eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1994-07-31
17
1
1
15
10.21608/bfsa.1994.69783
69783
Original Article
MARCO- AND MICROMORPHOLOGY OF CRINUM MOOREI VAR. SCHMIDTII, HOOK F. CULTIVATED IN EGYPT. PART 1: ROOT, BULB (fleshy scale leaves) and foliage leaf
S. El-Mogahzy
1
H. Hassanean
2
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The detailed macro- and micromorphological characters of the root, bulb and leaf of crinum moorei Schmidtii, Hook. F., are studied with the aim to facilitate their identification in both entire and powdered forms, and to find out the diagnostic elements which call help in differentiating this species from the other closely related species of crinum.
https://bpsa.journals.ekb.eg/article_69783_c7ca3a94f95ac557e1ad035a7bae4088.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1994-07-31
17
1
17
25
10.21608/bfsa.1994.69784
69784
Original Article
SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME NEW 1,3,4-OXADIAZOLES AND 2-SUBSTITUTED AMINO-L,3,4-OXADIAZOLE DERIVATIVES CONTAINING BENZIMIDAZOLE MOIETY
F. Ashour
1
S. El-Hawash
2
M. Mahran
3
A. Yousry
4
A. Harnouda
5
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
Department of Microbiology, High Institute of Public Health, Alexandria University, Alexandria, Egypt
Department of Microbiology, High Institute of Public Health, Alexandria University, Alexandria, Egypt
New 2-[4-(3-acetyl-2-substituted- 2,3-dihydro-1,3,4-oxadiazol-5-yl)phenoxymethyl]-1H-bezimidazoles (V) and 2-[4-(3-acetyl-2-substituted-2,3-diydro-1,3,4-oxadiazol-5yl)phenoxymetyl]-1-methyl-1H-benzimidazoles (VI) were synthesized by cyclization of 2-[4-alkylidene or arylidenehydrazinocarbonyl)phenoxymethyl]-1H-benzimidazoles (III) or 2-[4-(alkylidene or arylidenehydrazinocarbonyl)phenoxymethyl]-1-methyl-1H-benzimidazoles (IV) with acetic anhydride. New series of 2-[4-substitutedamino-1,3,4-oxadiazol-5-yl)phenoxymethyl]-1H-benzimidazoles (IX) and 2-[4-substitutedamino-1,3 ,4-oxadiazol-5-yl)phenoxymethyl]-1-methyl-1H-benzimidazoles (X) were obtained by cyclodesulfurization of 2-[4-(substitutedthiocarbamoylhydrazinocarbonyl)phenoxymethyl]-1H-benzimidazoles (VII) or 2-[4-(substitutedthiocarbamoylhydrazi nocarbonyl)phenoxymethyl]-1-methyl-1H-benzimidazoles (VIII). The structure of the newly synthesized compounds were elucidated by elemental analysis, IR and 1H-NMR spectra. Their antimicrobial activity was studied.
https://bpsa.journals.ekb.eg/article_69784_2bd52c8f8e1e5b29bcb04ad1b7f9c9bf.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1994-07-31
17
1
27
39
10.21608/bfsa.1994.69785
69785
Original Article
DESIGN AND SYNTHESIS OF' SOME NEW 1H-1,2,4-TRIAZOLES OF POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES
Hoda Hassan
1
Abdel-Nasser El-Shorbagi
2
Nawal El-Koussi
3
Ahmed Abdel-Zaher
4
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt
Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
The synthesized 1H-1,2,4-triazoles (7a-c, 8a-c and 9a-c), a novel class of heterocyclic compounds of potential anti-inflammatory and analgesic activities, are of interest, since they present some differences compared to the classical non-steroidal anti-inflammatory agents. The anti-inflammatory activity of all derivatives was studied in albino rats using trypan-blue and kaolin-induced edema methods. The compounds were also tested in albino mice for their analgesic activity using the hot plate and p-benzoquinone-induced writhing methods. A correlation between the structures, pharmacological actions and the calculated partition coefficients of the products was studied.
https://bpsa.journals.ekb.eg/article_69785_b9714bd9ddd163282365165686e87757.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1994-07-31
17
1
41
48
10.21608/bfsa.1994.69786
69786
Original Article
DRUG RELEASE FROM PLURONIC GELS
Salwa Safwat
1
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The release rate of progesterone, dexamethasone, ethinylestradiol and a-methyldopa(MD) was determined in aqueous gels of pluronic surfactants (F-65, F-127, F-123) and the effects of concentration and temperature were investigated. The release of drugs from pluronic F-127 could be described by the diffusional model and the rate-controlling stage in the release process is diffusion of the dispersed drug through the matrix continuum. The release-rate decreased as the concentration of pluronic F-127 increased for both dexamethasone and progesterone; and increased as the molecular weight of the pluronic type increased (F-65 < F-123 < F-127) for ethinylestradiol.
