@article { author = {S.T. Al-Jadabi, Kamal}, title = {PREPARATION, CHARACTERIZATION, THERMAL STUDIES, PHOTOCHEMICAL BEHAVIOURS AND ANTIMICROBIAL ACTIVITY OF COMPLEXES DERIVED FROM 5-METHYL-3-FURALDEHYDE THIOSEMICARBAZONE AND HG(II) SALTS OF HALLO ACIDS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {33}, number = {2}, pages = {95-105}, year = {2010}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.2010.147031}, abstract = {Complexes from of 5-methyl-3-furaldehydethiosemicarbazone (5M3HFTSC) and Hg(II) salts derived from inorganic (HCl) and organic hallo acids (CHCl2COOH or CF3COOH) have been prepared. There chemical structures were characterized using elemental analyses, conductivity spectral measurements, thermogravimetric methods and photochemical behaviours. The thermal studies of such complexes using thermogravimetric analysis (TGA), derivatives thermogravimetry (DrTG) from ambient temperature to 750°C showed three decomposition steps. These studies indicated that the thermal decompositions are not simples. The photolysis of the studied compounds has been carried out in the presence of H2O2. It was found that, the photolysis was enhanced in the presence of H2O2 due to the generation of .OH radicals which are very strong oxidizing agent. Biological activity of theses compounds was tested and screened for their in-vitro antibacterial and antifungal activity. The mixed ligand complexes generally are more active than the binary and free thiosemicarbazne ligand.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_147031.html}, eprint = {https://bpsa.journals.ekb.eg/article_147031_ad1d70ec745fc8f6f469f1018bad66b4.pdf} } @article { author = {El-Nuweihy, A. M. and El-Melegy, N. T. and Ameen, N. F. and Radwan, E. M.}, title = {ROLE OF ADIPONECTIN IN PATIENTS WITH NON-INSULIN DEPENDENT DIABETES MELLITUS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {33}, number = {2}, pages = {107-120}, year = {2010}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.2010.64723}, abstract = {Adiponectin is a collagen-like protein that is solely secreted by adipocytes. Differentstudies showed that it plays an important role in the pathophysiology of insulin resistance,diabetes and dyslipidemia and thus affects risk for cardiovascular disease and obesity. In thepresent study the role of adiponectin in pathogenesis of type 2 diabetes mellitus was evaluated.The current study was carried on 51 diabetic patients with documented NIDDM and 22 age andsex matched healthy controls. Diabetic patients were subdivided into 2 subgroups according toBMI where 40 were obese and 11 were non obese and according to the presence ofcardiovascular disease with obesity where 16 were obese with CVD and 24 were obese with noCVD. Controls were subdivided according to BMI where 7 were non obese and 15 were obese.The levels of plasma adiponectin, insulin, c-peptide, fasting blood glucose, glycatedhemoglobin, lipid profile, NO and lipid peroxides. The results of the present study showed thatadiponectin was significantly lower in all groups with variations compared to controls, in obesepatients with CVD than those without CVD. NO and MDA levels were higher in diabeticpatients than in controls and the highest levels of MDA were observed in patients withcardiovascular disease. Lipid profile was altered in diabetic patients showing higher levels thanin controls. In the diabetic patients, adiponectin was significantly positively correlated with NOand HDL, while it was significantly negatively correlated with glucose, HbA1C, Cholesterol,  LDL, insulin and c-peptide. The ability of adiponectin to increase insulin sensitivity inconjunction with its anti-inflammatory and anti-atherogenic properties have made this noveladipocytokine a promising therapeutic tool for the future.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_64723.html}, eprint = {https://bpsa.journals.ekb.eg/article_64723_82d9b5b3c7f562cb8423012d27f5d1e7.pdf} } @article { author = {M Rashwan, Nabila and A Mohamed, Abdel-Khalk and Saif El-Deen, Salwa and H Ahmed, Entsar and Abdalla Ismail, Shaymaa}, title = {PATTERN OF CANDIDA URINARY TRACT INFECTIONS AMONG CANCER PATIENTS IN SOUTH EGYPT CANCER INSTITUTE}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {33}, number = {2}, pages = {121-130}, year = {2010}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.2010.147033}, abstract = {The last decade has seen the sustained medical importance of opportunistic infections due to different Candida species mainly because of the worldwide increasing in the number of immunocompromised patients, who are highly susceptible to opportunistic infections. Urine samples were collected from 106 cancer patients in South Egypt Cancer Institute (SECI) that were cultured on Sabouraud dex­trose agar media for isolation of Candida species. After Gram staining subculture was done on Hicrome Candida Differential Agar media. Results of the previous media