eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
1
13
10.21608/bfsa.1986.74483
74483
Original Article
UTILITY OF XANTHYDROL FOR THE SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN PHARMACEUTICAL PHENOLS
Michael El-Kommos
1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The reaction of xanthydrol with phenols was applied for the determination of thymol, guaiacol, morin and naringenin, out of 30 phenolic compounds tested. Mixture of methanolic solutions of the phenol and xanthydrol was heated in presence of hydrochloric acid for 10 minutes on a water bath. The lmax of the coloured chromogen was located in the vicinity of 485 nm (orange) to 540 nm (violet). Molar absorptivities range from 1.0x103 to 4.3x103. A linear correlation was found between absorbance at lmax and concentration in the range of 5-40 mcg ml-1 (for thymol), 20-100 mcg ml-1 (for guaiacol) and 20-150 mcg ml-1 (for morin and naringenin).
https://bpsa.journals.ekb.eg/article_74483_de504155e30245f4e4cc54297321a369.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
14
29
10.21608/bfsa.1986.74571
74571
Original Article
IN-VIVO ELIMINATION OF DIHYDROPYRIDINE DRUG DELIVERY CARRIERS FROM BRAIN AND BLOOD OF RATS
N. Bodor
1
M. El-Kommos
2
Ch. Nath
3
Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, U.S.A
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, U.S.A
The dihydropyridine « pyridinium salt redox delivery system, used for specific delivery and sustained release of drugs in the brain was studied. The rates of elimination of the ester and acid metabolites of l-methyl- 3-(ethoxycarbonyl)-1,4-dihydrpyridine and of 1-(2-ethoxycarbonyl) ethyl-1,4-dihydronicotinamide from brain and blood of rats after systemic administration of dihydro carrier-ethanol couples were investigated, taking ethanol as a model drug. It was found that the quaternary species are eliminated relatively fast, which supports the hypothesis for existence of an active transport mechanism for eliminating organic ions from the brain. The results can serve as a primary evidence for the suggestion that the carrier and its metabolites will not impair central nervous system functions.
https://bpsa.journals.ekb.eg/article_74571_119f3d6afd326762b7403b119de74903.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
30
49
10.21608/bfsa.1986.74572
74572
Original Article
BIOAVAILABILITY AND EROSIVE ACTIVITY OF SOME NON-STEROIDAL ANTI-INFLAMMATORY DRUGS SOLID-DISPERSIONS
E. Ramadan
1
A. G. Abd El-Gawad
2
A. Nouh
3
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
Solid dispersions of mefenamic acid, azapropazone, glafenine and floctafenine were prepared with PVP K25 and PEG 6000 in a ratio of 1:1 w/w. Bioavailability and erosive activity of these drugs were investigated using their solid dispersions. The obtained results revealed that the coprecipitate of such drugs with PVP enhances their bioavailability and significantly inhibits the ulcerogenic effect of the drugs under investigation. However, solid dispersions with PEG enhance bioavailability but slightly reduce their gastric ulceration.
https://bpsa.journals.ekb.eg/article_74572_6d78c84bd7b259f3e3267e55929ee342.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
50
65
10.21608/bfsa.1986.74573
74573
Original Article
FORMULATION AND EVALUATION OF CERTAIN ANTI-INFLAMMATORY DRUGS FOR TOPICAL APPLICATION. 1- OINTMENT FORMS
S. El-Shanawany
1
S. Safwat
2
S. Ibrahim
3
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The influence of type of vehicle on the in-vitro and anti-inflammatory effect of flufenamic and mefenamic acids has been studied. The vehicle investigated consisted of: water soluble base, an absorption base and two emulsion bases (O/W and W/O).
In-vitro release was evaluated using a diffusion assembly fitted with Fischer cellulose membrane (30/32) as diffusion barrier. Phosphate buffer of pH 6.8 at 35° C (±2) was used as release medium.
The results revealed that, the rate and amount of drug released was greatly affected by the type of base and nature of drug. The ointment bases can be arranged according to in-vitro release for both flufenamic and mefenamic acids as follows: water-soluble base > water-in oil emulsion base > oil in-water emulsion base > absorption base. Anti-inflammatory effect was studied on inflamed tissue of albino rabbit. The selected ointment bases were uniformly spread over the shaved inflamed back skin of rabbit for several days. The ointment bases can be arranged in descending order according to anti-inflammatory effect after topical application to inflamed tissue as follows: Absorption base > water in-oil emulsion base > oil-in-water emulsion base> water soluble base. Trials to find out any correlation between in-vitro release and anti-inflammatory effect for both flufenamic and mefenamic acids were carried out. It was found that there is only correlation between in-vitro release and anti-inflammatory effect for emulsion base (W/O, O/W) for both flufenamic and mefenamic acids.
