@article { author = {Ibrahim, S. and Kassem, A. and Attia, I. and Mohamed, S.}, title = {STUDIES ON THE SOLUBILITY OF RIFAMPICIN. I. EFFECT OF CO-SOLVENTS AND NONIONIC SURFACTANTS ON THE SOLUBILITY OF RIFAMPICIN}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {2}, number = {1}, pages = {1-10}, year = {1979}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1979.104844}, abstract = {The effect of a number of water-miscible co-solvents namely; glycerin, glycerin formal, propylene glycol, polyethylene glycol; 200, 300, and 400 polypropylene 420, dimethylformamide and dimethyl sulfoxid in various concentrations up to 50% with water, as well a number of nonionic surfactants namely; tween 20, tween 40, tween 60 and tween 80 in various concentrations up to 10% in water, on the equilibrium solubility of rifampicin was evaluated. It was found that the solubility of rifampicin is promoted to a marked extent in presence of the co-solvents and the nonionic surfactants. However, the extent of the solubility-promoting effect was dependent on the type and concentration of the co-solvent and the surfactant used. Presence of 50% co-solvents with water increased the solubility of rifampicin to 1.15, 1.2, 1.5, 6, 9, 14, 14.6, 60 and 121.3 times its original water-solubility in cases of; propylene glycol, glycerin-formal, glycerin, polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, dimethyl sulfoxide, polypropylene glycol 420 and dimethylformamide respectively. A 10% surfactant concentration in water, increased the solubility of rifampicin to 9.6, 8.52, 7.74 and 7.35 times its original water solubility in cases of tween20, tween 40, tween 80 and tween 60 respectively.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_104844.html}, eprint = {https://bpsa.journals.ekb.eg/article_104844_19205c1a527aaf04962c63d6c2d1db91.pdf} } @article { author = {Ibrahim, S. and Kassem, A. and Attia, I. and Mohamed, S.}, title = {STUDIES ON SOME FACTORS AFFECTING THE STABILITY OF RIFAMPICIN IN SOLUTION}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {2}, number = {1}, pages = {11-25}, year = {1979}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1979.104845}, abstract = {Rifampicin stability in relation to a number of factors namely; solvent type, pH value, type of buffering system, ionic strength and storage temperature was investigated. Kinetic treatment of the obtained data revealed first order pattern for rifampicin degradation. The degradation rate constant varied according to the type of the solvent, the pH of the solution, the type of the buffering components, the ionic strength and the storage temperature. Degradation was accelerated in solvents of higher dielectric constants in contrast to those of lower dielectric constants. The pH for minimal degradation was found to be pH 6.  Rifampicin degradation proceeded at minimal rate in presence of ascorbate buffer compared to formate, acetate, phosphate, Sorensens phosphate and Mcilvaine's citric acid-phosphate buffering systems. The calculated activation energy (Ea) and frequency factors of rifampicin was 15.47 K. cal/mol and 2.16 x 109 day-1 respectively.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_104845.html}, eprint = {https://bpsa.journals.ekb.eg/article_104845_9f46c3bd9c77367faffdef47cab90181.pdf} } @article { author = {Aboutaleb, A. and Sakr, A. and Abdelzaher, A.}, title = {DETERMINATION OF THE CMC OF SELECTED SURFACTANT SOLUTIONS IN SYSTEMS CONTAINING CHLORAMPHENICOL}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {2}, number = {1}, pages = {27-39}, year = {1979}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1979.104847}, abstract = {The solubility of Chloramphenicol was determined in solutions containing the following non-ionic surfactants: Tween 20, Tween 40, Tween  60, Emulgin C 1000, Emulgin C1500, Myrj 52, Myrj 53 and Myrj 59 together with cetrimide and sodium lauryl sulphate as representative examples for cationic and anionic surfactants. The solubilizing capacity of the different surfactant solutions above and below their CMC values were determined. It was concluded that all these surfactants when present in concentrations less than their CMC failed to enhance the solubility of chloramphenicol. The cationic and anionic surfactants showed the most significant increase in the drug solubility than the non-ionic surfactants above their CMC. The CMC values reported for the different classes of surfactants were found to be slightly different from literature reports.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_104847.html}, eprint = {https://bpsa.journals.ekb.eg/article_104847_c56a2827d3b0c4debe6e1d4a6583cf9d.pdf} } @article { author = {El-Sabbagh, H. and Aboutaleh, A. and Sakr, A. and Abdel-Hake, M.}, title = {A STUDY ON THE SOLUBILITY AND STABILITY OF ETHINYL OESTRADIOL}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {2}, number = {1}, pages = {41-58}, year = {1979}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1979.104849}, abstract = {Atrial was made to prepare solutions of ethinyl oestradiol by series of selected surfactants. It was found that the cationic surfactant was the best solubilizer for this hormone followed by the anionic then the non-ionic ones. The solubilized systems were further investigated for their stability under different storage conditions. It was noticed that the solutions prepared by non-ionic surfactants gave rise to the most stable preparation for this hormone, especially in the presence of antioxidants and preservatives. Storage of this preparation in amber coloured ampoules at 5° was also desirable, as it can keep its potency for a period up to 6 months.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_104849.html}, eprint = {https://bpsa.journals.ekb.eg/article_104849_5f56ca8dc8bf3cddabacca0c389af98f.pdf} } @article { author = {Abdel-Kader, M. and Taha, Aly and Abdel-Fattah, S.