were compared with those obtained with API 20C AUX yeast identification kits. The study revealed an overall isolation rate of Candida species among urinary tract infections was 20.8% (22/106). Single type of Candida species was isolated from cancer patients with candiduria 16/22 (72.7%) while six Patients had mixed species. Candida albicans was the most frequent species isolated responsible for fungal urinary tract infections 27.3% (6/22). Non-Candida albicans species including Candida tropicalis (13.6%), Candida glabrata (13.6%), Candida stellatoides (9.1%), Candida krusei (4.5%) and Candida guilliermondii (4.5%) were also isolated. Candida albicans, Candida stellatoides and Candida guilliermondii could not be identified on chrom agar as all the isolates gave similar green colonies. Also Candida glabrata and Candida krusei could not be identified on chrom agar as they gave similar white colonies. Chrom agar identifies all Candida tropicalis as the isolates gave the typical pattern of purple to blue colonies. Candida albicans identified on Czapek Dox Agar media as they produced chlamydospores. The results of API 20C AUX were in 100% agreement with the results of Chrom agar in identification of Candida tropicalis. E- test on (SDA) was found to be an accurate method for antifungal susceptibility as it was compared with the reference broth microdilution method recommended by National Committee for Clinical Laboratory Standards (NCCLs). For fluconazole the E-test demonstrated 94.1% agreement for all candida species.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_147033.html}, eprint = {https://bpsa.journals.ekb.eg/article_147033_01f29dc788aed375ba67423c721e5d98.pdf} } @article { author = {Mahrous, Gamal}, title = {PRONIOSOMES AS A DRUG CARRIER FOR TRANSDERMAL DELIVERY OF MELOXICAM}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {33}, number = {2}, pages = {131-140}, year = {2010}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.2010.64728}, abstract = {The current investigation aims to evaluate the potential of proniosomes as a carrier fortransdermal delivery of a potent non-steroidal anti-inflammatory, meloxicam. Meloxicamloadedproniosomes were prepared and characterized for entrapment efficiency, surfacemorphology and in-vitro permeation across excised rat skin from various proniosome gelformulations using Franz diffusion cells. Various non-ionic surfactants were used to achieveoptimum encapsulation efficiency. Niosomes formed from using Spans and Tweens exhibitedhigh encapsulation efficiency. The prepared proniosomes significantly improved drugpermeation and reduced the lag time (p< 0.05). Proniosomes prepared with Span 60 provided ahigher meloxicam flux across the rat skin than did those prepared with Tween 80.Testing of the anti-inflammatory effect of meloxicam proniosomal gel showed betterpharmacological activity when compared with the standard meloxicam gel. The results suggestthat proniosomes can act as promising carriers offer an alternative approach for transdermaldelivery of meloxicam.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_64728.html}, eprint = {https://bpsa.journals.ekb.eg/article_64728_ab4e88220236ae502f37c5b9e5a5a54c.pdf} } @article { author = {A. Ali, A. and A. El-Shanawani, M. and A. Khalifa, A. and A. Mohammad, M.}, title = {MACRO- AND MICROMORPHOLOGY OF THE LEAVES, STEMS AND FLOWERS OF CHRYSANTHEMUM CARINATUM L.}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {33}, number = {2}, pages = {141-168}, year = {2010}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.2010.147034}, abstract = {The genus Chrysanthemum L. is sometimes called Ismelia, it comprises about 150 species native to tropical and temperate North and South America. Chrysanthemum carinatum L. is known as Painted daisy, German flag and Tricolor Chrysanthemum. Some species of genus Chrysanthemum are used medicinally to cure influenza symptoms, liver and menstrual disorders and have anti-inflammatory and antispasmodic effects.  }, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_147034.html}, eprint = {https://bpsa.journals.ekb.eg/article_147034_6343188b5df696ba82a2c11680502758.pdf} } @article { author = {Mohafez, Omar and Abdel-Raheem, Ihab and Nafady, Alaa}, title = {ANTIOXIDANT, LIPID PEROXIDATION-INHIBITORY AND ANTIULCER ACTIVITIES OF BROWN PROPOLIS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {33}, number = {2}, pages = {169-177}, year = {2010}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.2010.64741}, abstract = {The antioxidant activity of the ethanolic extract of brown propolis was determined by invitroantioxidant assays via 1,1-diphenyl-2-picryl-hydrazyl (DPPH·) free radical scavengingactivity and phosphomolybdenum method. The brown propolis extract had an effective DPPH·scavenging activity at 20-200ìg/ml concentrations. Moreover, the in-vivo experiments showedthat brown propolis extract has a powerful antioxidant and lipid peroxidation inhibitory activityin the liver tissues challenged with CCl4. On the other hand, we found that pretreatment of ratswith propolis extract protected gastric tissues against indomethacin-induced gastropathy asdemonstrated from reduction in the ulcer index, attenuation of histopathological changes andamelioration of the altered oxidative stress biomarkers like glutathione, thiobarbituric acidreactive substance levels and superoxide dismutase act ivi ty in gastric tissues. In conclusion,total ethanolic extract of brown propolis exposed major anti-oxidant and anti-ulcer activities.