eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1988-12-31
11
2
165
175
10.21608/bfsa.1988.73506
73506
Original Article
PHYTOCHEMICAL STUDY OF CASSIA DIDYMOBOTRYA FRES. CULTIVATED IN EGYPT PART 1: STUDY OF QUINONES AND URACIL
S. El-Sayyad
1
A. Abdel-Baky
2
E. Backheet
3
K. Glombitza
4
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Institut fur Pharmazeutisches Biologie der Universität Bonn, West Germany
Phytochemical study of the contents of the different organs of C. didumobotrya Fres. Resulted in the isolation and characterization of chrusophanol, physcion, aloe-emodin, 2- methoxystypandron, fallacinol, and uracil.
Physcion, emodin, fallacinl and uracil were isolated for the first time from this plant.
The identification was based on physical, chemical and spectral studies including UV, IR, 1H, 13C-NMR and MS analysis. The 13C-NMR assignments of aloe-emodin are reported here for the first time.
https://bpsa.journals.ekb.eg/article_73506_a6fbec42f298b71ab3230880eee8d11a.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1988-12-31
11
2
176
184
10.21608/bfsa.1988.73507
73507
Original Article
INVESTIGATION OF THE FLAVONOID CONTENT OF LEAVES, STEMS AND FLOWERS OF EGYPTIAN POLYGONUM SALCIFOLIUM L.
S. Balbaa
1
M. Afifi
2
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
The investigation of the flavonoid content of the leaves, stems and flowers of polygonum salcifolium L. (Family: polygonaceae) was carried out adopting bothchromatographic and spectroscopic techniques. This study revealed the presence of kaempferol-7-O-rhamnoglucoside, quercetin-3-O-galactoside (hyperoside), orobol-7-O-glucoside and isorhamnetin-3-O-galactoside in all investigated parts.
https://bpsa.journals.ekb.eg/article_73507_5603a42c77a419990cd0069de456d190.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1988-12-31
11
2
185
195
10.21608/bfsa.1988.73509
73509
Original Article
INVESTIGATION OF FLOWER ANTHOCYANIN PIGMENTS OF ALTHEA ROSEA CAV. AND MALVA VISCOUS-ARBOREA L. GROWING IN EGYPT
M. Afifi
1
M. Karawya
2
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
Six anthocyanin pigment were isolated from Malvaviscous-arborea L. and five from Althea rosea cav. (Family: Malvaceae). The identification of these pigments was achieved by paper chromatography, acid and enzymatic hydrolysis and spectralanalysis. The study revealed the presence of cyanidin-3B-D-glycoxy-loside-5B-D-glucoside, cyanidin-3,5-B-D-diglucoside, Malvidin-3,5B-D-diglucoside, Malvidin-3-B-D-diglucoside, Delphinidin-3-B-D-glucoside and Pelargonidin-3-B-D-glactoside in the petals of Malvaviscous-arborea L. andcyanidin-3,7-B-D-diglucoside, cyaniding-3-B-D-glucoxyloside,Delphinidin-3-B-D-galactoside, petunidin-3-B-L-rhamnoside andpelargonidin-7-B-D-glucoside in the petals of Althea rosea cav.
https://bpsa.journals.ekb.eg/article_73509_e7adfb717d4e6f470a0de8a5a741d7b3.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1988-12-31
11
2
196
221
10.21608/bfsa.1988.73513
73513
Original Article
DISSOLUTION ENHANCEMENT OF THIACETAZONE I: VIA SURFACE HYDROPHILIZATION
S. Ibrahim
1
E. Hafez
2
T. El-Faham
3
F. Mohamed
4
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Hydrophilized systems of thiacetazone with different hydrophilic Viz., surfactants, polymers, sugar alcohols and isoniazid were prepared. The tested drug was intimately wetted with small volume of alcoholic carrier solution, and left aside to dry at room temperature. The wettability and dissolution rate tests of the hydrophilized systems and their corresponding physical mixtures were performed. Also, the effect of the tested carriers on the aqueous solubility of thiacetazone was investigated. The USPXX dissolution test, exhibited a pronounced increase in dissolution of thiacetazone from its hydrophilized systems as compared to that of their physical mixtures and pure drug. Generally, a direct correlation was found between the wettability and dissolution rates. Hydrophilized systems with surfactants gave the highest dissolution and good wettability next to isoniazid. Surfactants then followed in order by sugar alcohols and then by polymers. The effect of surfactants is directly proportional to the concentration. After 10 minutes the relative dissolution rate was 14.34, 13.86 or 14.43 for 5% w/w. Tween 40, 60 or Myrj 53 respectively. However, with the other carriers higher concentrations led to reduction in the dissolution enhancing effect. The results denote the potential use of this technique to enhance thiacetazone dissolution.
https://bpsa.journals.ekb.eg/article_73513_46e205695541ca7e46f859dce546535d.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1988-12-31
11
2
222
234
10.21608/bfsa.1988.73516
73516
Original Article
ANALYSIS OF SOME ANTI-INFLAMMATORY ARYLACETIC ACID DERIVATIVES THROUGH THE GRIESS REACTION
M. El-Kommos
1
K. Emara
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A simple, rapid and accurate method for the spectrophotometric determination of six anti-inflammatory arylacetic acid derivatives (Ibuprofen, naproxen, ketoprofen, indomethacin, pirprofen and flurbiprofen) in either the drug susbstances or in pharmaceutical formulations is proposed. The method is based on the development of the characteristic orange Griess pigment with sodium nitrite p-nitroaniline and 1-naphylamine. A linear correlation was found between absorbance at lmax of 470 nm and concentration. The colour is well developed by heating the mixture of the drug and reagents on a water-bath at 60°C dor 15 minutes. The resulting chromogen is stable for at least 12 hours. Results of analysis of the official (first three) compounds is bulk drugs and dosage forms are in good agreement with those of the B.P 1980 procedures.