https://bpsa.journals.ekb.eg/article_74573_db6c8485ad9ebb5b19bf4fb1e4a71be2.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
66
77
10.21608/bfsa.1986.74575
74575
Original Article
SYNTHESIS AND ANTIBACTERIAL TESTING OF SOME NEW SELENADIAZOLE AND THIADIAZOLE CONTAINING AMINO ACID MOIETIES
B. Bayoumi
1
M. Abd-Alla
2
A. Ahmed
3
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt
Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Several 4-{4-(substitutedglycylamino)-phenyl}-1,2,3-selenadiazols (IV) and 4{4-(substitutedglycylamino)phenyl}-1,2,3-thiadiazoles (V) were prepared for evaluation of their antimicrobial activity. 4-chloroacetylaminoacetophenone (I) when reacted with different amines gave 4-glycylaminoacetophenone derivatives (II), Condensation of II with semicarbazide furnished the corresponding semicrabazones (III). Oxidative cyclization of (III) either by selenium dioxide or thionyl chloride afforded IV and V respectively.
https://bpsa.journals.ekb.eg/article_74575_b7e2a031dc3225d073e5aa152f774a1c.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
78
91
10.21608/bfsa.1986.74578
74578
Original Article
SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME N-SUBSTITUTED-N'-(2-METHYL-4-OXOQUINAZOLIN-3-YL) OXAMIDES
A. Abdel-Alim
1
S. Hussein
2
H. El-Bitar
3
R. Abdel-Aal
4
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt
Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt
Fourteen new oxamides were synthesized by amidation of ethyl N-(2-methyl-4-oxoquinazolin-3-yl) oxamate with the appropriate amines. Preliminary anticonvulsant activity of five oxamides was evaluated, Correlation of activity with structure of the test compounds is also discussed.
https://bpsa.journals.ekb.eg/article_74578_11bd6aa92ab6f51c5a8aaedd6e8d777d.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
92
104
10.21608/bfsa.1986.74580
74580
Original Article
TITRIMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF MEBENDAZOLE AND FLUBENDAZOLE USING N-BROMOSUCCINIMIDE
F. Mohamed
1
M. Sidhom
2
S. Hussein
3
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Titrimetric and spectrophotometric determination methods are described for mebendazole and flubendazole in dosage forms.
The first method depends upon addition of an excess of standard N-bromosuccinimide (NBS) and after the specified time, the residual reagent is determined iodometrically. This procedure permits semi-micro determination (3-30 mg) of the drug.
An alternative procedure involves measurement of the colour produced after reaction with N-bromosuccinimide (lmax 465 nm). The stoichiometry of the reaction was studied and found 1:1 for mebendazole-
NBS and 1:2 for flubendazole-NBS. The methods were applied successfully for the analysis of either of the two drugs in some formulations. Average recoveries ranging from 98.70±1.64 to 101.94±0.82 for titrimetric and from 97.5 ± 0.65 to 101.30± 0.55 for spectrophotometric methods were obtained. The methods were compared with U.S.P. XX method in case of mebendazole and were found in good agreement.
https://bpsa.journals.ekb.eg/article_74580_58a88cd1fc377dd09e6d5c6ddb80cc80.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
105
118
10.21608/bfsa.1986.74582
74582
Original Article
SYNTHESIS OF SOME 2,7-DIAZABICYCLO {4.l.0} HEPT-3-ENE DERIVATIVES WITH ANALGESIC AND ANTICOCCIDIAL ACTIVITY
H. Farag
1
A. Abdel-Alim
2
H. Hassan
3
H. Hemaiat-Allah
4
R. Abdel-Aal
5
A. El-Badr
6
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt
Department of Parasitology, Faculty of Medicine, Assiut University, Assiut, Egypt
The 1,3-dipolar cycloaddition reaction of arylsulphonyl azides to 1,3-disubstituted-1,4-dihydropyridines afforded 2,7-diazabieyclo {4.1.0} hept-3-ene derivatives (III).These compounds exhibited more significant analgesic and anticoccidial activities than aspirin and sulphaguanidine respectively.
https://bpsa.journals.ekb.eg/article_74582_34c0371da8f6cbb25fa892793cdee2bc.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
119
143
10.21608/bfsa.1986.74583
74583
Original Article
EFFECT OF pH AND ORGANIC HYDROXYLATED ADDITIVES ON N-DESMETHYLDIAZEPAM SOLUBILIZATION BY NON-IONIC SURFACTANTS
A. Aboutaleb
1
Aly Abdel Rahman
2
E. Samy
3
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
N-desmethyldiazepam, was solubilized in different non-ionic surfactant solutions including members of polysorbates, Myrjs, Eumulgins and Brijs at 25 and 35 C.
Polysorbate 80 was more efficient in solubilizing the drug than polysorbate 20 and Brij 35 was more efficient than Brij 58. On the other hand, Eumulgin C1000 was found to be more efficient than Eumulgin C1500 and Myri 52 was found to be more efficient than Myrj 53 and Myrj 59 respectively.
Always raising the temperature of the investigated solutions caused a positive temperature effect and a decrease in Km values.
Adjusting the pH of Eumulgin and Brij solutions caused a gradual decrease in the quantity of the drug solubilized by raising the pH from
pH 4.0 to 7.4.
Theoretical treatment to quantify the role of both the core and the capsular regions of the micelle in N-desmethyldiazepam solubilization showed that the core of the micelle plays the most important role in solubilizing the drug.
