Phytochemical study of the contents of the different organs of C. didumobotrya Fres. Resulted in the isolation and characterization of chrusophanol, physcion, aloe-emodin, 2- methoxystypandron, fallacinol, and uracil. Physcion, emodin, fallacinl and uracil were isolated for the first time from this plant. The identification was based on physical, chemical and spectral studies including UV, IR, 1H, 13C-NMR and MS analysis. The 13C-NMR assignments of aloe-emodin are reported here for the first time.