eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1997-12-31
20
2
105
112
10.21608/bfsa.1997.68747
68747
Original Article
EVALUATION OF THE MOLLUSCICIDAL ACTIVITIES OF ATRIPLEX STYLOSA AND AGAVE FEROX
Mortada El-Sayed
1
Hanan El-Nahas
2
Laboratory of Medicinal Chemistry, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt
Laboratory of Medicinal Chemistry, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt
The molluscicidal activities of aqueous suspension of Atriplex stylosa (Family Chenopodiaceae) and Agave ferox (Family Agavaceae were evaluated against Biomphalaria alexandrina, Bulinus truncates and Lymnaea cailliaudi snails, the intermediate hosts of Schistosomiasis and Fascioliasis (LC90 for A. stylosa were 180, 167 and 162 ppm while for A. ferox were 192, 185 and 179 ppm) within 24 hours against the three snails respectively. Also, screening of some different extracts of the two plants against B. alexandrina snails revealed that the methanol extracts of both plants were most active (LC90 was 80 ppm for A. stylosa and 92 ppm for A. ferox) within 24 hours. On the other hand, it was found that both plants are toxic against Schistosoma mansoni cercariae.
Studying the effect of some simulated field conditions of the aqueous suspension of the two plants such as (different water temperatures, sun radiation, mud particles, different exposure times and pH values) proved that the activities of both plants are nearly stable under these conditions, therefore, it is recommended to evaluate these plants in the field as molluscicides and to isolate their active constituents.
https://bpsa.journals.ekb.eg/article_68747_09e7ffc74db6a72d75829617e82f54bc.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1997-12-31
20
2
113
125
10.21608/bfsa.1997.68749
68749
Original Article
MACRO- AND MICROMORPHOLOGICAL CHARACTERS OF ABERIA CAFFRA (HOOK.f. & HARV.) WARB. CULTIVATED IN EGYPT. PART I: STEMS AND LEAVES
D. Bishay
1
H. Sayed
2
S. Youssef
3
R. Abd Elsalam
4
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The macro- and micromorphological character of the stems and leaves of Aberia caffra (Hook.f. & Harv.) Warb. were studied and found helpful in identifying them in both the entire and powdered forms.
https://bpsa.journals.ekb.eg/article_68749_7849e507071dd90bcf5e30048f6b6894.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1997-12-31
20
2
127
140
10.21608/bfsa.1997.68750
68750
Original Article
MACRO- AND MICROMORPHOLOGICAL CHARACTERS OF ABERIA CAFFRA (HOOK.f. & HARV.) WARB. CULTIVATED IN EGYPT. PART II: FLOWERS AND FRUITS
D. Bishay
1
H. Sayed
2
S. Youssef
3
R. Abd Elsalam
4
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The macro- and micromorphological character of both male and female flower, as well as fruit of Aberia caffra (Hook.f. & Harv.) Warb. are presented. They were found helpful in identifying them in both the entire and powdered forms.
https://bpsa.journals.ekb.eg/article_68750_db6461fb72eceded3179d32fa3231fd2.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1997-12-31
20
2
141
146
10.21608/bfsa.1997.68751
68751
Original Article
FORMULATION AND EVALUATION OF CONTROLLED RELEASE AMINOPHYLLINE MATRIX TABLETS
Ahmed Ali
1
Adel Ali
2
Fergany Mohammed
3
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Faculty of Pharmacy, Al-Isra University, Amman, Jordan
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Three matrix excipients namely: Hydroxypropylmethylcellulose (HPMC), sodium carboxymethyl cellulose (NaCMC) and egg albumin (EA) were utilized for the preparation of controlled release matrix tablets containing 200 mg of aminophylline. The prepared tablets were evaluated with respect to physical parameters and dissolution rate. All formulations showed acceptable physical parameters. The release rate was variable depending on the composition of the matrix tablet. There was no significant difference between the dissolution rates of the matrix tablets prepared with HPMC or EA. The lowest release rate was observed in case of the matrix tablets prepared using NaCMC either alone or in combination with either HPMC or EA. The dissolution data of the drug from most matrix tablets formulation were fitted to Higuchi diffusion model.
https://bpsa.journals.ekb.eg/article_68751_38f424fa54c94eecfa4cb72560ad3c17.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1997-12-31
20
2
147
153
10.21608/bfsa.1997.68754
68754
Original Article
MOLLUSCICIDAL SPIROSTANOL SAPONINS FROM AGAVE HETERACANTHA
Mortada El-Sayed
1
Laboratory of Medicinal Chemistry, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt
Four spirostanol saponin glycosides were isolated from the butanol fraction of the methanolic extract of the leaves of Agave heteracantha (Agavaceae). The structures of these saponins were elucidated by a combination of spectroscopic analysis and hydrolysis followed by identification of both aglycones as tigogenin and gitogenin as well as the sugar moieties. The four saponins exhibited strong molluscicidal activites against Biomphalaria alexandrina (LC90 = 10, 15, 7 and 9 ppm) and Lymnaea cailliaudi (LC90 = 8, 13, 5 and 6 ppm), the intermediate hosts of Schistosoma mansoni and Fasciola gigantica in Egypt respectively.
