ORIGINAL_ARTICLE
LIPIDS, PIGMENTS AND SAPONINS OF SANSEVIERIA CYLINDRICA, BOJER.
Eleven fatty acids were identified by GLC analysis of the saponified fraction of the lipid content of S. cylindrical, Bojer leaves. A hydrocarbon and b-sitosterol were isolated from the unsaponifiable fraction and were identified by IR and GLC techniques.
The unsaponifiable fraction of the root contained b-carotin. The plant saponins were also isolated and estimated.
https://bpsa.journals.ekb.eg/article_74466_ef728998a8987da80cd4e2c8035a01ab.pdf
1986-06-30
1
10
10.21608/bfsa.1986.74466
S.
Moustafa
1
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt
AUTHOR
H.
Kadry
2
Department of Pharmacognosy, Faculty of Pharmacy, El-Azhar University, Egypt
AUTHOR
M.
El-Olemy
3
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt
AUTHOR
M.
Bisher
4
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt
AUTHOR
ORIGINAL_ARTICLE
ADSORPTION OF ROTOXAMINE TARTRATE BY AVICEL pH 101
The adsorption of rotoxamine tartrate (RT) by avicel pH 101 was studied at a variety of pH values and in the presence of different concentrations of sodium lauryl sulfate (SLS), sodium cholate (SC), PVP 44000 and different electrolytic species.
The results obtained were well described by the Langmuir equation. The limiting adsorptive capacity and the affinity constant were calculated. The data revealed that as the pH value was increased the limiting adsorptive capacity (a value) decreased. The results also revealed that as the concentration of SLS or SC was increased the affinity of the drug to be adsorbed was decreased. The adsorption of RT was found to be dependent on the type of the electrolyte used. It was found that the degree of adsorption decreased as the valence of the basic radicle of the elyctrolyte increased. PVP was found to have a suppression effect on the amount of RT adsorbed by avicel. Interpretation of the results obtained is also offered.
https://bpsa.journals.ekb.eg/article_74470_7739c16ccb048b5149966116d1d4f564.pdf
1986-06-30
11
24
10.21608/bfsa.1986.74470
Sayed
Ismail
sayed.hussien@pharm.aun.edu.eg
1
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut Egypt
AUTHOR
Sohair
El-Shanawany
2
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut Egypt
AUTHOR
ORIGINAL_ARTICLE
FORMULATION AND EVALUATION OF TRIMETHOPRIM-SULFAMETHOXAZOLE SUPPOSITORIES
Suppositories containing a mixture of trimethoprim (80 mg) and sulfamethoxazole (400 mg) per each were prepared using the fusion method. Witepsol H15 with and without 10% Tween 60 as the mixture of PEG 6000, 4000, 1540 (47:33:20) were used as suppository bases. The physice-chemical properties, in-vitro and in-vivo availability were investigated. The amount of drug released showed that Witepsol H15 with 10% Tween 60 gave the highest amount of SMZ and TMP released. Meanwhile, no much difference has been found in case of suppositories made with Witepsol H15 and the mixture of PEG bases. This indicated that the incorporation of Tween 60 in 10% concentration has a great role in enhancing the release properties of both drugs. The bioavailability study has proved the same findings of the in-vitro investigations, as it was found that Witepsol H15 incorporated with surfactant was the most suitable base for the preparation of TMP-SMZ suppositories.
https://bpsa.journals.ekb.eg/article_74471_8f47682581467d7c0bd887c9d2bc2da5.pdf
1986-06-30
25
39
10.21608/bfsa.1986.74471
A.
Abd El-Gawad
1
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
AUTHOR
E.
Ramadan
2
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
AUTHOR
A.
Nouh
3
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
AUTHOR
ORIGINAL_ARTICLE
EFFECT OF COPRECIPITATE FORMATION AND CERTAIN NON-IONIC SURFACTANTS ON CHLORDIAZEPOXIDE RELEASE FROM CAPSULES
The solvent method was employed to prepare coprecipitates with certain carriers and the water-insoluble drug chlordiazepoxide to enhance its dissolution rate. The investigated carrierswere: poly-ethylene glycol 4000 (PEG 4000), polyvinylpyrrolidone 44000 (PVP 44000) and a-cyclodextrin (a-CYC) in ratios 1:1, 1:3 and 1:7 (drug: carrier), respectively.
The dissolution rate of chlordiazepoxide from its prepared coprecipitates using the previously mentioned carriers, especially a-CYC, was found to be higher than that of the drug alone in 0.1N HCl as a dissolution medium.
