Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
10
2
1987
12
31
PHYTOCHEMICAL STUDY OF TABEBUIA PENTAPHYLLA HEMSL CULTIVATED IN EGYPT
1
20
EN
D.
W.
Bishay
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
M.
Abdel-Baky
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S.
A.
Ross
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Z.
Z.
Ibrahim
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1987.74392
<em>Preliminary phytochemical screening of Tabebuia pentaphylla hemsl. Revealed the presence of sterols and/or triterpenes, flavonoids and iridoids. From the hexane extract of the leaves </em><em>a</em><em>-amyrin, </em><em>b</em><em>-sitosterols, betulin, betulinic acid, oleanolic acid and a long chain alcohol were isolated. Whill kaempferol, quercetin, kaempferol-3-O-diaglicoside and quercetin-3-O-diglucoside were isolated from the ethyl acetate extract. Specioside (6-O-coumatyl catalpol) and oleanolic acid were isolated from ethyl acetate extract of the bark. The cytotoxicity tests of some isolated compounds were carried out on cell cultures of p-388 and KB cells. The results obtained showed some positive significances.</em>
https://bpsa.journals.ekb.eg/article_74392.html
https://bpsa.journals.ekb.eg/article_74392_c3c1b471abc07e12285c40a06cb2e0fd.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
10
2
1987
12
31
COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS. 4- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND F, R AND X PARAMETERS OF RING SUBSTITUENTS
21
33
EN
M.
E.
El-Kommos
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt
A.
F.
Youssef
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt
10.21608/bfsa.1987.74393
<em>Colorimetric determination of phenothiazines with NBS in strong sulfuric acid solution has been previously reported (6, 7). Correlation of log </em><em>e</em><em><sub>max</sub></em><em> with </em><em>Â</em><em> and 2</em><em>c</em><em>v parameters of C-2 and N-10 substituents is highly significant only on absence of vulnerable groups at C-2 position. Log </em><em>e</em><em><sub>max</sub></em><em> of four compounds with the same N-10 side chain was correlated with </em><em>Á</em><em> parameters of C-2 substituents irrespective of their vulnerability to the reagents. Correlation equations were used to predict the electronic parameters </em><em>Á</em><em>,</em><em>Â</em><em> and </em><em>s</em><em><sub>p</sub></em><em> of –SO<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> from the spectrophotometric reaction model. </em>
https://bpsa.journals.ekb.eg/article_74393.html
https://bpsa.journals.ekb.eg/article_74393_878cdc23e086d48b2b434418b937bdbc.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
10
2
1987
12
31
SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA
34
46
EN
M.
E.
El-Kommos
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1987.74394
<em>A selective spectrophotometric method is developed for the quantitative determination of levodopa. The proposed method is based on the interaction of levodopa with thiosemicarbazide in an alkaline medium to form a red coloured product. At the maximum absorption of 500 nm, Beer's law is adhered to over the 0-5-8 </em><em>m</em><em>g/ml range. Mglar absorptivity of the coloured product is 2.58 x 10<sup>4</sup>. Job's indicates 1:2 ratio of levodopa to thiosemicarbazide. Resulrs of analysis of larodopa tablets by the proposed method agree well with those of U.S.P.XXI. The method is highly selective since a catecholic function with free adjacent positions is required. </em>
https://bpsa.journals.ekb.eg/article_74394.html
https://bpsa.journals.ekb.eg/article_74394_f36b9d7847de5c66ad98580f45866f90.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
10
2
1987
12
31
ARGENTINE, LUPININE, CYTISINE AND N-ETHYLCYTISINE ALKALOIDS FROM SOPHORA SECUNDIFLORA CULTIVATED IN EGYPT
47
54
EN
A.
M.
Makboul
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
M.
Abdel-Baky
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
D.
W.
