eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
2001-06-30
24
1
1
6
10.21608/bfsa.2001.65693
65693
Original Article
Studies on the constituents of the leaves of Acer negundo (L.)
E. Backheet
1
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Kaempferol-3,7-diglucoside, Kaempferol-3-O-β-D-rutinoside, isorhamnetin-3-O-β-D-rutinoside, cinnamic acid, 5,7,3',4'-tetrahydroxyisoflavone and stigmasterol-3-O-β-D-glucoside were isolated from Et acetate and hexane fractions of ethanol ext. of the leaves of Acer negundo (L.). Identification of these compds. has been established by spectral evidence (UV, IR, MS, 1H- and 13C-NMR).
https://bpsa.journals.ekb.eg/article_65693_5362c3ca68358795675b668d0885d7ae.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
2001-06-30
24
1
7
20
10.21608/bfsa.2001.65750
65750
Original Article
Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic
A. El-Shorbagi
1
A. Hayallah
2
N. Omar
3
A. Ahmed
4
Department of Pharmaceutial Organic Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71526, Egypt
Department of Pharmaceutial Organic Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71526, Egypt
Department of Pharmaceutial Organic Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71526, Egypt
Department of Pharmaceutial Organic Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71526, Egypt
The present work reports on the synthesis and preliminary pharmacol. investigation of new 3-aryl-6,7-dimethyl-9-substituted thiazolo[3,2-a]benzimidazolium salts. These derivs. were synthesized by reacting the 3-aryl-6,7-dimethylthiazolo[3,2-a]benzimidazoles with the appropriate quaternizing agent. The latter compds. were, in turn prepd. by cyclodehydration of 5,6-dimethyl-2-(phenacylthio)benzimidazoles in polyphosphoric acid (PPA). The latter derivs. were obtained by the reaction of 5,6-dimethylbenzimidazole-2-thione with the appropriate phenacyl bromide. Some of the tested compds. have shown a pronounced hypoglycemic activity. The results do permit the assignment of compds. having N9-phenacyl entity as promising antidiabetic agents.
https://bpsa.journals.ekb.eg/article_65750_e7b82e5fc32ce657dc2739bc7693bf0f.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
2001-06-30
24
1
21
27
10.21608/bfsa.2001.65755
65755
Original Article
Phytochemical study of the constituents of the leaves of Ficus infectoria (Roxb.)
H. Sayed
1
E. Backheet
2
A. Ahmed
3
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
α-Amyrin, stigmasterol, bergapten, stigmasterol-3-O-β-D-glucoside, kaempferol-3-O-β-D-glucoside, benzyl-glucoside, quercetin-3-O-β-D-glucoside, 6-hydroxykaempferol-7-O-β-D-glucoside, and quercetin-3-O-β-D-rutinoside were isolated for the first time from the ethanolic ext. of the leaves of Ficus infectoria (Roxb.) cultivated in Egypt. Identification of these compds. has been established by phys. and spectral data (UV, IR, MS, 1H- and 13C-NMR) as well as by comparison with authentic samples.
https://bpsa.journals.ekb.eg/article_65755_8b962edd989ac9926072f46d66a408e6.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
2001-06-30
24
1
29
39
10.21608/bfsa.2001.65761
65761
Original Article
The effect of oral administration of Nigella sativa L. seeds and oil on some blood parameters
Z. Ibraheim,
1
A. Aly
2
A. Naddaf
3
Faculty of Pharmacy, Al-Israa University, Amman, Jordan P.O. BOX 621286-Amman, Al-Shiliyyab (11162)
Faculty of Pharmacy, Al-Israa University, Amman, Jordan P.O. BOX 621286-Amman, Al-Shiliyyab (11162)
Faculty of Pharmacy, Al-Israa University, Amman, Jordan P.O. BOX 621286-Amman, Al-Shiliyyab (11162)
A comparative study was carried about the effects of two weeks daily ingestion of 2 g of Nigella sativa L. seeds cultivated in Jordan and the equiv. amt. of the formulated oil prepd. by surface solid dispersion method on the blood levels of glucose, cholesterol, high d. lipoprotein (HDL), and other parameters such as: creatinine, prolactin, creatine kinase (CK) activities and RBCs, WBCs, platelets, Hb, and clotting time. The study was carried on male pharmacy students volunteers of an av. age of 22 yr. Ten students each administered two capsules contg. 500 mg Nigella sativa crushed seeds twice daily (group I) and another group of ten students (group II) received one capsule contg. an equiv. amt. of the oil twice daily for two weeks. Blood samples were taken from each student one week before administration, one week and two weeks after administration. Both crushed seeds and the oil produced a significant decrease in blood glucose, cholesterol, and creatinine level, meanwhile there was an increase in high d. lipoprotein. The oil produced a significant lowering effect on prolactin level (P < 0.05) while the crushed seeds exhibited a significant increase in clotting time (P < 0.01) after one week and continued for two weeks of administration. Insignificant effects were obsd. on RBCs, WBCs, platelets, Hb and creatine kinase activity. The phytochem. screening of the dried powd. seeds was done and the physicochem. consts. of the oil were detd. Column chromatog. of unsaponifiable matter results in the isolation of β-sitosterol and oleanolic acid as the main constituents.
