eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1996-10-31
19
1
1
14
10.21608/bfsa.1996.68775
68775
Original Article
FORMULATION AND EVALUATION OF CONTROLLED RELEASE IBUPROFEN TABLETS
Eman Samy
1
Ahmed Abdel Zaher
2
Safaa Abdel Maksoud
3
Department of Industrial Pharmacy, Faculty of Pharmacy, Assuit University, Assiut, Egypt
Department of Pharmacology, Faculty of Medicine, Assuit University, Assiut, Egypt
Department of Histology, Faculty of Medicine, Assuit University, Assiut, Egypt
Controlled release ibuprofen tablets were prepared by coevaporation technique using Eudragit RSPM, ethylcellulose 20, Aerosil R972 and Aerosil 200 as carriers and Avicel pH102 as filler. The effect of different compression forces on the release rate of the drug was studied. The carriers used produce retardation in the release rate of ibuprofen in the following manner: Eudragit RSPM > ethylcellulose 20 > Aerosil R972 > Aerosil 200. The dependence of release rate (K) on hardness (H) may be approximated by the equation, Ln K = a H + b. The release mechanism follows zero order kinetic.
The antiinflammatory activity of the coevaporates was studied in albino rats using trypan-blue method. The coevaporates were also tested in albino mice for their analgesic activity using hot plate and p-benzoquinone induced writhing methods. The obtained results revealed that Eudragit RSPM and Aerosil 200 were the most effective in sustaining the antiinflammatory and analgesic actions of ibuprofen, while ethylcellulose 20 was the least effective. Histological examination of rat's stomach proved the efficiency of the tested coevaporates in inhibiting the ulcerogenic effects caused by the plain drug.
https://bpsa.journals.ekb.eg/article_68775_8ad1d5bfb2ac6e4b15530331306a460a.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1996-10-31
19
1
15
20
10.21608/bfsa.1996.68776
68776
Original Article
COUMARINS AND OTHER CONSTITUENTS FROM FERULA SINAICA BOISS GROWING IN EGYPT
Zedan Ibraheim
1
Omar Abdallah
2
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Reinvestigation of the constituents of the dried roots of Ferula sinaica Boiss resulted in the isolation of a new sesquiterpene-coumarin together with three known sesquiterpene-coumarins, two phenylpropanoiids one of them is new and one carotane sesquiterpene. The identification of the isolated compounds was carried out using spectral analysis including IR, 1H-NMR, 13C-NMR, 2D 1H-1H COSY and MS.
https://bpsa.journals.ekb.eg/article_68776_56309696432b96c7b7be0f4ee8f4586d.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1996-10-31
19
1
21
34
10.21608/bfsa.1996.68778
68778
Original Article
MACRO- AND MICROMORPHOLOGY OF STEMS AND LEAVES OF TERMINALIA ARJUNA (bedd.)
E. Backheet
1
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The macro- and micromorphology of the stems and leaves of Terminalia arjuna (Bedd.) are presented with the aim of finding their characters by which they could be identified and differentiated, both in the entire and powdered forms.
https://bpsa.journals.ekb.eg/article_68778_94661fb78b680d0d21353337742a067a.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1996-10-31
19
1
35
44
10.21608/bfsa.1996.68780
68780
Original Article
MACRO- AND MICROMORPHOLOGY OF STERCULIA RUPESTRIS BENTH. (LEAF AND STEM)
E. Desoky
1
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The macro- and micromorphology of the leaf and stem of Sterculia rupestris Benth., cultivated in Egypt have been investigated in order to determine the diagnostic feature by which each organ could be identified both in the entire and powdered forms.
https://bpsa.journals.ekb.eg/article_68780_dfc17b5a9ecf081532c64399172be9d0.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1996-10-31
19
1
45
52
10.21608/bfsa.1996.68782
68782
Original Article
INCLUSION COMPLEXATION OF BENZTHIAZIDE WITH CYCLODEXTRINS IN SOLUTION AND SOLID PHASE
Gamal El-Gendy
1
Ahmed Aly
2
A. El-Sayed
3
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Investigations were made to prepare the inclusion compounds of Benzthiazide (BTZ) with b-cyclodextrin (b-CD), g-cyclodextrin (g-CD) and dimethyl-b-cyclodextrin (DMCD) in solid powdered form by the freeze-drying and the grinding methods.
The freeze drying and grinding methods were successful in obtaining the inclusion compounds of BTZ with the cyclodextrins (CDs). All the inclusion compounds obtained via freeze drying and grinding methods were in powdered form. It was shown by X-ray diffractometery that the inclusion compounds obtained by the two methods were amorphous. Clear differences in infrared (IR) absorption spectroscopy and differential scanning calorimetry were observed between the inclusion compounds and the physical mixtures of BTZ-CDs.
Furthermore, inclusion complexation of BTZ with g-CD, DMCD and b-CD in aqueous solutions were confirmed by the solubility method. The solubility curves of BTZ-g-CD and BTZ-DMCD were typical AL type curves while the solubility curve with b-CD can be classified as type Ap. The apparent stability constants, Kc, were calculated from the slope and intercept of the solubility diagrams 1110 M-1, 3053 M-1 and 1268 M-1 respectively. The dissolution rate of BTZ from the inclusion complexes was much more rapid than that of the BTZ alone. The enhanced dissolution rate may be due to the decrease in crystallinity and the increase in apparent solubility of the drug of the freeze-dried and ground samples, as expected from X-ray diffractometery and solubility study.
https://bpsa.journals.ekb.eg/article_68782_512c4ff6b6295ced8aeadc7c80d955e0.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1996-10-31
19
1
53
62
10.21608/bfsa.1996.68783
68783
Original Article
ANALYTICAL STUDY OF SOME ANTIHISTAMINES WITH HAEMATOXYLIN REAGENT
Osama Abdelmageed
1
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The reaction between haematoxylin reagent and eight antihistaminic drugs (chlorpheniramine maleate, pheniramine maleate, cyproheptadine hydrochloride; astemizole, terfenadine, ranitidine hydrochloride, famotidine and cimitidine) was investigated and utilized as the basis for a new, simple and sensitive spectrophotometric procedure for their determinations. The procedure is based on the reaction of the methanolic solution of the anti-histaminic compounds with haematoxylin reagent in 3x10-3 M boric acid to give a reddish-violet colour (lmax 555 nm). The absorbance was linear with all compounds over the 5-200 µg/ml general concentration range of the final measured antihistamine base solution. A good correlation was found between log A (1%, 1 cm) and pka values for six of the studied drugs. The method can be applied successfully to the analysis of commercially available tablet formulations. No interference was observed due to additives which are commonly present in tablet formulations or coformulated compounds such as phenazone, phenazone salicylate, sodium salicylate paracetamol, propyphenazone and caffeine.
https://bpsa.journals.ekb.eg/article_68783_ab4d321a8be5778ff850e0bddd6f27c8.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1996-10-31
19
1
63
65
10.21608/bfsa.1996.68785
68785
Original Article
NON-ALKALOIDAL COMPOUNDS FROM BULBS OF CRINUM MOOREI
M. Kamel
1
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Three chromones viz. eugenin; 5,7-dihydroxy-2-methyl, chromone and 5,7-dihydroxy-6-methoxy-2,8-dimethyl chromone in addition to 4'-hydroxy-7-methoxy flavan and b-sitosterol have been isolated for the first time from bulbs of Crinum moorei. The structures of the isolated compounds have been determined by different spectroscopic methods and comparison with published data.
https://bpsa.journals.ekb.eg/article_68785_8c922c5abdba1dded82407d8c6258606.pdf