Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
FORMULATION AND STABILITY OF HEPTAMINOL DROPS
251
260
EN
Ali
A.
Kassem
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Mohamed
F.
El-Miligi
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Siham
A.
Ali
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
10.21608/bfsa.1984.89688
<em>Several aqueous solvents were tried for the formulation of Heptaminol base in oral drops. Also, some stabilizing agents were evaluated for their action on the stability of Heptaminol base in the selected solvents. It was observed that distilled water conferred the best stability to Heptaminol base even when compared to market drope. Inclusion of 0.1 percent sodium thiosulphate in the latter solvent seems to be ineffective for further stabilization. In other solvents, the antioxidants tried largely detracted from the stability of Heptaminol base. In addition, 50 percent sorbitol in water was clearly found the worst solvent with regards to Heptaminol stability.</em>
https://bpsa.journals.ekb.eg/article_89688.html
https://bpsa.journals.ekb.eg/article_89688_830e992c94bc3f22546b567105260ef3.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
FORMULATION AND STABILITY OF HEPTAMINOL INJECTABLE SOLUTION
261
271
EN
A.
A.
Kassem
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
M.
F.
El-Miligi
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
S.
A.
Ali
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
10.21608/bfsa.1984.89691
<em>The present work consists of a study of formulated aqueous injectable solutions of Heptaminol hydrochloride with respect to their physical and chemical stability as such, under different sterilization conditions, in presence, and in absence of antioxidants and bactericides. It was concluded that chlorocresol was incompatible with Heptaminol hydrochloride giving a pink colour. Also, inclusion of an antioxidant improved the shelf-life of Heptaminol injection. Sodium thiosulphate was regarded the first choice among the stabilizers tested. In addition, it was proved that different heat-sterilization techniques adopted variably influenced the medicament stability depending upon the particular antioxidant in the formula. Market injections were also tested and their stability was found to occupy the first place.</em>
https://bpsa.journals.ekb.eg/article_89691.html
https://bpsa.journals.ekb.eg/article_89691_9d751cd624ce5b4ca199f76bfaabf7d5.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
FORMULATION AND STABILITY OF HEPTAMINOL SUPPOSITORIES PART I: Comparative Stability of Heptaminol Base and Heptaminol Hydrochloride
272
275
EN
Ali
A.
Kassem
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Mohamed
F.
El-Miligi
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Siham
A.
Ali
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
10.21608/bfsa.1984.89695
<em>The chemical stability of Heptaminol Base and of Heptaminol hydrochloride was determined after shelf-life storage in an aqueous solution at room temperature. Under these conditions, the Base was found about 10.54 times more stable than the hydrochloride.</em>
https://bpsa.journals.ekb.eg/article_89695.html
https://bpsa.journals.ekb.eg/article_89695_c1b258a3d4e6d5383c905b1ecce0119f.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
FORMULATION AND STABILITY OF HEPTAMINOL SUPPOSITORIES PART II: Formulation and Characterization of Heptaminol Suppositories
276
287
EN
Ali
A.
Kassem
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Mohamed
F.
El-Miligi
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Siham
A.
Ali
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
10.21608/bfsa.1984.89698
<em>Heptaminol base was formulated in four different suppository bases. The prepared suppositories were subjected to the usual quality-control tests, both when fresh and after shelf-storage for one year. The results of physical examination were so variable that a sharp conclusion to a preferred formula was not possible. However, studies of medicament dissolution revealed that quick and full-dose release of heptaminol was achieved from glycerogelatin-based suppositories. On the other hand, suppositories based with polyethylene glycols have shown a prolonged heptaminol dissolution rates.</em>
https://bpsa.journals.ekb.eg/article_89698.html
https://bpsa.journals.ekb.eg/article_89698_4d97fd4b23f5049821701e44700b2294.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
FORMULATION AND STABILITY OF HEPTAMINOL SUPPOSITORIES PART III: Chemical Stability of Heptaminol Suppositories
288
294
EN
Ali
A.
