@article { author = {Ali, A. and El-Sayyad, S. and Desouky, E.}, title = {A CONTRIBUTION TO THE CHEMISTRY OF STERCULIA DIVERSIFOLIA DONN CULTIVATED IN EGYPT}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {244-255}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102083}, abstract = {From Sterculia diversifolia Donn, luteolin, quercetin, kaempferol, quercetin-3- arabinoside and P-Coumaric and isochlorogenic acide were isolated from the leaves. While, caffeine, theobromine, theophylline and choline were isolated from the defatted seeds. Lipids of all the organs showed the presence of a hydrocarbon m.p. 58°C, a-amyrin and b-Sitosterol in the unsaponifiable fraction. Fatty acids were found to be oleic, myristis, palmitic and stearic.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102083.html}, eprint = {https://bpsa.journals.ekb.eg/article_102083_39c185ad11b4166e0f49a87064e1601c.pdf} } @article { author = {Nouh, A.}, title = {EFFECT OF BINDER AND ITS CONCENTRATION ON THE PHYSICAL CHARACTERISTICS OF SULFADIAZINE GRANULES AND TABLETS PREPARED BY WET AND FLUIDIZED-BED GRANULATION METHODS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {256-270}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102084}, abstract = {Sulfadiazine was granulated by the fluidized-bed (Uni-Glatt), as well as by the conventional massing and screening (Wet granulation) methods. The effects of binder concentration and its type on the mechanical properties of granules and their corresponding tablets, as well as on disintegration time and drug content were studied. It was found that the fluidized bed method was an efficient with all tested binders to produce superior granules. However, disintegration time of the corresponding tablets was found to be increased markedly and was greatly affected by the type and the concentration of the binder. Some suggestions to overcome this problem are stated.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102084.html}, eprint = {https://bpsa.journals.ekb.eg/article_102084_134926f1e0343421e7627e17dc045cae.pdf} } @article { author = {Ali, A. and El-Emary, N. and El-Toweesy, O.}, title = {MACRO AND MICROMORPHOLOGY OF THE LEAF, STEM AND FLOWER-HEADS OF TAGETES ERECTA L.}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {271-294}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102088}, abstract = {The macro and micromorphology of the leaves, stems and flower-heads of Tagetes erecta L., is described and illustrated for the purpose of its identification in the entire and powdered form.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102088.html}, eprint = {https://bpsa.journals.ekb.eg/article_102088_ba534234845804a1411bf43e078fea7b.pdf} } @article { author = {El-Sabbagh, H. and El-Shaboury, M. and Nouh, A. and Abd El-Gawad, A.}, title = {EFFECT OF SURFACTANTS TREATED BINDER ON THE PHYSICAL PROPERTIES AND BIOAVAILABILITY OF SULFADIAZINE TABLETS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {295-309}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102090}, abstract = {The effect of untreated gelatin binder along with surfactant treated gelatin on the physical properties of sulfadiazine tablets were studied. Surfactant treated gelatin was found to lower the d.t., and hardness, but increased friability value. Further, the effect of surfactant treated gelatin incorporated in sulfadiazine tablets, on the dissolution rate was studied and was found to be better than untreated ones. Concentration of 2.5% of surfactant proved to be the most convenient in producing tablets with good physical properties and high dissolution rate. The maximum urinary excretion of sulfadiazine and higher physiological bioavailability were observed in case of tablets prepared with surfactant treated gelatin.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102090.html}, eprint = {https://bpsa.journals.ekb.eg/article_102090_0f21db46c423aaa6f0bd44c4328bc3df.pdf} } @article { author = {Aboutaleb, A. and Ahmed, S.}, title = {SOLUBILIZATION OF CARBAMAZEPINE USING COSOLVENTS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {310-320}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102091}, abstract = {Solubilization of Carbamazepine was achieved through cosolvency using binary or ternary solvent systems at 25°. It was found that the aqueous solubility of the medicament was increased. However, the extent of the solubility promoting effect was dependent on the type and the concentration of the cosolvent used.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102091.html}, eprint = {https://bpsa.journals.ekb.eg/article_102091_14671622f15cf90bbffe2f3dfd14a6e2.pdf} } @article { author = {Aboutaleb, A. and Ahmed, S.