The effect of certain non-ionic surfactant solutions including Brih 35 and Eumulgin C1000 on the release of chlordiazepoxide from the prepared coprecipitates was also investigated.
It was found that the investigated surfactants in the concentration used (0.1% W/V), produced better drug release than the control, especially when PEG 4000 was used as a carrier.
The mode of interaction taking place between chlordiazepoxide and the investigated carriers was studied by different techniques including UV, IR, chromatography and differential thermal analysis, where a complex formation between chlordiazepoxide and coprecipitating agents was revealed.
https://bpsa.journals.ekb.eg/article_74474_689a01c7004baac605c42a56da66d52d.pdf
1986-06-30
40
59
10.21608/bfsa.1986.74474
A.
Aboutaleb
1
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
Aly
Abdel Rahman
2
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
E.
Samy
3
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
ORIGINAL_ARTICLE
DISSOLUTION BEHAVIOUR OF TOLAZAMIDE IN THE PRESENCE OF CERTAIN NON-IONIC SURFACTANTS
The dissolution rate of tolazamide, on oral hypoglycemic drug, was studied in distilled water as well as solutions of polysorbates and myrjs at 30°C using the beaker method. The surfactant concentration was increased from 0.001 to 0.5% W/V in order to study the effect of the surfactant concentration on the dissolution rate of tolazamide. The relative area under the curve, from0-60 minutes (R.A.U.C.0-60) was used as a parameter to compare the effect of different surfactants, used at the same concentration (0.5% W/V), on the dissolution rate of tolazamide. It was found that the amount of the drug dissolved was significantly dependent on the concentration of each surfactant used as well as the type of the surfactant. The mechanism of the increase in the dissolution rate was also discussed.
https://bpsa.journals.ekb.eg/article_74475_02340ac4c9b58f5bdd56baf7228f19cf.pdf
1986-06-30
60
70
10.21608/bfsa.1986.74475
Sayed
Ismail
sayed.hussien@pharm.aun.edu.eg
1
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
Ali
Abdel Rahman
2
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
ORIGINAL_ARTICLE
FORMULATION OF AZAPROPAZONE SUPPOSITORIES AND EXAMINATION OF ITS EFFECT ON THE GASTROINTESTINAL TRACT OF RABBITS
The rectal absorption of azapropazone, in rabbits, from different suppository formulations was investigated, and compared with its in-vitro release. A comparison between the rectal absorption of the drug and its absorption from capsule was done. The effect of azapropazone on the gastrointestinal tract of rabbits was studied. It was proved that the rectal absorption of the drug is a function of the nature or suppository bases. Of the tested bases, a base consisting of a mixture of PEG 6000, 1540 and 400 (47:33:20) gave the highest in-vitro release, however Witepsol Hl5 produced the highest rectal absorption of the medicament. The availability of azapropazone from the capsules was much better than that from the suppositories. The effect of the orally and rectally administered drug on the duodenal mucosa was deleterious with a marked ulceration. No ulcerative changes could be detected on the rectal mucosa in any of the tested groups of rabbits. On the gastric mucosa, there was a pronounced ulcerative changes in case of oral administration
https://bpsa.journals.ekb.eg/article_74476_817d4940b35a07c0756222a67f779beb.pdf
1986-06-30
71
88
10.21608/bfsa.1986.74476
A.
Nouh
1
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
AUTHOR
E.
Ramadan
2
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
AUTHOR
A.
Abdel-Gawad
3
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
AUTHOR
ORIGINAL_ARTICLE
SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW AZO DYES
The synthesis of some new azo dyes is described. Their structures were confirmed by microanalyses, IR, NMR and MS. The anti-inflammatory and antimicrobial activities of some of them were determined.
https://bpsa.journals.ekb.eg/article_74477_4593e2121ecf9c0d07b004b8bac06869.pdf
1986-06-30
89
104
10.21608/bfsa.1986.74477
A. R.
Ossman
1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
AUTHOR
M.
Ibrahim
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
AUTHOR
ORIGINAL_ARTICLE
SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME NEW 2,4,-(lH, 3H) QUINAZOLINEDIONE DERIVATIVES
Some new (1H, 3H) quinazolinedione derivatives were prepared their structures were confirmed by microanalysis and IR. Some of them were confirmed by NMR and mass spectra, some of these compounds are active as anticonvulsants.
https://bpsa.journals.ekb.eg/article_74478_33a9bafe54b510ecfc797b1018fc433e.pdf
1986-06-30
105
118
10.21608/bfsa.1986.74478
A. R.
Ossman
1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
AUTHOR
A.