Kassem
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Mohamed
F.
El-Miligi
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Siham
A.
Ali
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
10.21608/bfsa.1984.89702
<em>The chemical stability of Heptaminol base in four different suppository bases was investigated in absence and presence of several stabilizers. The stability was found decreasing in the order of: Glycerogelatin, Cacao-Butter, Witepsol-E-75, and then Polyethylene-Glycols. Butylated hydroxyanisol (BHA) was the best stabilizer in the two fatty-based formulae, while tocopherol succinate was the worst. In the water-soluble bases, sodium thiosulphate was the best stabilizer, while the mixture of sodium formaldehyde sulfoxylate (SFS) with sodium edentate was the worst.</em>
https://bpsa.journals.ekb.eg/article_89702.html
https://bpsa.journals.ekb.eg/article_89702_00826ee914610ed17291848f22109ce0.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
ENHANCED DISSOLUTION RATE OF IBUPROFEN USING SURFACTANTS AND WATER SOLUBLE CARRIERS
295
304
EN
M.
El-Shaboury
Department of Pharmaceutics, Facutly of Pharmacy, Mansoura University, Mansoura, Egypt
A.
T.
Nouh
Department of Pharmaceutics, Facutly of Pharmacy, Mansoura University, Mansoura, Egypt
A.
H.
Abd El-Gawad
Department of Pharmaceutics, Facutly of Pharmacy, Mansoura University, Mansoura, Egypt
10.21608/bfsa.1984.89707
<em>The influence of some non-ionic surfactants as well as polyethylene glycol 6000 and dextrose as water soluble carrier, on the dissolution of poorly soluble drug, ibuprofen, was studied. Surfactants produced better drug release than the polyethylene glycol and dextrose with the drug carrier ratio studied. TLC and IR studied ruled out any interaction between the drug and any of the additives used. In addition, the bulkness of the drug was not affected by the amount of surfactants added, as being found with dextrose and polyethylene glycol 6000.</em>
https://bpsa.journals.ekb.eg/article_89707.html
https://bpsa.journals.ekb.eg/article_89707_76fe44f42b34a4f07cec6ad34a88575b.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
MACRO AND MICROMORPHOLOGY OF PANCRATIUM SICKENBERGI ASCH. ET SCHWEINF. EX BOISS. GROWING IN EGYPT PART 2: The Inflorescence
305
321
EN
A.
A.
Ali
Department of Phamracognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M.
K.
Mesbah
Department of Phamracognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M.
H.
Mohamed
Department of Phamracognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1984.89709
<em>In a previous paper</em> <em>the macro and micromorphology of the roots, bulbs and foliage Leaves of Pancratium sickenbergi Asch. Et Schweinf. Ex Boiss. was presented. The present work deals with the micro and macroamorphology of the inflorescence of the same plant.</em>
https://bpsa.journals.ekb.eg/article_89709.html
https://bpsa.journals.ekb.eg/article_89709_afa3dbe000e26bc68ecc1c571e165696.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
SOLUBILIZATION AND STABILITY OF PYRIDINE-3-CARBOXALDHYDE THIOSEMICARBAZONE BY DIFFERENT MICELLAR FORMING MATERIALS
322
337
EN
A.
P.
Simonelli
School of Pharmacy, University of Connecticut, STORRS, CT 06268, U.S.A
A.
E.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
A.