While, the release rate of a-methyldopa(MD) dexamethasone and ethinylestradiol decreased as increasing concentration of the drug and increasing the temperature, we found that increasing progesterone concentration and temperature;increased the release rate.
https://bpsa.journals.ekb.eg/article_69786_7fcb9732490266093128517d12833be1.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1994-07-31
17
1
49
56
10.21608/bfsa.1994.69787
69787
Original Article
INFLUENCE OF -CYCLODEXTRIN ON THE NYSTATIN RELEASE FROM OINTMENTS AND ITS ANTIFUNGAL EFFECT
Salwa Safwat
1
Samia El-Gizawy
2
Ehsan Elsabour
3
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Microbiology, Faculty of Medicine, Assiut University, Assiut, Egypt
Thesolid complex of nystatin-g-cyclodextrin (g-CD) in a molar ratio 1:1 was prepared. Physico-chemical characteristics of the nystatin-g-CD) complex was studied by x-ray diffraction, differential scanning calorimetry and infrared spectroscopy. Absorption and hydrophilic (o/w) ointments were prepared, containing each of the intact drug, the g-CD complex and .the physical mixture of the drug with g-CD; respectively.
The in-vitro release of nystatin from both types of ointments was examined and the concentration of nystatin released was estimated by HPLC method using Cyclobond column-for the resolution of the drug. The release kinetic mechanism was found to follow both diffusion controlled and first-order kinetic mechanisms. The solid complex-prepared showed improved release from o/w rather than absorption ointment bases as well as enhanced antifungal effect against Candida Albicans.
https://bpsa.journals.ekb.eg/article_69787_33aaef1e6272a98dfb94ff7ef923e1d1.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1994-07-31
17
1
57
64
10.21608/bfsa.1994.69788
69788
Original Article
TEMAZEPAM--CYCLODEXTRIN AND TEMAZEPAM-MICROCRYSTALLINE CELLULOSE GROUND MIXTURES FORMULATED INTO TABLETS, CAPSULES AND SUPPOSITORIES
S. Saleh
1
S. Ahmed
2
M. Ahmed
3
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Temazepam-b-cyclodextrin and temazepam-microcrystalline cellulose ground mixtures were formulated into tablets, capsules and suppositories. The produced dosage forms were evaluated with regard to their physical properties and dissolution characteristic. Tablets containing temazepam-b-cyclodextrin or temazepam-microcrystalline cellulose ground mixtures showed reasonable physical properties andfaster dissolution characteristics compared to those containing untreated temazepam or ground alone one. Capsules containing Temazepam-b-cyclodextrin or temazepam-microcrystalline cellulose ground mixtures 'showed faster release characteristics compared to those containing untreated temazepam, the ground alone one or the. commercial temazepam capsule form studied. With regard to the-prepared suppositories, Witepsole H 15 gave rise to suppositories with a very slow release whereas, a mixture of PEG 1500 and PEG 400 (9:1 W/W) gave rise to suppositories with very fast release characteristics.
https://bpsa.journals.ekb.eg/article_69788_db4f83878bc8f7a2070b8ed264dc3290.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1994-07-31
17
1
65
71
10.21608/bfsa.1994.69789
69789
Original Article
SELECTIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS OF D-PENICILLAMINE BULK DRUG AND CAPSULES IN THE PRESENCE OF SOME PENICILLINS AND THEIR DEGRADATION PRODUCTS
Gamal Saleh
1
Hassan Askal
2
Osama Abdelmageed
3
Ibrahim Refaat
4
Department of Pharmaceutica1Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutica1Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutica1Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutica1Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Three simple, rapid and sensitive spectrophotometric methods for the assay of D-penicillamine in the presence of some penicillin preparations as well as common penicillin degradation products were carried out. These methods are based on the oxidation of penicillamine with ferric ion in aqueous solution. The indirect quantitation of the produced ferrous ions was carried out at 523, 690 and 510 nm for ferro-bipyridyl, ferro-ferricyanide and ferro-1,10-phenanthroline complexes respectively. All variables were studied to optimize the reaction conditions. Regression analysis of Beer's plot showed good correlation in a general concentration range of 1-10 mg D-penicillamine/ml. No interference could be observed from the presence of many structurally relevant compounds. In addition, common pharmaceutical adjuvants present incapsules did not interfere. The validity of the proposed methods was tested by analyzing artaminecapsules. Recoveries were 99.5 - 100.9%.