The drug was solubilized in Eumulgin and Brij series containing 5 and 10% w/v of propylene glycol, glycerol, polyethylene glycol 400 (PEG 400) and polyethylene glycol 4000 (PEG 4000). The incorporation of propylene glycol, glycerol and PEG 400 or 4000 increased the solubilizing efficiencies of the surfactants toward the drug at 25 C.
Incorporation of 5% w/v of these additives in the tested Eumulgin and Brij solutions caused an increase in the Km values of the drug and the revrese is true for 10% w/v of these additives.
https://bpsa.journals.ekb.eg/article_74583_103433ad1e827257d3a0b942d23388ae.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
144
156
10.21608/bfsa.1986.74586
74586
Original Article
ON THE INTERACTION BETWEEN RIFAMPICIN AND MACROMOLECULES 1- POLYSORBATES
F. Habib
1
S. lsmail
2
S. El-Shanawany
3
E. Fouad
4
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The permeation rates of rifampicin through a standard cellophane membrane were investigated in presence of different polysorbates. The surfactants were used in a concentration range of 0.2-0.6% w/v. The data revealed that as the surfactant concentration was increased, the diffusion rates were found to be decreased. This was explained on the basis that as the surfactant concentration was increased, the partial volume fraction was consequently increased and a large amount of rifampicin was incorporated inside the micellar core. These incorporated rifampicin molecules are not ready to permeate through the membrane. The Langmuir plots as well as spectrophotometric analysis indicate that a complex formed between rifampicin and the tested polysorbates. This complex is not ready, also, to penetrate through the membrane. It was found that the limiting adsorption capacities of surfactants were almost the same. This was explained on the basis that they are characterized by having the same number of oxyethylene unites.
https://bpsa.journals.ekb.eg/article_74586_100c8068521de79efb47b0aeed141f72.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
157
171
10.21608/bfsa.1986.74587
74587
Original Article
INTERACTION OF 1,4-BENZODIAZEPINES WITH HYDROPHILIC MACROMOLECULES: V- WETTABILITY OF MODIFIED TEMAZEPAM CRYSTALS
B. Mulley
1
A. Aboutaleb
2
Aly Abdel Rahman
3
S. Ahmed
4
School of Pharmacy, Bradford University, U.K
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Wettability of temazepam crystals, crystallized from different concentrations of polysorbate 80 and cetomacrogol 1000 was evaluated quantitatively by measuring the contact angles on compressed discs of the crystallized drug. Increasing the concentration of the surfactant from which the drug was crystallized leads to increase in wettability. A direct correlation was found between the wettability of the drug and its dissolution.
An agreement was observed between the values of the contact angles measured using the adopted and the photographic methods.
The effect of time on the contact angle values was also investigated.
https://bpsa.journals.ekb.eg/article_74587_79f7f9367ade4ea268f7fa01fd546e5b.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
172
186
10.21608/bfsa.1986.74588
74588
Original Article
PREFORMULATION STUDIES ON DIRECTLY COMPRESSED TEMAZEPAM TABLETS
A. Aboutaleb
1
A. Abdel Rahman
2
M. Ahmed
3
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Temazepam, a benzodiazepine derivative, was prepared in directly compressed tablets using Avicel, Anhydrous Lactose (A.H.L.), STA-Rx 1500, Emcompress and Compactrol. It was found that A.H.L. represents the most suitable single vehicle while Avicel : STA-RX 1:1 blend was the most suitable blend for the preparation of temazepam tablets. STA-RX 1500 and its blends with the other used vehicles were shown to give the highest dissolution. The most uniform tablets were produced on using Emcompress alone or as a binary blend with Avicel (1:1) as directly compressible vehicles.
https://bpsa.journals.ekb.eg/article_74588_802ff0024907baeaceb1e84e59fd72fe.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
187
209
10.21608/bfsa.1986.74589
74589
Original Article
MACRO-AND MICROMORPHOLOGY OF SALVIA FARINACEA BENTH (ROOT AND FLOWER)
A. Aly
1
D. Bishay
2
M. El-Shanawany
3
M. Kamel
4
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The macro- and micromorphology of the root and flower of Salvia Farinacea Benth Cultivated in Egypt are presented with the view of determining the diagnostic features by which these organs can be identified both in the entire and powdered forms.
https://bpsa.journals.ekb.eg/article_74589_0d6724132a71eab871eb33b7a09372b1.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
1986-12-31
9
2
210
231
10.21608/bfsa.1986.74590
74590
Original Article
MACRO-AND MICROMORPHOLOGY OF TABEBUIA PENTAPHYLLA HEMSL. PART 1: THE STEM AND LEAF
D. Bishay
1
S. Ross
2
A. Abdel-Baki
3
Z. Ebrahim
4
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The macro-and micromorphology of the stem and leaf of Tabebuia pentaphylla hemsl, cultivated in Egypt at Aswan botanical garden have been investigated in order to determine the diagnostic features by which each organ could be identified both in the entire and powdered forms.
https://bpsa.journals.ekb.eg/article_74590_233ab7d3f668e50c6694cdad208f0795.pdf