Bishay
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1987.74395
<em>The leaves of Sophora secundiflora cultivated in Egypt was found to contain the alkaloids: argentine, lupinine, cytisine and N-ethylcytisine.</em>
https://bpsa.journals.ekb.eg/article_74395.html
https://bpsa.journals.ekb.eg/article_74395_f1965beaea5a08d3367570e74dcf8c8d.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
10
2
1987
12
31
PHYTOCHEMICAL STUDY OF MURRAYA EXOTICA L. (RUTACEAE) I- METHOXYLATED FLAVONOIDS OF THE LEAVES
55
70
EN
D.
W.
Bishay
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S.
M.
El-Sayyad
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M.
A.
Abd El-Hafiz
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
H.
Achenbach
Institut fur Angewandte Chemie, Friedrich-Alexander Universität, Erlangen, West Germany
E.
K.
Desoky
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1987.74396
<em>From the air-dried powdered leaves of Murraya exotica L. (Rutaceae), six methoxylated flavones were isolated and identified as: 3,5,6,7,8,3`,4`,5`,-octamethoxyflavone; 3,5,6,7,3`,4`,5`,-heptamethoxyflavone; 5,6,7,3`,4`,5`,-hexamethoxyflavone; 5,6,7,3`,4`,-pentamethoxyflavone; 3,5,7,3`,4`,5`,-hexamethoxyflavone and 3,5,7,8,3`,4`,5`,-heptamethoxyflavone. </em>
<em>The identification was based on physical, chemical and spectral studies including <sup>1</sup>H-NMR, <sup>13</sup>C-NMR and MS analysis.</em>
<em>The antimicrobial and cytotoxic activities of the isolated compounds were studied. </em>
https://bpsa.journals.ekb.eg/article_74396.html
https://bpsa.journals.ekb.eg/article_74396_cc05767c6fb26a259ed0f3c8d4054538.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
10
2
1987
12
31
SPECTROPHOTOMETRIC DETERMINATION OF SOME HALOGENATED 8-HYDROXYQUINOLINES WITH ZIRCONYL CHLORIDE
71
84
EN
I.
H.
Refaat
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M.
E.
El-Kommos
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
H.
H.
Farag
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
N.
A.
El-Rabat
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1987.74397
<em>A spectrophotometric method is described for the determination of 8-hydroxyquinoline (oxine) and three of its halogenated derivatives: 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol), 5,7-diiodo-8- hydroxyquinoline (iodoquinol) and 7-iodo-8- hydroxyl-5-quinoline sulphonic acid (chiniofon). The method involves the use of zirconyl chloride in methanolic medium to give highly absorbing chelates with </em><em>l</em><em><sub>max</sub></em><em> at 364 nm (oxine), 367 nm (chiniofon), or 389 nm (clioquinol and iodoquinol). The molar ratio of the reaction was established and the characteristic features of the IR spectra of the chelates were discussed. The procedure described was applied successfully to the determination of the named compounds in dosage forms and the results obtained were comparable with official methods.</em>
https://bpsa.journals.ekb.eg/article_74397.html
https://bpsa.journals.ekb.eg/article_74397_b88675fafcabc800f90a32acffe31c65.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
10
2
1987
12
31
SPECTROFLUOROMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF SOME TERTIARY AMINE DRUGS
85
102
EN
I.
H.
Refaat
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M.
E.
El-Kommos
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
H.
H.
Farag
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
N.
A.
