ethylcellulose 20 > Aerosil R972 > Aerosil 200. The dependence of release rate (K) on hardness (H) may be approximated by the equation, Ln K = a H + b. The release mechanism follows zero order kinetic.
The antiinflammatory activity of the coevaporates was studied in albino rats using trypan-blue method. The coevaporates were also tested in albino mice for their analgesic activity using hot plate and p-benzoquinone induced writhing methods. The obtained results revealed that Eudragit RSPM and Aerosil 200 were the most effective in sustaining the antiinflammatory and analgesic actions of ibuprofen, while ethylcellulose 20 was the least effective. Histological examination of rat's stomach proved the efficiency of the tested coevaporates in inhibiting the ulcerogenic effects caused by the plain drug.]]>
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