Abdel-Rahman
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1984.89713
<em>Pyridine-3-Carboxaldhyde thiosemicarbazone (P3CTZ) used in cancer therapy was solubilized by anionic cationic and nonionic surfactant solutions of pH </em>5,6,7,8 <em>and ionic strength (u) of 0.2 at </em>47. <em>So sodium dodecyl sulphate (SDS), cetyl trimethyl ammonium bromide (CTAB) and Brij </em>35 <em>were chosen to represent the last three classes respectively. It was found that SDS has the highest solubilizing efficiency toward P3CTZ followed by Brij </em>35 <em>and CTAB respectively at all pH values studied. .</em>
<em>The stability of P3CTZ was studied in different concentrations of surfactants at pH values of </em>5,6,<em>7 and 8 and u of 0.2.</em>
<em>It was found that the longest t½ observed was in Brij </em>35 <em>solution of pH </em>5 <em>at 47° (nearly t½ equal one year). The shortest t½ was found in CTAB solutions. It was found also that the partition coefficient from solubility slightly higher than that obtained from stability measurements.</em>
<em>It was concluded that the stability of P3CTZ is greater relatively at higher pH values, than at lower pH values as reported by other workers.</em>
https://bpsa.journals.ekb.eg/article_89713.html
https://bpsa.journals.ekb.eg/article_89713_fcc4a3caf4a80be5946465a1b854c427.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
DETERMINATION OF IRIDOIDS, FLAVONOIDS AND MANNITOL IN JASMINS GROWING IN EGYPT
338
350
EN
S.
A.
Ross
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M.
A.
Abdel-Hafiz
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
N.
E.
El-Keltawi
Department of Horticulture, Faculty of Agriculture, Assiut University, Assiut, Egypt
10.21608/bfsa.1984.89861
<em>A qualitative and quantitative study on the distribution of iridoids, flavonoids and mannitol in </em>5 <em>of Jasmins has been carried out. The over ground parts of the plants under investigation are free from flavonoidal aglycones. They contain flavonol glycosides but no flavones. Kaempferol glycosides are mainly restricted in J. azoricum, L. On the other hand, quercetin-3-O-dirhamnoglucoside </em>is <em>present mainly in the </em>2 <em>varieties of J.sambac, Ait. and absent in J. azoricum, L. Iridoids (Jasminin and azoricin), flavonol glycosides (rutin and quercetrin) and mannitol are present in all samples in a significant concentrations and can be considered </em>as <em>finger prints for them.</em>
https://bpsa.journals.ekb.eg/article_89861.html
https://bpsa.journals.ekb.eg/article_89861_c3aa26c887155bbbde8bbbd27abd1496.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
STUDY OF ALKALOIDS OF PANCERATIUM MARITIMUM L. GROWING IN EGYPT
351
362
EN
A.
A.
Ali
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M.
K.
Mesbah
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M.
H.
Mohamed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1984.89865
<em>The main alkaloids, viz., tazettine, pancracine, lycorine and hippadine were isolated in pure crystalline</em> forms <em>and their identity was confirmed through determining their physical, chemical and spectral analysis. In addition, four bases were isolated in too small quantities for identification, their picrate derivatives were prepared and investigated.</em>
<em>Identification of micro-quantities of the isolated compounds by microchemical techniques is described.</em>
https://bpsa.journals.ekb.eg/article_89865.html
https://bpsa.journals.ekb.eg/article_89865_54862db6d1edeb9a6a76709ccd979d67.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
SOLUBILIZATION AND STABILITY OF CLONAZEPAM BY DIFFERENT CLASSES OF SURFACTANTS
363
379
EN
A.
P.
Simonelli
School of Pharmacy, University of Connecticut, STORRS, CT 06268, U.S.A.
A.
E.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
A.
Abdel-Rahman
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1984.89866
<em>Clonazepam a 1,4-benzodiazepine derivative acting </em>as <em>tranquillizer and hypnotic is practically water insoluble. It was solubilized by three different classes of surfactant solutions at pH </em>5,6,7 <em>and </em>8 <em>and of ionic strength (U) of 0.2. Sodium dodecyl sulphate (SDS), cetyl trimethyl ammonium bromide (CTAB) and Brij </em>35 <em>were chosen for this study, which was carried out at</em> 25, 35 <em>and 65°. Neither the presence of the surfactant solutions in the concentrations used nor the presence of the degradation product (s) of clonazepam interfer in the spectrophotometric assay of the drug. At all the temperatures, and pH values investigated it was found that SDS solutions is the most efficient solubilizers for clonazepam followed by CTAB and Brij </em>35 <em>solution respectively.</em>
<em>Accelerated stability study of clonazepam was carried out in different concentrations of the</em> last <em>mentioned solutions at 65°. The half life (t½) of clonazepam was calculated in the prepared solutions and the longest t½ for clonazepam is in SDS solution of pH </em>6.