https://bpsa.journals.ekb.eg/article_68754_208fe32d7c2cf4cb913aaab081d7e7c7.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1997-12-31
20
2
155
161
10.21608/bfsa.1997.68755
68755
Original Article
SYNTHESIS AND INVESTIGATION OF MAO INHIBITORS: HYDRAZONES OF POTENTIAL BRAIN-SPECIFIC DELIVERY
Nawal El-Koussi
1
Hoda Hassan
2
Hassan Farag
3
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A series of 1-methyl-3-[N-(substituted benzalimino)carbamoyl] pyridinium iodide and their corresponding dihydropyridines were prepared by conventional methods. The prepared compounds were tested in vitro for their MAO inhibitory activity on liver mitochondria by kynuramine fluorimetric assay. The results showed that MAOI activity of quaternaries is more than the corresponding dihydro compounds.
https://bpsa.journals.ekb.eg/article_68755_41fad123339d72fc45e6de3c89aa0895.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1997-12-31
20
2
163
168
10.21608/bfsa.1997.68756
68756
Original Article
SESQUITERPENE LACTONES AND FLAVONOIDS FROM INULA BRITANNICA (L.)
Omar El-Towesy
1
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
From Inula britannica (L.) five known sesquiterpene lactones were isolated and identified as 4a,5b-epoxyeupatolide (1); 4a,5b-epoxydesacetylovatifolin (2); 5a-hydroxydehydroleucodin (3); 14-hydroxy-2-oxoguaia-1-(10)-3-dien-5a,11bH-12,6a-olide (4) and 2-oxo-8a,10b-dihydroxyguai-3-en-1-a,5a,6b,11bH-12,6-olide (5) in addition to three known flavonoids viz. apigenin (6), apigenin-7-O-b-glucopyranoside (7) and quercetin, 3',4'-dimethoxy-7-O-b-glucopyranoside (8). The structures of these compounds were depicted through spectral studies. All the isolated compounds were reported for the first time from the mentioned plant.
https://bpsa.journals.ekb.eg/article_68756_accf74d8d1f5504ba6aa5cafd37a145c.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1997-12-31
20
2
169
179
10.21608/bfsa.1997.68757
68757
Original Article
IN-VITRO TRANSFER, PERMEABILITY AND INCLUSION COMPLEXATION OF A NOVEL POTENT SYNTHETIC ANDROGEN, METHYL NORTESTOSTERONE ACETATE, COMPARED WITH TESTOSTERONE
Sayed Ahmed
1
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The solubility, dissolution, in-vitro transfer from aqueous to organic phase, and in-vitro permeability of a potent nortestosterone ester, methyl nortestosterone acetate (NTA), compared with testosterone (T) in the absence and in the presence of hydroxypropyl-b-cyclodextrin (HP-b-CD) were investigated. The phase solubility diagrams of both drugs revealed the formation 1:1 inclusion complexes with HP-b-CD of AL-type at 30°, 70° and 45°C. The solubility of NTA and T were increased approximately 7000 fold and 500 fold, respectively, in the presence of 0.12 M HP-b-CD at 37°C. NTA interacted more strongly with HP-b-CD than T, a fact that led to a much better enhancement in the dissolution rate. Such inclusion complexation led to noticeable decrease in the transfer rate of both androgens from the aqueous to the organic phase compared with the drug alone. Finally, it was found that HP-b-CD enhanced the in-vitro permeability of NTA and T from Klucel gel formulations.
https://bpsa.journals.ekb.eg/article_68757_f936284fd2938b637d9d04b0d75337fe.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1997-12-31
20
2
181
186
10.21608/bfsa.1997.68759
68759
FLAVONOID GLYCOSIDES FROM THE LEAVES OF SALVADORA PERSICA L.
A. Ali
1
M. Assaf
2
M. El-Shanawany
3
M. Kamel
4
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
From the leaves of Salvadora persica L. eleven flavonoidal glycosides are isolated and identified. Seven of them: Isorhamnetin-3-O-robinobioside, Kaempferol-3-O-robinobioxide, Narcissin, Kaempferol-3-Orutinoside, Isorhamnetin-3-O-b-galactoside, Astragalin and Isorhamnetin-3-O-b-D-glucoside are isolated for the first time form the genus Salvadora. While the others four are identified as: Isorhamnetin-3-(2,6-di-rhamnopyranosyl-galactopyranoside), Mauritianin, Isorhamnetin-3-O-(2-Glc-rhamnosylrutinoside) and Kaempferol-3-O-(2-Glc-rhamnosylrutinoside) and reported for the first time in family Salvadoraceae.
https://bpsa.journals.ekb.eg/article_68759_aee33861d6a080c03692ee7c076f3d53.pdf