ORIGINAL_ARTICLE
MACRO- AND MICROMORPHOLOGY OF THE LEAF, STEM, STEM BARK AND FRUIT OF FAIDHERBIA ALBIDA (DEL.) A. CHEV. CULTIVATED IN EGYPT
The trees of Faidherbia albida Del. are indigenous to Africa and considered a prominent feature in the flora of Nile valley and the Eastern Desert. They are known as Apple-ring trees because the pods tend to roll in to a spirals resembling dried apple peal. It is employed traditionally to treat disorders such as fever, diarrhoea, urticaria, vomiting, cough, rheumatism and haemorrhage. To our knowledge, few morphological and microscopical studies were traced concerning the plant1, so this study aims for characterization and identification of this plant in both entire and powdered forms.
https://bpsa.journals.ekb.eg/article_62461_b98bb3ab13fd07328980a8ab0b80d45a.pdf
2018-12-31
1
29
10.21608/bfsa.2018.62461
Marwa
Mohammed
1
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
LEAD_AUTHOR
Ahmed
Ali
2
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
Ezz-eldin
Desoky
3
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
Lourin
Gobraeil
4
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
ORIGINAL_ARTICLE
FORMULATION OF 5-FLUOROURACIL MICROSPONGES AS COLON TARGETED DELIVERY SYSTEM USING 32 FACTORIAL DESIGN
5-Fluorouracil is widely used for treatment of colorectal cancer and is provided as intravenous bolus or infusion because it has erratic oral bioavailability. Diarrhea and myelosuppression are potential and the major side effects of the intravenous administration route. This work was aimed to develop colon-targeted delivery of 5-Fluorouracil microsponges so that, the oral bioavailability enhanced and the side effects could be potentially reduced. Quassi-emulsion solvent diffusion method was used to prepare 5-Fluorouracil microsponges using polyethylene glycol as an emulsifier. Different formulae were prepared with different composition and processing factors. The entrapment efficiency 5-Fluorouracil in these formulae ranged from 17.81 to 78.61%, the particle size of the prepared microsponges ranged from 87 to 229 µm and the % cumulative drug released after 24 hours ranged from 47.7 to 98.58%. The prepared microsponges were subjected to compatibility studies as Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Thus 5-fluorouracil microsponges considered as a promising system for the colon-specific delivery that has potential for future use as an anticancer therapy for colorectal cancer.
https://bpsa.journals.ekb.eg/article_62464_bd92a7d7d6e6e2744b425491924ccccb.pdf
2018-12-31
31
44
10.21608/bfsa.2018.62464
Ahmed
Ali
1
Department of Pharmaceutics, Faculty of Pharmacy, Asyut University, Asyut 71526, Egypt
AUTHOR
Mahmoud
El-Badry
elbadry@aun.edu.eg
2
Department of Pharmaceutics, Faculty of Pharmacy, Asyut University, Asyut 71526, Egypt
AUTHOR
Tahani
Elfaham
3
Department of Pharmaceutics, Faculty of Pharmacy, Asyut University, Asyut 71526, Egypt
LEAD_AUTHOR
ORIGINAL_ARTICLE
NARINGIN PREVENT CISPLATIN-INDUCED NEPHROTOXICITY BY ABROGATION OF OXIDATIVE STRESS AND INFLAMMATION IN RATS
Nephrotoxicity remains one of the most dangerous effect relevant to cisplatin use in chemotherapy. Rat injection with cisplatin in a single dose of 7 mg/kg intraperitoneally resulted in a significant increase in serum level of urea and creatinine. Also, cisplatin caused marked increase in renal content of malondialdehyde (MDA), while depletion in reduced glutathione (GSH). In addition, cisplatin administration notably increased kidney/body weight ratio, renal contents of nitric oxide (NO), tumor necrosis factor alpha(TNF-α) and cyclooxygenase-2 (COX-2) protein level as well as renal myeloperoxidase (MPO) activity. Histopathological examination confirmed the biochemical and molecular results which revealed several pathological alteration in the renal tissues following cisplatin. Oral pretreatment of rats with naringin (NAR) (80 mg/kg) for 14 days before and 7 days after cisplatin injection significantly reduced the pathological level of serum urea and creatinine and restored oxidative stress parameters. In the same manner, the inflammatory markers as well as kidney/body weight ratio show great improvement following the treatment. The histopathological examination confirms fit with the biochemical and molecular results. In conclusion, NAR showed a great protective effect against cisplatin-induced nephrotoxicity in rats via its antioxidant, anti-inflammatory roles.
https://bpsa.journals.ekb.eg/article_62467_c1843fc8d01797198eacf16b6ac2655b.pdf
2018-12-31
45
54
10.21608/bfsa.2018.62467
Abd-Elmoniem
Taha
1
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt
AUTHOR
M.
Khalifa
2
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Egypt
LEAD_AUTHOR
Mohamed
Abd El-Salam
3
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt
AUTHOR
ORIGINAL_ARTICLE
BOTANICAL PROFILING OF GMELINA PHILIPPENSIS CHAM., CULTIVATED IN EGYPT
Gmelina philippensis Cham. Family Lamiaceae, sometimes placed in family Verbenaceae, is one of the ornamental and medicinal plants, known as parrot’s peak, as it produces yellow flowers from a long tube-shaped structure comprised of overlapping bracts. It is a sprawling thorny shrub that was formerly taxonomically classified to family Verbenaceae. It is native to Philippines, Burma and distributed in tropical and subtropical countries. The present investigation attempts to study the pharmacognostical features of the aerial parts (leaves, stems and inflorescence) of Gmelina philippensis Cham. which could be helpful in authentication of the plant and establishing pharmacognostical standard measurements which help in its identification in both entire and powdered forms.
https://bpsa.journals.ekb.eg/article_62468_61bf134101801505649c3f250cd8ebbe.pdf
2018-12-31
55
80
10.21608/bfsa.2018.62468
Hanaa
Sayed
1
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
Amany
Ahmed
2
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
Iman
Khallaf
3
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
AUTHOR
A.
Asem
4
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
LEAD_AUTHOR