@article { author = {Sakr, F. and Abd El-Gawad, A. and Zin El-Din, E.}, title = {FORMULATION AND EVALUATION OF BEADS AND MOLDED PREPARATIONS CONTAINING GRISEOFULVIN}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {11}, number = {1}, pages = {1-17}, year = {1988}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1988.73265}, abstract = {Solid dispersion containing polyethylene glycols (PEG) and different ratios of griseofulvin were made into beads and molded tablets. Beads were prepared by a newly designed technique referred to as the "dry solidification technique" (DST). This was based on dropping the molten drug-polymer mixtures from a syringe needle onto top of talc powder beds chosen as solidification substances. Molded tablets were obtained by pouring the molten mixture into a tablet triturate mold placed on aluminium foil sheets. The formed beads and tablets were examined for their physicomechanical properties and physiological availabilities. Increasing drug contents and PEG mol. Wts. were found to increase beads and tablets hardness while decreased their dissolution rates and resistance to abrasions. The mechanical properties and dissolution rates of the molded tablets were also compared with those of hardly compressed tablets containing ranges of particle size between 125-150 mm (A) and 212-250 mm (B) of corresponding solid dispersions. Molded tablets were found to be mechanically stronger than those of (A) and (B) respectively, however their dissolution rates remained almost the same. Bioavailability results of the different preparations were found to be parallel with those of their dissolution rates; so that maximum urinary excretion of the drug and higher physiological availability were observed in case of beads rather than those of molded or compressed tablets. }, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_73265.html}, eprint = {https://bpsa.journals.ekb.eg/article_73265_6b8dfda5d1040da0502df8fd5bf52085.pdf} } @article { author = {El-Kommos, Michael and Emara, Kamla}, title = {SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN PHARMACEUTICAL SECONDARY AROMATIC AMINES USING 3-METHYLBENZOTHIAZOLIN-2-ONE HYDRAZONE}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {11}, number = {1}, pages = {18-28}, year = {1988}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1988.73266}, abstract = {Out of 7 pharmaceutical secondary aromatic amines tested, the oxidative coupling reaction of 3-methyl-benzothiazolin-2-one hydrazone with aromatic amines in the presence of iron (III) ammonium sulphate was applied to the determination of folic acid, primaquine phosphate and lucanthone hydrochloride. The wavelengths of maximum absorption were 530 nm (for primaquine phosphate), 580 nm (for lucanthone hydrochloride) and 660 nm (for folic acid) with molar absorptivities of 4.6 x 104, 2.3 x104 and 5.0 x 104 respectively. Beer's law was obeyed in the concentration range of 2-10 mg ml-1 (for primaquine phosphate), 2-16mg ml-1 (for lucanthone hydrochloride) and 1-10mg ml-1 (for folic acid). The proposed method was applied for the quantitative of folic acid, primaquine phosphate and licanthone hydrochloride in pure form as well as in tablets. Results of analyses were compared with the B.P. and U.S.P. procedures.   }, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_73266.html}, eprint = {https://bpsa.journals.ekb.eg/article_73266_effb141ea223a9fd33f3b92b2dc28a58.pdf} } @article { author = {Shawky, S. and El-Faham, T.}, title = {INTERACTIONS OF RIBOFLAVINE WITH CERTAIN ANALGESICS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {11}, number = {1}, pages = {29-49}, year = {1988}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1988.73267}, abstract = {The interaction of riboflavine with certain analgesics viz, paracetamol, phenazine, aspirin and acetanilide was investigated. The solubility of riboflavine was increased linearly with increasing the concentration of both paracetamol and phenazone. Aspirin and acetanilide however showed no effect on the solubility of riboflavine. The apparent partition coefficient of riboflavine between chloroform and water was decreased to variable extents in the presence of different molar ratios of riboflavine and of the tested analgesics. The diffusion rate f riboflavine through cellophane membrane was enhanced in presence of paracetamol followed in decreasing order by aspirin and phenazone. However, acetanilide, showed no increasing effect on the diffusion rate of riboflavine. The presence of these analgesics showed marked changes in the UV and IR absorption