}, title = {ASSAY OF 3-SUBSTITUTED PYRIDINES THROUGH FUJIWARA REACTION}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {2}, number = {1}, pages = {59-68}, year = {1979}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1979.104851}, abstract = {3-Substituted pyridines of pharmaceutical interest with a carbonyl group in the 3-position have been determined by a modification of the Koenig's reaction without interferences from the 2-and 4-substituted isomers. Nicotinic acid, nicotinamide, and nikethamide in a strongly alkaline medium were reacted with chlorbutol in absolute ethanol on a steam bath for 5 minutes. The reaction mixture was cooled in ice bath and the pH was adjusted. The chromogen was developed by the use of a solution of thiobarbituric acid, barbituric acid or benzidine dihydrochloride where a stable color was formed showing a prominent absorption peaks at 535, 580, and 525 nm respectively. The relationship between absorbance and concentration is linear in the range of 0.005 - 0.05 mg per ml for nicotinic acid, and 0.01-0.1 g per ml for nicotinamide and nikethamide. The selectivity of the method within the 3-substituted members was also investigated.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_104851.html}, eprint = {https://bpsa.journals.ekb.eg/article_104851_33f1f9a6db54e4982a1c6f8b11ff9acb.pdf} } @article { author = {Taha, Aly and Abdel-Kader, M.}, title = {SELECTIVE CHROMATOGRAPHIC DETECTION OF TERTIARY N-ETHYL DRUGS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {2}, number = {1}, pages = {69-75}, year = {1979}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1979.104852}, abstract = {There are reagents available for the detection of basic drugs in general on paper and thin layer chromatograms. However, reagents selective for specific groups of basic drugs are few and usually differentiate compounds with grossly different structural features. There are no reagents available to differentiate tertiary, N-ethyl drugs from their N-methyl analogues. These compounds have common occurance among pharmaceuticals and are frequently prescribed in the same dosage form (e.g, cough, mixture containing N-ethyl antitussive with N-methyl antihistamine or an ephedrine analogue). N-methyl and N-ethyl compounds usually have close pKa values and similar solubility characteristics. This renders clear-cut separation in paper chromatography (PC) or thin layer chromatography (TLC) not always feasible. Thus identification of either type through Rf-values alone is not decisive.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_104852.html}, eprint = {https://bpsa.journals.ekb.eg/article_104852_dac27901a408b85ae3d5591a2d6b34c2.pdf} } @article { author = {El-Shabouri, Salwa}, title = {COLORIMETRIC DETERMINATION OF CERTAIN SYMPATHOMIMETIC DRUGS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {2}, number = {1}, pages = {77-89}, year = {1979}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1979.104853}, abstract = {A rapid, simple and highly sensitive spectrophotometric method for the determination of oxiderine tartrate, etilefrine hydrochloride, metaraminol bitartrate, orciprenaline sulphate and isoprenaline sulphate is described. The method depends on the reaction of aqueous solution of these drugs with the diazotized 5-chloro-2,4-dinitroaniline in alkaline medium to give a highly coloured product with characteristic lmax for each drug in the range of 420-550 nm. The colour produced in all cases obeys Beer's law. This method is suitable for the analysis of these drugs in pure forms and in pharmaceutical preparations without prior separation.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_104853.html}, eprint = {https://bpsa.journals.ekb.eg/article_104853_0a0f844305712e8241da5415b6c2a797.pdf} } @article { author = {El-Moghazy, A. and El-Emary, N.}, title = {A PRELIMINARY PHYTOCHEMICAL INVESTIGATION OF ARTEMISIA ARGENTEA L'HER GROWING IN EGYPT}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {2}, number = {1}, pages = {91-98}, year = {1979}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1979.104855}, abstract = {The phytochemical examination of Artemisia argentea L'Her. established the Pharmacopoeial constants and the percentage of extractives of the different organs. Such examination proved the presence of volatile oil, flavonoid aglycones and glycosides, sesquiterpene lactones, unsaturated sterols and or triterpenes, carbohydrates, besides traces of alkaloids or nitrogenous bases in the examined organs.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_104855.html}, eprint = {https://bpsa.journals.ekb.eg/article_104855_9aa57c68d63e1bc96d9f6b61f02a8843.pdf} } @article { author = {El-Sayyad, S. and Ross, S.}, title = {MACRO- AND MICROMORPHOLOGY OF THE STEM AND LEAVES OF LIMONIUM SINUATUM (L.) MILL. GROWN IN EGYPT}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {2}, number = {1}, pages = {99-116}, year = {1979}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1979.104856}, abstract = {The macro and micromorphology of the stem and leaves of Limonium sinuatum (L.) Mill. are presented with the aim of finding their characters by which they could be identified and differentiated.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_104856.html}, eprint = {https://bpsa.journals.ekb.eg/article_104856_7c522cce7cddf55d570e4cfd13d21376.pdf} } @article { author = {El-Moghazy, A. and Ross, S.}, title = {QUANTITATIVE DETERMINATION OF FLAVONOIDS PRESENT IN LIMONIUM SINUATUM MILL}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {2}, number = {1}, pages = {117-124}, year = {1979}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.1979.104858}, abstract = {A chromatospectrophotometric method was carried out for quantitative estimation of flavonoids in the flowers and leaves of Limonium sinuatum Mill and proved that flowers contain the highest percentage of flavonoids. The percentage of flavonoids (gm %) in flowers and leaves was as follows respectively: total aglycones (calculated as apigenin), (0.09, 0.24); apigenin, (0.048, 0.17); luteotin (0.034, 0.02); total glycosides (calculated as gossypin), (2.43, 0.44); gossypin (0.96, 0.14); 8-hydroxykaempferol-8-o-glucoside (1.01, 0.03).}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_104858.html}, eprint = {https://bpsa.journals.ekb.eg/article_104858_9c82240c3424dfa95c2065bdb5858919.pdf} }