}, title = {EFFECT OF PH, TEMPERATURE AND CERTAIN ADDITIVES ON THE SOLUBILIZATION OF CARBAMAZEPINE BY SELECTED NON-IONIC SURFACTANT SOLUTIONS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {321-334}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102092}, abstract = {The effect of incorporation of various organic additives on the solvent power of the different micelles for Carbamazepine was investigated. The variation in the pH value as well as the temperature of these solution on the degree of solubilization of Carbamazepine was also studied. It was found that propylene glycol increased the solvent power of the different micelles, while glycerol, and PEG 1000, 4000 and 6000 decrease their solubilizing capacity. Raising the temperature and lowering of pH value also increased the solvent power of the micelles.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102092.html}, eprint = {https://bpsa.journals.ekb.eg/article_102092_1315747613c95bfed3bfbffd1d508310.pdf} } @article { author = {Aboutaleb, A. and Ahmed, S.}, title = {A STUDY ON CERTAIN SOLUBILIZED SYSTEMS CONTAINING CARBAMAZEPINE}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {335-350}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102093}, abstract = {Solubility and ultrafiltration techniques were used for studying solubilized systems containing carbamazepine. The effect of variations in the alkyl, as well as ethylene oxide chain lengths of the surfactant molecules on the degree of solubilization of this solute was investigated. The results obtained from the solubility measurements agreed well with those obtained from ultrafiltration experiments which gave further support to the partition model of solubilization.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102093.html}, eprint = {https://bpsa.journals.ekb.eg/article_102093_12e91c2776dcda9e84b2920fc308576d.pdf} } @article { author = {Kassem, A. and Kassem, M. and Ibrahim, E. and Nouh, A.}, title = {EFFECT OF SOME ADDITIVES ON THE ANTIMICROBIAL ACTIVITY OF KANAMYCIN AND GENTAMICIN IN OINTMENTS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {351-360}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102094}, abstract = {Kanamycin and gentamicin ointments were prepared using four different ointment bases, namely oleaginous, absorption, emulsion and water-soluble bases. Glyaerol, Propylene glyaol, polyethylene glycols 200, 400, 600 and 1000, water, alcohol, dimethylformamide, dimethylsulfoxide and polysorbate 80 were separately incorporated at 10% concentration into all the ointments prepared. The effect of all these additives on the antimicrobial activity of gentamicin and kanamycin was investigated. Water-soluble base was found to be the best for preparing kanamycin and gentamicin ointments. Of the additives tested, glycerol, dimethylformamide dimethylsulfoxide and polysorbate 80 proved to have more effect in increasing the activity of kanamycin than the other additives. while for gentamicin, the best effect was with either glycerol, propylene glycol or polyethylene glycol in water soluble base, and with 10% water in oleaginous base.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102094.html}, eprint = {https://bpsa.journals.ekb.eg/article_102094_8a580aeedfd7e0c8004ab2560daa21ca.pdf} } @article { author = {Kassem, M. and Elmahrouk, G. and Kassem, Alaa}, title = {SOLUBILIZATION OF MEFENAMIC ACID BY NON-IONIC SURFACTANTS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {361-372}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102095}, abstract = {Mefenamic acid was solubilized by series of non-ionic surfactant solutions. It was found that the solubilizing capacity of the surfactant solution increased linearly by increasing the surfactant concentrations above their CMC's. The solvent power of the different micelles was affected by change in surfactant structure.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102095.html}, eprint = {https://bpsa.journals.ekb.eg/article_102095_14035c4517373487f82110cfb5de2cd8.pdf} } @article { author = {Aboutaleb, A. and Ahmed, S.}, title = {SOLUBILIZATION OF CARBAMAZEPINE USING HYDROTROPIC AGENTS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {373-386}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102096}, abstract = {The effect of number of hydrotropic agents be longing to diverse chemical groups, e.g. sugars, sugar alcohols, amides, imides, acids and salts, on the water-solubility of the practically insoluble antiepileptic drug Carbamazepine at 25° was studied. Also, comparison of the solubilizing efficiency of the different hydrotropic agents was performed. It is clearly evident that the solubilizing efficiency of these hydrotropic agents depends upon both type and concentration of the tested additives used in this study.