https://bpsa.journals.ekb.eg/article_65761_01d6902bb7b4fd31cddd1c0a897e964c.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
2001-06-30
24
1
41
45
10.21608/bfsa.2001.65763
65763
Original Article
Non alkaloidal constituents from Crinum bulbispermum bulbs
A. Khalifa
1
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
From the bulbs of Crinum bulbispermum Milne, four non alkaloidal compds. were isolated viz, 4,4'-dihydroxy-2-methoxy-chalcone, and 4'-hydroxy-7-methoxy-flavone, and two new compds. identified as β-(3,4-dimethoxyphenyl)-α,β-ethanediol and p-hydroxybenzene acetic acid Et ester. The structures of the isolated compds. were established by spectral evidence.
https://bpsa.journals.ekb.eg/article_65763_b6ea3d1ba5bd11aa7a35ae54690e62ec.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
2001-06-30
24
1
47
54
10.21608/bfsa.2001.65773
65773
Original Article
Formulation and evaluation of ciprofloxacin hydrochloride suppositories
M. Hassan
1
N. Mahfouz
2
Departmeni of Pharmaceutics
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiui University
Formulation of the antibiotic, ciprofloxacin hydrochloride suppositories was carried out using different semisynthetic lipophilic bases as suppocire AM, suppocire CM, Novata B, Novata BD, Witepsol W35, and natural lipophilic base as Cocoa butter. The in-vitro release study of 100 mg ciprofloxacin hydrochloride suppository from these bases was performed in distd. water at 37° using thermostatically controlled mech. shaker water bath and the drug was measured at 278 nm. The results obtained revealed that suppocire AM gave the highest release rate followed by Novata BD, Novata B, Witepsol W35, Cocoa butter and Suppocire CM resp. The bioavailability of ciprofloxacin hydrochloride from suppositories contg. 100 mg of the drug after rectal administration in rabbits (1.5-2 kg), was carried out. HPLC procedures were adopted for the detn. of drug in plasma. The results obtained revealed that it was in agreement with the in-vitro data. The results showed that the drug was regularly absorbed and provided AUC ranging between 10.3 to 20.23 μ.hr./mL. Other pharmacokinetic parameters as Cmax, Tmax, Ka, Ke,
https://bpsa.journals.ekb.eg/article_65773_f0fab57389a3de0d16b28560b7fd0339.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
2001-06-30
24
1
55
64
10.21608/bfsa.2001.65795
65795
Original Article
Preparation and in-vitro evaluation of oral controlled-release matrix tablets containing diclofenac sodium
F. Mohammed
1
M. Hassan
2
M. Fathy
3
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Egypt
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Egypt
Controlled-release matrix tablets contg. 100 mg-diclofenac sodium were successfully prepd. using egg albumin and three matrixes forming materials namely, sodium CM-cellulose (NaCMC), hydroxypropylmethyl cellulose (HPMC) and Eudragit RS. The prepd. tablets were evaluated for their phys. parameters and the drug release rate. All the prepd. tablet formulations showed acceptable phys. parameters. The release rate was variable depending on the compn. of the matrix tablet and pH of the dissoln. medium. The release profiles and the release kinetics were compared with two com. available sustained-release tablet formulations of diclofenac sodium, Voltaren SR 100 (Ciba Geigy, USA) and Diclofen SR 100 (The United Pharm. Co., Jordan). The drug release data was fitted to various kinetic models. The drug release from all the tested formulations could be described by the diffusion mechanisms. Tablets prepd. with either egg albumin or combination of egg albumin and NaCMC gave release kinetics that were not significantly different from the com. formulations. Based on exptl. results, prepn. of controlled-release matrix tablets of diclofenac sodium using egg albumin is promising
https://bpsa.journals.ekb.eg/article_65795_0857815af2e4560c3ef5713938444b5e.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
2001-06-30
24
1
65
71
10.21608/bfsa.2001.65901
65901
Original Article
Effects of formulations and penetration enhancers on the diffusional parameters for the percutaneous absorption of propranolol hydrochloride
K. Khaled
1
Y. El-Sayed
2
I. Al-Bawardi
3
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Egypt
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