Osman
2
Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt
AUTHOR
A.
El-Helby
3
Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt
AUTHOR
ORIGINAL_ARTICLE
KINETICS OF ASPIRIN HYDROLYSIS IN AQUEOUS SOLUTION OF SURFACTANTS I- NON-IONIC SURFACTANTS
The kinetics of aspirin hydrolysis were studied in the presence of different concentrations of polysorbates and at a variety of pH range. The aspirin hydrolysis in the presence of polysorbates followed first-order kinetics and the observed rate constants at different pH values and in the presence of the surface-active aaents were calculated. The surfactant effect ratio (SER) was calculated and found to be decreased as the surfactant concentration was increased. The micellar rate constant, Km , for the drug in the presence of the tested surfactants at a given pH value as well-as the distribution coefficient, K, of aspirin between the micellar and the aqueous phases were estimated. From the results obtained, it could be observed that the Km and K values are markedly influenced by the pH value of the system. The study revealed that the surfactants are not only used to solubilize those poorly water soluble compounds but also to increase their stability in aqueous solutions.
https://bpsa.journals.ekb.eg/article_74479_68b56fee53b192de6486f59e76372e8b.pdf
1986-06-30
119
136
10.21608/bfsa.1986.74479
S.
Ismail
1
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
A.
Simonelli
2
Department of Pharmaceutics, Faculty of Pharmacy, University of Connecticut, USA
AUTHOR
ORIGINAL_ARTICLE
COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS 3- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND CERTAIN PHYSICOCHEMICAL PARAMETERS OF RING SUBSTITUENTS
The color intensity developed from the reaction of twelve phenothiazine drugs with I3 has been correlated using physicochemical substituent like Hammett constant sp, and molecular connectivity 1Xv. Results indicated a predominant role of electronic parameter in determining color intensity. The bulkiness described by 1Xv played a significant role. However, other parameters of the side chain were also prominent. Working up multiple parametric regression can be used as a reliable tool to predict the sensitivity and scope of the colorimetric method for other phenothiazines.
https://bpsa.journals.ekb.eg/article_74480_9c702bc2050effab5063b3e61fc8ba22.pdf
1986-06-30
137
148
10.21608/bfsa.1986.74480
S.
El-Shabouri
1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt
AUTHOR
A.
Youssef
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt
AUTHOR
F.
Mohamed
3
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt
AUTHOR
A-M.
Rageh
4
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt
AUTHOR
ORIGINAL_ARTICLE
PHYTOCHEMICAL STUDIES ON ASTER SQUAMATUS L. PART III: CONSTITUENTS OF THE LEAVES
From the air- dried powdered leaves of Aster squamatus L., we isolated and identified quercetin-3-methyl ether, quercetin-4'-methyl-ether, Kaempferol, quercetin, quercetin-3-O- diarabinoside, quercetin-3-methyl ether-4'-O- dirhamnoside, a saturated hydrocarbon, a- and b- amyrin, mixture of stigmasterol, campesterol, and b-sitosterol, sitosterol-3-0-xyloside, in addition to a triterpene alcohol and a triterpene acetate.
https://bpsa.journals.ekb.eg/article_74481_62fdd956a7b502c1f8400c1c121ed7f8.pdf
1986-06-30
149
163
10.21608/bfsa.1986.74481
H.
Sayed
1
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
S.
Ross
2
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
ORIGINAL_ARTICLE
CHEMICAL CONSTITUENTS AND PRELIMINARY ANTHELMINTIC ACTIVITY OF FICUS PLATYPHYLLA (DEL)
A phytochemical study of Ficus platyphylla Del cultivated in Egypt is presented. A 7-methoxy coymarin (herniarin), two unidentified coumarins, a- and b-amyrin, ceryl alcohol, b-sitosterol, ursolic acid; in addition, chrysoeriol, rutin and unknown flavonoid aglycone were isolated. The organic acids content of the fruits was identified. The amino acids as well as the curdling effect and proteolytic activity of the latex were investigated. The anthelmintic activity of the 40% ethanolic extract of the fruits was studied in-vivo. A pronounced decreae in number of Ascaris worms in relation to the injected embryonated eggs was noticed in treated Fayomi chickens. This effect increases markedly with the increase of the given dose.
https://bpsa.journals.ekb.eg/article_74482_4ec902ade9ad7218f1dbc2f854da6b36.pdf
1986-06-30
164
177
10.21608/bfsa.1986.74482
S.
El-Sayyad
1
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
H.
Sayed
2
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
S.
Mousa
3
Department of Poultry, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
AUTHOR