https://bpsa.journals.ekb.eg/article_73516_b6a85f5438e2072cc422cf82faef3be2.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1988-12-31
11
2
235
247
10.21608/bfsa.1988.73517
73517
QUANTITATIVE MOLAR ABSORPTIVITY-STRUCTURE RELATIONSHIPS OF CERTAIN CATECHOLAMINES
A. Youssef
1
M. El-Kommos
2
H. Farag
3
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Molar absorptivities of six catecholamines (CA) are determined from their reactions with hydrochloric acid, boric acid molybdic acid, germanium dioxide, iron (II)-citrate and zirconyl chloride. Significant linear correlations are obtained between emax and the number of ligands. emax of most of the (CA) investigated shows a significant correlation with the molecular connectivity indices of the side chains and pka values. A dimeric state is suggested for (CA) in 0.1 N hydrochloric acid medium.
https://bpsa.journals.ekb.eg/article_73517_a315cec0fbde5088e4aef8427dc9915d.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1988-12-31
11
2
248
260
10.21608/bfsa.1988.73518
73518
Original Article
AVAILABILITY OF PHENYLEPHRINE HYDROCHLORIDE FROM OPHTHALMIC MULTIPLE EMULSIONS
A. Mohamed
1
S. Ismail
2
F. Habib
3
M. Attia
4
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Phenylephrine hydrochloride was formulated in different emulsion systems with and without viscolizers (methylcellulose and tylose). The diffusion coefficient of phenylephrine hydrochloride in different formulation has been determined. Results indicated that the diffusion coefficient of Phenylephrine hydrochloride from different systems decreased with increasing viscolizer concentration. The mydriatic and intraocular pressure, IOP, responses were followed after the application of the tested formulations to the rabbit's eye. Four parameters have been utilized to assess the performance of the drug formulations. These are the area under the curve AUC; the maximum response, MR; the time of maximum response. TMR; and the duration of drug action. DA. It was found that the most effective emulsion system appeared to be the multiple w/o/w emulsion containing 1% w/v methylcellulose followed by that containing 0.5% w/v tylose.
https://bpsa.journals.ekb.eg/article_73518_62452a18d62031b0b7f46047584a378b.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1988-12-31
11
2
261
272
10.21608/bfsa.1988.73520
73520
Original Article
DISSOLUTION BEHAVIOUR OF PROPYLTHIOURACIL POLYVINYLPYRROLIDONE SOLID DISPERSIONS
S. Abdel-Rahman
1
A. El-Sayed
2
A. Aboutaleb
3
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The objective of the present study was to investigate the influence of variation of the molecular weight and the proportion of polyvinylpyrrolidone (PVPs) on the dissolution of propylthiouracil (Pt) as a model of sparingly soluble drugs dispersed in highly soluble polymers. Solid dispersions of Pt-PVP were prepared by the solvent method. The dissolution behavior was determined as a function of the molecular weight of PVP and the drug-to-carrier ratio. Three PVP molecular weight fractions were used, namely, PVP 10.000, PVP 40.000 and PVP 360.000. The drug-PVP percentages used were 10, 20, 40, 60 and 90%w/w. Enhancement of dissolution rate was observed for all solid dispersion systems compared to the drug alone or the physical mixtures. The dissolution rate was increased with increasing the proportion of PVP to the drug. Generally, the enhancement of the dissolution rate was decreased in the order: PVP 10.000 > PVP 40.000 > PVP 360.000. Differential scanning calorimetry (DSC) reveals a decrease in the melting point of Pt due to retardation of drug nucleation in the PVP matrix. X-ray diffractometry of the highest dissolution rate solid dispersion indicates the presence of Pt in an amorphous state in the carrier.
https://bpsa.journals.ekb.eg/article_73520_0e1350c9ca899ce0b040edba16539b61.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1988-12-31
11
2
273
280
10.21608/bfsa.1988.73522
73522
Original Article
PYRROLOPHENANTHRIDONE ALKALOIDS FROM CRINUM AUGUSTUM ROX. BULBS.
A. Ali
1
M. Ramadan
2
M. Abdel-Hafiz
3
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Three pyrrolophenanthridone alkaloids voz, hippadine, pratorimine and pratorinine were isolated from the chloroformic fraction of the ethanolic extract of C. augustum Rox. bulbs. In addition (-)4-hydroxy-7-methoxy flavan was also isolated.
The identity of these compounds was confirmed through determining their physical and spectral data.
https://bpsa.journals.ekb.eg/article_73522_7c5fbb36d47018e43d86017d7463adca.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1988-12-31
11
2
281
289
10.21608/bfsa.1988.73524
73524
Original Article
MICROCHEMICAL IDENTIFICATION AND DIFFERENTIATION OF AMARYLLIDACEAE ALKALOIDS PART II: TRISPHERIDINE, 6--ETHOXYBUPHANISINE, 6--ETHOXYCRININE, 3-O-ACETYLPOWELLINE, 3-O-ACETYLCRININE, CHERYLLINE, FLEXININE, BULBISINE AND AUGUSTISINE
A. Ali
1
M. Ramadan
2
M. Abdel-Hafiz
3
O. Abdallah
4
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut , Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut , Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut , Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut , Egypt
Microchemical identification of nine minor Amaryllidaceae alkaloids, Trispheridine, 6-a-ethoxybuphanisine, 6-a-ethoxycrinine, 3-O-acetylpowelline, 3-O-acetylcrinine, Cherylline, flexinine, bulbisine and augustisine by microcrystal techniques and colour reactions is described.
https://bpsa.journals.ekb.eg/article_73524_38fa11bf6274cf74932fc1232fc094f7.pdf