<em>The distribution coefficient (k<sub>m</sub>) of clonazepam in the studied solutions was calculated from solubility and compared with the partition coefficient obtained from stability data (P<sup>@</sup>).</em>
https://bpsa.journals.ekb.eg/article_89866.html
https://bpsa.journals.ekb.eg/article_89866_c7caa8d2949fbb91f24a7492c13bfa13.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
STUDY OF THE LIPID AND FLAVONOID CONTENTS OF ASTRAGALUS CREMOPHILOS BOISS. GROWING IN EGYPT
380
388
EN
M
A.
Makboul
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M.
A.
El-Shanawany
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
M.
Abdel-Baky
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1984.89868
<em>From pet. ether extract of Astragalus cremophilos Boiss. B-sitosterot and ceryl alcohol were isolated from the unsaponifiable fraction as well as fatty acids were studied by GLC. In addition, seven flavonoidal compounds were isolated: Kaempferol, quercetin, Luteolin, Luteolin-7-O-glucoside, kaempferol-3-O-glucoside (astragalin), apigenin-7-O-glucoside, quercetin-3-O-rhamnoside, (quercetrin) and rutin from the methanolic extract of the plant.</em>
https://bpsa.journals.ekb.eg/article_89868.html
https://bpsa.journals.ekb.eg/article_89868_e645be8750863e7ff95f3414764aed81.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
PHYTOCHEMICAL STUDIES ON ASTER SQUAMATUS L. PART II: Sesquiterpene Lactones, Triterpenes and Sterols Present in the Flowers
389
397
EN
S.
A.
Ross
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
H.
M.
Sayed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S.
M.
El-Sayyad
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1984.89869
<em>Two sesquiterpene lactones santamarin and reynosin were isolated </em>from <em>the flowers of A. squamatus L. In addition </em><em>a</em><em>-and β-amyrin, ursolic acid, a mixture of stigmasterol, campesterol and </em><em>b</em><em>-sitosterol and an unidentified sesquiterpene lactone were isolated in pure form.</em>
https://bpsa.journals.ekb.eg/article_89869.html
https://bpsa.journals.ekb.eg/article_89869_feee371b7ef3ffcc919c45c00dba4913.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
EFFECT OF CERTAIN ADDITIVES ON THE DIFFUSION CHARACTERISTICS OF ASPIRIN, SALICYLAMIDE AND PHENACETIN THROUGH A CELLOPHANE MEMBRANE II. Effect of Aliphatic Acids and Polyethylene Glycol
398
417
EN
F.
S.
Habib
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
H.
A.
El-Sourady
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S.
E.