Propranolol hydrochloride, the com. available form of propranolol, was formulated as gels using different cellulose polymers viz. methylcellulose, CM-cellulose, and hydroxypropyl methylcellulose (HPMC). In vitro percutaneous absorption study of the gels was conducted using improved franz diffusion cells and rabbit skin as a membrane. The highest extent of drug penetration was obtained upon using HPMC gel formulation. Therefore, the influence of drug concn. on its percutaneous absorption was investigated utilizing HPMC gel formulation. The extent of drug percutaneous absorption was found to increase as drug concn. increases. Anal. of the diffusional parameters, govern the skin penetration process, revealed that diffusion coeff. of the drug did not change as drug concn. varies. On the other hand, the apparent permeability coeff., and the apparent partition coeff., showed dependency on drug concn. The limit value of the partition coeff. was detd., graphically, and found to be 0.2411. The influence of skin penetration enhancers, such as Azone, n-decyl alc., and 1,8-cineol, on the percutaneous absorption of the drug was studied. An overall low enhancing effect (max. of 5.7-fold compared to a control) was obtained using 1,8-cineol. This finding was attributed to the opposite influence of the cited enhancers on the diffusion coeff. and the partition coeff. of the drug. The enhancers increase the resistance of the skin to the penetration of drug mols. (decreasing the diffusion coeff.). Meanwhile, the enhancers facilitate the partitioning process of the drug mols. from the gel to the skin as the apparent partition coeff. increases.
https://bpsa.journals.ekb.eg/article_65901_ff3a53a5c0ac2fbfdebf6cf3e96571dc.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
2001-06-30
24
1
73
82
10.21608/bfsa.2001.65902
65902
Original Article
Preparation and evaluation of sustained release carbamazepine matrix tablets using Eudragit RS 100 and Tragacanth
M. Ahmed
1
A. Aly
2
Departmem of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Industrial Pharmacy, Faculty of Pharmacy, Alisra University, Amman, Jordan
Carbamazepine is a widely prescribed anticonvulsant antiepileptic drug which shows variable absorption and variable bioavailability. It is advisable to prep. it in sustained release dosage form to improve patient compliance and to perform const. blood level with min. side effects. Problems may be encountered with carbamazepine tablets prepd. by wet granulation if the granules are not thoroughly dried before processing. Therefore, the present study deals with the application of direct compression technique to prep. sustained release carbamazepine matrix tablets. Different levels (0 to 25 % wt./wt.) of Eudragit RS 100 and Tragacanth were tested to select the best level of matrix forming material that provides the most release prolonging effect, by direct compression technique using Avicel PH 102 and anhyd. lactose as directly compressible vehicles. Directly compressed matrix tablets of carbamazepine were found to be complied with the USP/NF 23 requirements for the uniformity of wt., diam., and acceptable mech. properties with respect to tensile strength and friability. Examn. of the release characteristics of the drug from the directly compressed tablets as well as the detn. of the release mechanism were carried out. It was found that, as the percentage of the polymer (either Eudragit or Tragacanth) in all formulations increased from 3.125% to 18.75% or 25% wt./wt., the drug release decreased significantly. Involvement of Eudragit RS 100 in the directly compressed matrix tablets gave more sustaining release of carbamazepine than inclusion of Tragacanth in both acidic medium (pH 1.2) and phosphate buffer medium (pH 6.8). This was due to the difference between the physicochem. properties of natural polymer Tragacanth and synthetic polymer Eudragit. Comparatively, the formula of carbamazepine tablet contg. 25 % wt./wt. Tragacanth showed similar release behavior to that of the com. Tegretol tablets. The calcd. exponential release exponents (n values) indicated that release behavior of carbamazepine matrix tablets was anomalous (non-Fickian) diffusion kinetics.
https://bpsa.journals.ekb.eg/article_65902_1d371e0930b156dce27e4b3d01f0036a.pdf
eng
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
2001-06-01
24
1
83
103
10.21608/bfsa.2001.65903
65903
Original Article
MACRO- AND MICROMORPHOLOGICAL STUDY OF THE LEAF, STEM & ROOT OF JUGLANS NIGRA LINN. (BLACK WALNUT) CULTIVATED IN EGYPT
D. Bishay
1
A. Attia
2
S. Youssef
3
I. Khallaf
4
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
The detailed macro- and micromorphological characters of the leaf, stem and root of juglans nigra Linn. (Black Walnut) cultivated in Egypt have been studied in order to find out the diagnostic features which can help in the identification of the plant in both entire and powdered forms.
https://bpsa.journals.ekb.eg/article_65903_ec0ab4f6bbcf6fd7e10ef2a64920756b.pdf