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_64741.html}, eprint = {https://bpsa.journals.ekb.eg/article_64741_f7dd5b4dd84896ec19d961cd9423bfed.pdf} } @article { author = {Abd El-Rasoul, S and Ahmed, Mahmoud}, title = {CHITOSAN POLYMER AS A COAT OF CALCIUM ALGINATE MICROCAPSULES LOADED BY NON-STEROIDAL ANTIINFLAMMATORY DRUG}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {33}, number = {2}, pages = {179-186}, year = {2010}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.2010.64750}, abstract = {In a trial to delay the release rate of diclofenac sodium from alginate coatedmicrocapsules, the use of a copolymer was suggested. Mixtures of polymers can have asignificant properties than that of individual polymer to achieve sustained releasemicrocapsules. On considering the negative charge of alginate and its ability to form polyioniccomplexes with a lowered tendency of erosion at higher pH value, a cationic polymer wasseeked. Chitosan (CS) was the one of choice due to the similarity of the saccharide structures ofchitosan and alginate that offers greater interaction between the two polymers and strongerinter-chains reactions relative to that between alginate and branched polymers such aspolylysine. The microcapsules prepared using 0.1 and 0.25% (CS) were spherical in shapewhile 0.4% (CS) formed microcapsules having rounded heads and tapered tails. The change inchitosan concentration had a non-significant effect on the particle size, the yield and the drugloading efficiency. The releaser ate of diclofenac sodium from microspheres showed a pHdependentprofile and was affected by chitosan coating. The release rate of diclofenac sodiumfrom chitosan coated alginate microcapsules at pH 7.4 was found to be faster than its release atpH 1.2. These results suggest this coating method to protect diclofenac sodium under acidicconditions and to permit a complete but controlled release of diclofenac sodium.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_64750.html}, eprint = {https://bpsa.journals.ekb.eg/article_64750_72fd511efa6aefbe3d6c1f94c2067ac6.pdf} } @article { author = {Abd El-Rasoul, S and Ahmed, Mahmoud}, title = {PREPARATION, CHARACTERIZATION AND IN-VITRO RELEASE OF CONTROLLED RELEASE KETOROLAC TROMETHAMINE CELLULOSE ACETATE BUTYRATE MICROSPHERES}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {33}, number = {2}, pages = {187-199}, year = {2010}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.2010.64752}, abstract = {The purpose of this study was to prepare and characterize controlled release ketorolactromethamine microspheres. To achieve this goal, cellulose acetate butyrate microspheresloaded by ketorolac tromethamine were prepared by the emulsion solvent evaporation method.The prepared ketorolac tromethamine microspheres were evaluated for their productionyields, particle size distribution, morphology, drug content and drug release characteristics.Thermal Gravimetric Analysis (TGA) were performed on the drug polymer systems in order toshed a light on the possibility of solid state changes of ketorolac tromethamine with CAB.A Box-Behnken design was selected for formulating ketorolac tromethamine microsphereswith revolution per minute (X1), drug-polymer ratio (X2) and span 80 percent (X3) asindependent variables. Three levels of the independent variables were used which equal to -1, 0and +1 for the above design. The values of the corresponding variables were 500, 700 and 900rpm for the machine speed; 1:1, 1:2 and 1:3 for drug-polymer ratio; 1%, 1.5% and 2% (w/w)for span 80 percent.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_64752.html}, eprint = {https://bpsa.journals.ekb.eg/article_64752_ac72035220441d3acbfb25b66a6c60e2.pdf} } @article { author = {Askal, H and Abdelmegeed, Osama and Abo El-Hamd, Mohamed}, title = {SPECTROPHOTOMETRIC AND SPECTROFLUORIMETRIC DETERMINATION OF 1,4-DIHYDROPYRIDINE DRUGS USING POTASSIUM PERMANGANATE AND CERIUM (IV) AMMONIUM SULPHATE}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {33}, number = {2}, pages = {201-215}, year = {2010}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.2010.64763}, abstract = {Simple and sensitive spectrophotometric and spectrofluorimetric methods have beendeveloped for determination of 1,4-dihydropyridine (1,4-DHP) drugs based on the oxidation ofthe investigated 1,4-DHP