spectra of riboflavine. The Job's method of continuous variation was adopted to investigate these interactions and complexes of 1:1 molar ratio were revealed between riboflavine and each of paracetamol, aspirin and phenazone. It could be concluded that complexation between riboflavine (a very slightly soluble drug in water) and the commonly used analgesics viz., paracetamol, aspirin and phenazone led to changes in the solubility, partition and diffusion rate of the vitamin which in turn could affect its absorption and availability. }, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_73267.html}, eprint = {https://bpsa.journals.ekb.eg/article_73267_814f0be059b412de6bbc6b0d4834e89b.pdf} } @article { author = {Mulley, B. and Aboutaleb, A. and Abdel Rahman, Aly and Ahmed, S.}, title = {INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES: IV- PHASE DIAGRAM OF TEMAZEPAM-POLYETHYLENE GLYCOL BINARY SYSTEMS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {11}, number = {1}, pages = {50-69}, year = {1988}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1988.73268}, abstract = {Differential scanning calorimetery and hot stage microscopy were used to build up temperature-composition phase diagrams for temazepam-polyethylene glycol 2000, 4000 and 6000 physical mixtures and comprecipitates. The phase diagram showed the systems to be of the monotectic type, with the monotectic species being the pure drug. Phase diagram of the drug and the investigated polyethylene glycols helped in ruling out the possibility of forming solid solution or molecular compound within the concentration range of the components investigated. Differential scanning calorimetery was also utilized for predicting the melting behaviour of temazepam and polyethylene glycols separately and as coprecipitates and physical mixture binary systems. A good correlation was found between the position of the system on the phase diagram and its dissolution rate. The highest the carrier content, the nearest the system would be to the monotectic composition, the highest the release rate of the drug. }, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_73268.html}, eprint = {https://bpsa.journals.ekb.eg/article_73268_d25ca0c3e630a5f46ac59ab628b35b1c.pdf} } @article { author = {Mulley, B. and Aboutaleb, A. and Abdel Rahman, Aly and Ahmed, S.}, title = {INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES: V- THERMODYNAMICS OF TEMAZEPAM SOLUBILIZATION}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {11}, number = {1}, pages = {70-87}, year = {1988}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1988.73269}, abstract = {Temazepam was solubilized by series of non-ionic surfactant solutions including polysorbates, Eumulgins, Brjs, Myrjs and cetomacrogol as well as ionic ones including sodium lauryl sulphate and cetrimide at different temperatures. Among the non-ionic surfactant solutions investigated, polysorbate 80 was found to be the most efficient solubilizer at different temperatures investigated, while Myrj 59 was the least. For the ionic ones, sodium lauryl sulphate proved to be more efficient than cetrimide. Thermodynamic parameters for the solubilization of temazepam in polysorbates and Eumulgins were calculated in order to investigate the thermal process of micellar solubilization. These parameters include the heat of solution, DH, the free energy change for the transfer of temazepam from aqueous phase to micellar phase. DG and the entropy of solubilization, DS. For all systems DG was a negative value indicating spontaneous solubilization. The positive values of entropy, DS, suggest a decrease in the degree of ordering when temazepam dissolved in the micellar phase. This positive values of entropy also implies that temazepam molecules into micelle interior.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_73269.html}, eprint = {https://bpsa.journals.ekb.eg/article_73269_8e27ff260b2cffbb532b1ed394f302ea.pdf} } @article { author = {Bishay, D. and El-Sayyad, S. and Abd El-Hafiz, M. and Achenbach, H. and Desoky, E.}, title = {PHYTOCHEMICAL STUDY OF MURRAYA EXOTICA L. CULTIVATED IN EGYPT II- COUMARINS OF THE LEAVES}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {11}, number = {1}, pages = {88-104}, year = {1988}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1988.73476}, abstract = {Five coumarins were isolated from the methylene chloride fraction of the methanol extract of the leaves of Murraya exotica L. cultivated in Egypt and identified as; (±) erythromurranagatin, (-) minumicrolin, Murralogin, 7-methoxy-8(2`-hydroxy-3-ethxy-3-methyl-butyl) coumarin and murraxocin. The identification and structure determination are based on physical, chemical and spectral studies including UV, IR, 1HNMR, 13CNMR and MS analyses. Three of them were shown to be either enantiomer to known derivatives or new. The other two coumarins were identified as murralongin and murraxocin. The antimicrobial and cytotoxic activities of the isolated compounds were studied.