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102096.html}, eprint = {https://bpsa.journals.ekb.eg/article_102096_d7cc09c0236345442b299b61dc9de345.pdf} } @article { author = {Kassem, M. and Nouh, A. and El-Bayomy, T. and Kassem, Alaa}, title = {FORMULATION AND IN-VITRO EVALUATION OF RIBOFLAVIN TABLETS PREPARED BY FLUIDIZED BED GRANULATION TECHNIQUE}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {387-398}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102097}, abstract = {Spray granulation technique using fluidized bed was used for preparing riboflavin granules. Five binders were used for granulation as spray liquids, Polyvinylpyrrolidone proved to be the most suitable binder followed by sodium alginate and sodium carboxy methyl cellulose. Methyl cellulose produced tablets which disintegrated within the U.S.P.XX. Limit, but of low dissolution rate; while ethyl cellulose gave tablets which did not conform to the official Limit, but the drug was released from the tablet matrix faster than from tablets prepared by methyl cellulose.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102097.html}, eprint = {https://bpsa.journals.ekb.eg/article_102097_03abe6f78ce52688896cca3a23a08d4a.pdf} } @article { author = {Abdel-Baky, A. and Ross, S. and Makboul, M. and Bishay, D.}, title = {PHARMACOGNOSTICAL STUDY OF AVICENNIA OFFICINALIS L. GROWING IN EGYPT PART I: MACRO AND MICROMOROPHOLOGY OF THE STEMS AND LEAVES}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {399-415}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102098}, abstract = {The Macro and micromorophological characters of the stem and leaf of Avicennia officinalis L. growing in Egypt are presented to show the diagnostic characters of these orange by which they could be identified and differentiated in the entire and powdered forms.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102098.html}, eprint = {https://bpsa.journals.ekb.eg/article_102098_9da54e389b95f7bde895789155cf78b8.pdf} } @article { author = {Ali, A. and Mesbah, M. and Sayed, H.}, title = {PHARMACOGNOSTICAL STUDY OF GYNANDROPSIS PENTAPHYLLA (HURHUR) GROWING IN EGYPT PART I: MACRO AND MICROMORPHOLOGY OF THE ROOT, STEM AND LEAF}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {416-433}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102099}, abstract = {The macro and micromorphology of the root, stem and leaf of Gynandropsis pentaphylla Hurhur growing in Egypt are presented with view of finding the diagnostic characters for their identification in the entire and powdered forms.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102099.html}, eprint = {https://bpsa.journals.ekb.eg/article_102099_95f48ceca7e54875f2bfba219f9577c3.pdf} } @article { author = {Ali, A. and Sayed, H. and Mesbah, M.}, title = {PHARMACOGNOSTICAL STUDY OF GYNANDROPSIS PENTAPHYLLA (HURHUR) GROWING IN EGYPT PART II: MACRO AND MICROMORPHOLOGY OF THE FLOWER AND FRUIT}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {434-449}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102100}, abstract = {A detailed study of the macro and micromorphology of the flower and fruit of Gynandropsis pentaphylla Hurhur growing in Egypt are presented to help in their identification both in the entire and powdered forms.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102100.html}, eprint = {https://bpsa.journals.ekb.eg/article_102100_47886d2228f214e21d5edd911c3f0c75.pdf} } @article { author = {El-Bitar, H.}, title = {CNS DEPRESSANT, ANALGESIC AND ANTIINFLAMMATORY ACTIVITY OF CERTAIN OXANILAMIDE DERIVATIVES}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {6}, number = {2}, pages = {450-461}, year = {1983}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1983.102101}, abstract = {The present study was designed to evaluate the CNS depressant, analgesic and antiinflammatory activity of six N- {D-threo(-)-1-(p-nitrophenyl)-1,3-dihydroxyisopropyl}-N-4-substituted carbamyol-3-hydroxyoxanilamides. The CNS depressant activity of these compounds was evaluated by measuring their effects on the spontaneous motor activity of mice using the actophotometer technique, while the analgesic activity was evaluated by means of the writhing method. The antiinflammatory response was measured in rats by the trypan blue method. Aspirin was used in these experiments as a reference drug for comparative purposes.  This study revealed that the compounds in question possess certain degree of CNS depressant and analgesic activity comparable but less than that of aspirin. Variable degrees of antiinflammatory activity were observed and the effectiveness of some of these compounds was almost comparable to that of aspirin. The possible correlation between the chemical structure and pharmacological activity was proposed.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_102101.html}, eprint = {https://bpsa.journals.ekb.eg/article_102101_938b79cda9c7deeb573bd95da3c7020c.pdf} }