drugs with acidic KMnO4 (method I) or Ce (IV) (method II). The firstmethod is based on the decrease in the colour of the permanganate solution due to the presenceof the studied drug was measured at 525 nm. And the second method is based on monitoring thefluorescence of the produced cerium (III) at emission 355 nm (excitation at 255 nm). Allvariables that affect the performance of the proposed methods were carefully studied andoptimized. The analytical performance of the methods was validated according to InternationalConference of Harmonization guidelines. The proposed methods were applied successfully tothe determination of the drugs in commercial tablets and capsules. The results of the proposedprocedures were statistically and compared with those obtained by the reference methods.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_64763.html}, eprint = {https://bpsa.journals.ekb.eg/article_64763_7aeb70251a4a18f68de7a156172eb6f1.pdf} } @article { author = {Fetih, Gihan}, title = {FORMULATION AND CHARACTERIZATION OF GELUCIRE PELLETS FOR SUSTAINED RELEASE OF IBUPROFEN}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {33}, number = {2}, pages = {217-224}, year = {2010}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.2010.64767}, abstract = {The aim of the present study was to develop ibuprofen (IBU) - loaded pellets by meltsolidification technique using Gelucire 50/13 (GL) as a lipid carrier in different concentrations.This system was intended to prolong the drug release in order to minimize the drug relatedadverse effects and improve bioavailability in different gastrointestinal tract conditions. Theprepared pellets were evaluated using scanning electron microscopy (SEM), Infraredspectroscopy (IR), and Differential scanning calorimetry (DSC) studies. Process yield, drugloading, encapsulation efficiency, and particle size distribution were also investigated. Theeffect of agitation speed and amount of GL on pellets properties was evaluated. In-vitro drugrelease of ibuprofen from prepared pellets was studied in HCl buffer (pH1.2) for 2 hrs, and inphosphate buffer (pH 7.4) for up to 8 hrs. The obtained pellets were spherical in shape withsmooth surfaces; and GL showed no interaction with the drug. The release of drug from thepellets showed low percentage of drug release in pH 1.2. However, at pH 7.4 the obtainedresults showed that optimum levels of drug were released in a sustained manner.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_64767.html}, eprint = {https://bpsa.journals.ekb.eg/article_64767_7aafc79d92c347a3080a615c85c13d7d.pdf} } @article { author = {Ibraheim, Zedan and Gouda, Yaser}, title = {MINOR CONSTITUENTS FROM RUBIA CORDIFOLIA L. ROOT}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {33}, number = {2}, pages = {225-233}, year = {2010}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.2010.64774}, abstract = {Reinvestigation of the chloroform soluble fraction of the chloroform- methanol (1:1)extract of the dried roots of Rubia cordifolia L. using different chromatographic techniques ledto isolation of one new naphthohydroquinone dimer (1) and four known compounds identifiedas 3-ƒÒ -friedelinol (2), atraric acid (3), vanillic acid (4) and D-3-O-methoxy-chiro-inositol (5).The identification of the isolated compounds was carried out using different physical, chemicaland spectral methods of analysis.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_64774.html}, eprint = {https://bpsa.journals.ekb.eg/article_64774_252fea322c02acde57be798c773238d2.pdf} } @article { author = {Alorainy, Mohammad}, title = {DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS}, journal = {Bulletin of Pharmaceutical Sciences Assiut University}, volume = {33}, number = {2}, pages = {235-240}, year = {2010}, publisher = {Assiut University, Faculty of Pharmacy}, issn = {1110-0052}, eissn = {3009-7703}, doi = {10.21608/bfsa.2010.64783}, abstract = {The prevalence and trends of drug resistance of Mycobacterium tuberculosis at theKingdom of Saudi Arabia and other countries were reviewed. Drug resistance incidence of M.tuberculosis showed marked geographic variation from one country to the other ranged from 0to 18%. In Saudi Arabia, the pattern of resistance of M. tuberculosis also showed markedregional variation. The variability in the resistance rates of tuberculosis is dependent on thetime and location of the study as well as on the contribution of non-Saudi patients to each study.Multidrug-resistant M. tuberculosis (MDR-TB) was defined by Centers for Diseases Controland Prevention (CDC), the World Health Organization (WHO), and the International Unionagainst Tuberculosis and Lung Disease as resistance to at least isoniazid and rifampicin with orwithout resistance to other agents.}, keywords = {}, url = {https://bpsa.journals.ekb.eg/article_64783.html}, eprint = {https://bpsa.journals.ekb.eg/article_64783_c8ac6f8a5691e3ff9fc9b2688517c208.pdf} }