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_73476.html}, eprint = {https://bpsa.journals.ekb.eg/article_73476_680216d35cb197fc92656ae40b0687fa.pdf} } @article { author = {Bishay, D. and El-Sayyad, S. and Abdel-Hafiz, M. and Achenbach, H. and Desoky, E.}, title = {PHYTOCHEMICAL STUDY OF MURRAYA EXOTICA L. CULTIVATED IN EGYPT III- COUMARINS AND CYCLOARTENOLS OF THE LEAVES}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {11}, number = {1}, pages = {105-121}, year = {1988}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1988.73481}, abstract = {Two coumarins (osthol and aurapten), two cycloartenols (lupeol and 3-epi-cycloartenol), beside cis-nerolidol were isolated from cyclohexane fraction of the methanolic extract of the leaves of Murraya exotica L. For the first time, we report the presence of aurapten in the plant, cis-nerolidol and lupeol in the species, and 3-epi-cyclolaudenol in the family. The antimicrobial and cytotoxic activities of the isolated compounds were studied.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_73481.html}, eprint = {https://bpsa.journals.ekb.eg/article_73481_aad1c865d1b5d63ce05863027ecd0a04.pdf} } @article { author = {El-Sayyad, S. and Abdel-Baky, A. and El-Shanawany, M. and El-Ghondakly, Kh.}, title = {MACRO- AND MICROMORPHOLOGY OF CASSIA SPECTABILIS DC. PART 1: THE STEM AND LEAF}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {11}, number = {1}, pages = {122-140}, year = {1988}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1988.73484}, abstract = {The macro- and micromorphology of the stem and leaf of Cassia spectabilis DC., cultivated in Egypt have been investigated in order to determine the diagnostic features by which each organ could be identified both in the entire and powdered forms.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_73484.html}, eprint = {https://bpsa.journals.ekb.eg/article_73484_ab475f8ecda05c07c4ea881d169b0c18.pdf} } @article { author = {El-Kommos, Michael and Emara, Kamla}, title = {SPECTROPHOTOMETRIC ASSAY OF CERTAIN BENZODIAZEPINE DRUGS THROUGH COMPLEX FORMATION REACTION}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {11}, number = {1}, pages = {141-153}, year = {1988}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1988.73485}, abstract = {A simple and accurate spectrophotometric method was developed for the determination of diazepam, prazepam and flunitrazepam. The method is based on the interaction of the benzodiazepine drug containing an active methylene group with 1,3-dinitrobenzene in presence of tetraethylammonium hydroxide to form a violet coloured d-complex (lmax=560 nm). Beer's law is obeyed over the concentration ranges 2-20 mg ml-1 (for diazepam), 5-30 mg ml-1 (for prazepam) and 5-40 mg ml-1 (for flunitrazepam). The method was successfully applied to the assay of the cited drugs in pure form and in pharmaceutical formulations. Results obtained agree well with those of official methods.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_73485.html}, eprint = {https://bpsa.journals.ekb.eg/article_73485_648017e674e087e41165e5561fde7381.pdf} } @article { author = {El-Emary, N. and Attia, A.}, title = {LIGNANS AND SESQUITERPENE LACTONES FROM THE ROOT BARK OF ARTEMISIA ARGENTEA}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {11}, number = {1}, pages = {154-161}, year = {1988}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1988.73495}, abstract = {The root bark of Artemisia argentea L'Her (Asteraceae) contain beside the known sesquiterpene lactones, arborescin [1], argentiolide B [3], deacetyl argentiolide B[2] and artemolin [4] previously isolated from the aerial parts of the same plant, a group of lignan compounds namely (+)-sesamin [5], aschantin [6] and demethoxy excelsin [7] isolated from the plant for the first time. All the known compounds were identified by spectroscopic analysis and comparison with authentic reference materials isolated from the aerial parts or by comparison with data cited in the literature.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_73495.html}, eprint = {https://bpsa.journals.ekb.eg/article_73495_f3a5537cc8588415b12e2aa0dd5c9bd7.pdf} }