https://bpsa.journals.ekb.eg/article_69789_9c76c83e672295f015eaf952bb051208.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1994-07-31
17
1
73
79
10.21608/bfsa.1994.69790
69790
Original Article
PHARMACEUTICAL AND HISTOLOGICAL STUDIES OF NEW SOLUBLE DIAZEPAM
S. El-Harras
1
S. Shawky
2
E. Hafez
3
S. Shaker
4
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt
Lyophilization technique has been adopted to enhance the aqueous solubility of diazepam. Two hydrophilic polymers namely; polyvinyl pyrrolidone 44000 (PVP) and pluronic F-127 (PF-127) in different ratios were used as the adjuvents in preparing the freeze-dried samples. Of the tested ratios, diazepam: PVP (1:10) and diazepam: PF-127 (1:60) were found to gave the highest solubility of the drug.
The dissolution studies revealed that lyophilized diazepam samples required from 1-3 minutes to dissolve compared to 20 minutes in case of untreated drug.
Histological evaluations were performed after S.C. and I.M. injection into mice. A slight histological changes were induced. Consequently, the prepared lyophilized-diazepam product can be reconstituted with ease using phosphate buffer (pH 7.2) for parenteral administration, as well as it can met the requirement of zydis.
https://bpsa.journals.ekb.eg/article_69790_58489abecba065b2558a7130566deacd.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1994-07-31
17
1
81
86
10.21608/bfsa.1994.69791
69791
Original Article
EFFECT OF BLOCK COPOLYMERS ON THE DISSOLUTION OF SOME WATER-INSOLUBLE DRUGS: 1. NIFEDIPINE-PLURONIC F-127 SOLID DISPERSION SYSTEM
Sayed Khidr
1
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
The effect of pluronic F-127, a block copolymer, on enhancing the dissolution rate of water-insoluble drugs was studied. Solid dispersions of nifedipine, a model water-insoluble drug, with pluronic F-127 and PVP at different drug : polymer ratios were prepared using the solvent-evaporation method. The dissolution profiles of solid dispersion samples in distilled water at 37°C were compared to those using physical mixtures of the same composition.
The results showed that solid dispersion technique using both PVP and pluronic F-127 dramatically increased the dissolution rate of nifedipine.
X-ray and differential scanning calorometric (DSC) studies were performed on different samples in order to elucidate mechanism(s) of the dissolution enhancement effect exerted by both polymers. It was concluded that the increase in dissolution rate of nifedipine from the solid dispersion is due to the lack of the drug crystallinity in these formulations. This improvement in the drug release rate can lead to an improvement in its bioavailability.
https://bpsa.journals.ekb.eg/article_69791_540fdf29ee02b7b3cda010dbbf02b047.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1994-07-31
17
1
87
94
10.21608/bfsa.1994.69792
69792
Original Article
STUDY OF CHARGE-TRANSFER COMPLEXES BETWEEN IODINE AND SOME ANTIDEPRESSANTS
Ibrahim Refaat
1
Osama Abdelmageed
2
Hassan Askal
3
Gamal Saleh
4
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Molecular interactions between iodine and various antidepressants are investigated by UV/Vis spectroscopy. Iodine is found to form charge-transfer complexes (CTC) of n-type with these molecules. Beer's law is obeyed in the concentration range 0.5-30 mg/ml for the studied compounds. The values for the formation constants Kc of these iodinated complexes indicate a strong donor-acceptor interaction. These drugs can, therefore, be expected to interfere with thyroid metabolism. In addition, a good correlation between log € and some antidepressant parameters is found.
https://bpsa.journals.ekb.eg/article_69792_eb850a204bf045c5d95866e5468cad86.pdf