El-Rabat
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1987.74398
<em>Seventeen drugs belonging to different pharmacological groupings have been determined either in pure form or in pharmaceutical formulations by spectrophotometry and spectrofluormetry. The method involves the condensation of malonic acid with acetic anhydride under the catalysis of a tertiary amine group in an aliphatic or a heterocyclic system. The product of condensation reaction is highly fluorescent and allows the spectrofluorometric determination of drug containing such groups in the ng/ml ranges (</em><em>l</em><em><sub>ex</sub></em><em>=415nm, </em><em>l</em><em><sub>em</sub></em><em>=455 nm).The product of condensations also coloured and allows the spectrophotometric determination of these tertiary amine drugs (</em><em>l</em><em><sub>max</sub></em><em>=333nm). Results of analyses of pure drugs and their dosage forms by the proposed methods are in good agreement with those of the official B.P. and U.S.P. procedures.</em>
https://bpsa.journals.ekb.eg/article_74398.html
https://bpsa.journals.ekb.eg/article_74398_3ca88af6187bb84886d90c6750da5d3f.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
10
2
1987
12
31
MACRO-AND MICROMORPHOLOGY OF THE STEMS AND LEAVES OF FICUS PLATYPHYLLA (DEL.)
103
122
EN
S.
M.
El-Sayyad
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
H.
M.
Sayed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
A.
Attia
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1987.74399
<em>The macro-and micromorphology of the stems and leaves of Ficus platyphylla (Del.) are presented with the aim of finding their characters by which they could be identified and differentiated, both in the entire and powdered forms.</em>
https://bpsa.journals.ekb.eg/article_74399.html
https://bpsa.journals.ekb.eg/article_74399_755b90633af75b6735a4af2afa3c2813.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
10
2
1987
12
31
DISSOLUTION BEHAVIOUR OF METRONIDAZOLE TABLETS
123
138
EN
E.
A.
Ibrahim
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S.
S.
Tous
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
T.
H.
El-Faham
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M.
A.
Hassan
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1987.74400
<em>The dissolution behavior of metronidazol tablets from three locally manufactured brands on the Egyptian market was studied. Four batches from each brand were collected from the market. The compliance of the tablets collected to the USP XX requirements was evaluated. Some batches from certain brands sis not pass the USP XX requirements for disintegration time, potency and weight variation. The USP XX paddle method was used for the dissolution studies. 0.1 N HCl at 37°C was used as the dissolution medium. Nine tablets from each batch were considered in the dissolution study. The results revealed significant differences among and within the batches of the same brand for the percent metronisazole dissolved after 10, 30 and 105 minutes at p</em><em>£</em><em> 0.1 significance level. Moreover a significant difference was found to exist between different brands. The dissolution rate of drug powder was found to be higher than that of tablets.</em>
<em>Furthermore, the drug powder filled into capsules showed higher dissolution behaviour than tablets and lesser than drug powder. In addition, the bioavailability of the drug powder filled into capsules as well as tablets, was studied. The results revealed that there was a correlation between the in-vitro dissolution rate of the drug and its in-vivo absorption data. </em>
https://bpsa.journals.ekb.eg/article_74400.html
https://bpsa.journals.ekb.eg/article_74400_636f6f70a9cfcf953fddfc22b8117e0e.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
10
2
1987
12
31
EVALUATION OF READILY COMPRESSIBLE EXCIPIENTS USING AN INSTRUMENTED SINGLE PUNCH TABLET MACHINE
139
151
EN
S.
I.
Saleh
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
E.
Abou-Taleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
Stamm
Laboratoire de Pharmacotechnie, Faculte de Pharmacie, B.P.10, 67048 Strasbourg, France
10.21608/bfsa.1987.74401
<em>The compression characteristics of eight different readily compressible excipients were studied using an instrumented single punch tablet machine. These excipients were chosen according to their nature as follows: Lactose for tableting (Merck), Lactose DMV and EMDEX being sugar nature, Starch 1500 and Maltodextrin MD 02 being starch in nature, Avicel pH 101 and Elcema p 100 being cellulose in nature in addition to Emcompress (dicalcium phosphate dihydrate). The application of the instrumented tablet machine offered a good scientific comparison for the compression characteristics of these tablets excipients.</em>
https://bpsa.journals.ekb.eg/article_74401.html
https://bpsa.journals.ekb.eg/article_74401_e178cce1244d1af4cfc8433e9a24337a.pdf