diethyl-8-substituted xantines 12-18 were prepared by the reaction of 1,3-diethyl-8-thioxo-3,7,8,9-tetrahydropurine-2,6-dione 4 with the appropriate phenacyl bromides 5-11. Compound 4 was in turn prepared by the reaction of 5,6-diamino-1,3-diethyluracil 3 with carbon disulfide. The derivatives 19-25 were obtained by cyclodehydration of compounds 12-18 in polyphosphoric acid (PPA). Schiff bases 28-33 were synthesized by the reaction of acetohydrazide 27 with appropriate aldehyde in refluxed ethanol. The effect of the new derivatives as potential anti-asthmatic was evaluated using acetycholine induced brocnhospasm in Guinea pigs, most of tested compounds showed significant anti-bronchoconstriction activity in comparison with aminophylline as a standard drug. Anti-inflammatory activity of the target compounds was investigated using indomethacin as a reference drug and some compounds exhibited potent anti-inflammatory activity.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
38
v.
1
no.
2015
31
46
https://bpsa.journals.ekb.eg/article_63174_1a06139d0993cdbcb11353bfa1c8b017.pdf
dx.doi.org/10.21608/bfsa.2015.63174
MUCOADHESIVE POLYMERS AS EFFICIENT DRUG DELIVERY SYSTEMS
Gamal
El-Gindy
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
Mona
El-Mahdy
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
Ghareb
Soliman
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
Abeer
Hassan
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
2015
eng
The drug action can be reinforced as a result of the development of new drug delivery systems. Over the past few decades, mucosal drug delivery has received a great deal of attention to improve both the local and systemic drug effects. Drug delivery across the mucosa bypasses the first-pass hepatic metabolism and avoids the degradation caused by the gastrointestinal enzymes. Mucoadhesive dosage forms are designed to enable prolonged retention at the desirable site of action, provide sustained release of drug and thus, lead to an improved bioavailability, as well as therapeutic outcomes. Compared with other mucosal tissues, vaginal mucosal cavity is more appropriate and attractive for drug delivery. In addition, a prolonged contact of mucoadhesive dosage forms with the vaginal mucosa may be achieved more easily than at other absorption sites like rectum or intestinal mucosa. This review aims to highlight the recent advances in the study of mucoadhesion and mucoadhesive polymers. It provides an overview of the structure of mucosal membranes, the mechanism and theories involved in mucoadhesion, and finally it describes briefly the main characteristics and the advantages of vaginal mucoadhesive drug delivery systems compared with other delivery systems.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
38
v.
1
no.
2015
47
60
https://bpsa.journals.ekb.eg/article_63175_0ab02e8f5909ed8f061c954d7f0f4dff.pdf
dx.doi.org/10.21608/bfsa.2015.63175
IN-VITRO AND IN-VIVO EVALUATION OF SUSTAINED-RELEASE SUPPOSITORIES CONTAINING THEOPHYLLINE MICROSPHERES
Gamal
Mahrous
Department of Pharmaceutics, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
author
Gamal
Shazly
Department of Pharmaceutics, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
author
Sayed
Auda
Department of Pharmaceutics, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
author
Hesham
Tawfeek
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University 71526, Assiut, Egypt
author
text
article
2015
eng
The sustained release microspheres of theophylline were formulated using non-solvent addition technique. The in-vitro dissolution of the drug from the fabricated microspheres that having size ranges of 300-600, 600-800 and 800-1000 µm was tested. The release of theophylline was extended over 8 hrs and it was found that the drug release decreased nonsignificantly as the particle size increased (p≥ 0.05). Incorporating theophylline-containing microspheres into suppository formulation using polyethylene glycol base resulted in a slight increase in dissolution rate, but still in a sustained release pattern over 8 hrs. In-vivo study of the prepared suppositories on beagle dogs revealed that the peak of theophylline serum concentration Cmax (mean±S.D) was 11.1+0.3 µg/mL. It was also found that AUC(0–24hrs) value averaged 154.7±20.3 µg-h/ml. The median peak time (Tmax) was 3.0 hrs and MRT was 13 hrs indicating a sustained effect.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
38
v.
1
no.
2015
91
98
https://bpsa.journals.ekb.eg/article_63177_e8dea063f5cc0a2f9ebc61c6c608ab0e.pdf
dx.doi.org/10.21608/bfsa.2015.63177
MACRO-AND MICROMORPHOLOGY OF THE LEAVES, STEM BARK AND FLOWERS OF PUNICA GRANATUM L. VAR. NANA CULTIVATED IN EGYPT
A.
El-Moghazy
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
A.
Khalifa
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
S.
Bayoumi
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
H.
Sayed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
text
article
2015
eng
Punica granatum L. var. nana (ornamental pomegranate) belongs to family Punicaceae. It is popularly planted in gardens for ornament. The root, stem bark and to a lesser extent fruit rind of the edible pomegranate had been commonly used as a vermifugal or taenicidal agent on tapeworms. By reviewing the literature, no botanical studies were done on Punica grantum L. var. nana, so this study aims for characterization and identification of this plant in both entire and powdered forms.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
38
v.
1
no.
2015
99
125
https://bpsa.journals.ekb.eg/article_63178_ab9653f99be1fd7a26d88e7893f21b1f.pdf
dx.doi.org/10.21608/bfsa.2015.63178
BOTANICAL STUDY AND DNA FINGERPRINT OF CEIBA PENTANDRA (L.) GAERTN. VAR. PENTANDRA CULTIVATED IN EGYPT
Faten
Darwish
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
author
Mohamed
Orabi
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut, Egypt
author
Mohamed
Abdelkader
Department of Pharmacognosy, Faculty of Pharmacy, Sohag University, Nasr City, Eastern Avenue, Sohag, Egypt
author
Mohamed
Abou-Elela
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut, Egypt
author
text
article
2015
eng
Ceiba pentandra (L.) Gaertn. (kapok) (F: Bombacaceae) is a large, fast growing tree of up to 50 m height. It grows naturally in the tropical and subtropical regions of the world and planted as a shade tree. In traditional medicine, it is mainly used as an emetic, diuretic and antispasmodic agent. Extracts of different morphological parts of the plant has been also recommended for the treatment of various ailments, include diabetes, bronchitis, skin diseases, diarrhea, dysentery, eye diseases, arthritis, insect bite and chronic fever. There are at least four common varieties of Ceiba pentandra species include; var. caribaea (DC.) Bakh., var. guineensis (Schumach. & Thonn.) H. G. Baker, var. pentandra and var. indica Bakhuisen. However, there were no specific identification standards for such varieties in the previous researches. In this study, a detailed description for the morphological and anatomical characters of the leaves, stems and fruits of Ceiba pentandra var. pentandra is performed. Additionally, the DNA fingerprint of the variety pentandra was established to help in its future identification at the genomic level.
Bulletin of Pharmaceutical Sciences Assiut University
Assiut University, Faculty of Pharmacy
1110-0052
38
v.
1
no.
2015
61
90
https://bpsa.journals.ekb.eg/article_63180_0c7909004dc7579660baa69d03b226da.pdf
dx.doi.org/10.21608/bfsa.2015.63180