Mohamed
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.1984.89871
<em>A study has been carried out showing the effect of succinic, citric and tartaric acids, polyethylene glycols 1500, 2000, 4000 and 6000 on the diffusion rate of aspirin, salicylamide and phenacetin through a standard cellophane membrane. It was found that </em>2% <em>w/v succinic acid was the most effective concentration of acid that increased the diffusion rate of aspirin. The incorporation of </em>3% <em>w/v PEG 2000</em> or <em>6000 slightly increased aspirin diffusion rate. The effect of the previously mentioned aliphatic acid, urea and PEG 4000 </em>or <em>6000 in the form of either solid dispersions</em> or <em>physical mixtures with the drug was also studied. It was found that succinic acid in all its tried concentrations increased the diffusion rate of aspirin.</em>
<em>Salicylamide diffusion rate slightly increased in presence of </em>3% <em>w/v succinic acid, </em>2 <em>and </em>3% <em>w/v citric acid and </em>3% <em>w/v tartaric acid. Salicylamidesuccinic acid solid dispersion slightly increased the diffusion rate of the drug while the other tested drug-carrier solid dispersions of physical mixtures retarded the diffusion rate of salicylamide.</em>
<em>3% w/v of each aliphatic acid tested and PEG 6000 increased the diffusion rate of phenacetin. The other tested concentrations of PEG(s) produced insignificant effect on the diffusion rate of the drug. Phenacetin-urea, PEG 4000 </em>or <em>6000 solid dispersions markedly increased the diffusion rate of phenacetin.</em>
https://bpsa.journals.ekb.eg/article_89871.html
https://bpsa.journals.ekb.eg/article_89871_4a1cbf2f0233a864481de280d7c81c6e.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
VEHICLE INFLUENCE ON OCULAR DISPOSITION OF CHLORTETRACYCLINE HYDROCHLORIDE AND CHLORAMPHENICOL IN THE ALBINO RABBIT
418
429
EN
M.
A.
Attia
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut , Egypt
H.
A.
El-Sourady
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut , Egypt
S.
M.
El-Shanawany
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut , Egypt
10.21608/bfsa.1984.89872
<em>The effect of four bases on the ocular disposition of chloramphenicol and chlortetracycline hydrochloride in the albino rabbits was investigated. It was found that the highest concentration of chlortetracycline hydrochloride in conjunctiva and cornea obtained from absorption base (A) and emulsion base (C). The absorption base (B) and emulsion base (C) were the only bases that can penetrate through the cornea into aqueous humor and irisciliary body. The emulsion base (D) give the highest chloramphenicol concentration in the conjunctiva in comparison with the other bases studied. Chloramphenicol appeared to be rapid uptake from all formulations and distributed across the cornea to the anterior chamber. Chloramphenicol uptake by conjunctiva from two emulsion bases </em>(C <em>and D) was more than from the other two absorption bases (A&B).</em>
https://bpsa.journals.ekb.eg/article_89872.html
https://bpsa.journals.ekb.eg/article_89872_39b1df48aab533c76025be8925a60d06.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
WITHANOLIDES OF WITHANIA SOMNIFERA L. DUNAL GROWING WILD IN EGYPT
430
443
EN
M.
M.
El-Olemy
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt
H.
A.
Kadry
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
10.21608/bfsa.1984.89873
<em>Three Withanolides (Substances A,B, and C) were isolated from the alcoholic extract of the Egyptian Withania somnifera wild plants. Substance A and substance C were identified by IR, NMR and Mass spectral data. Substance A appears to be a configurational isomer of Withanolide E and substance C </em>is <em>4-hydroxy derivative of substance A. Substance A is identified as 14,17,20-trihydroxy-5B,6B-epoxy-1-oxo-Witha-2,24-dienolide (I) and substance C as 4,14,17,20-tetrahydroxy-5B, 6B-epoxy-1-oxo-witha-2,24-dienolide(II).</em>
<em>This is the first report of isolation and characterization of substance C from Withania somnifera or the genus Withania. Substance B would be the subject of a further report.</em>
https://bpsa.journals.ekb.eg/article_89873.html
https://bpsa.journals.ekb.eg/article_89873_f0e9a34b4d5ba9891e9e395f0572447f.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
7
2
1984
12
31
WITHANOLIDES OF EGYPTIAN WITHANIA SOMNIFERA L. DUNAL PART II: 20, 28-Dihydroxy-l-oxo-witha-2,5,8(14), 24-tetraenolide
444
449
EN
M.
M.
El-Olemy
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt
H.
A.
Kadry
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
10.21608/bfsa.1984.89874
<em>The isolation of the title compound was reported in a previous publication. It is now characterized by NMR and mass spectral data as 20, 28-dihydroxy-l-oxo-witha-2,5,8 </em>(14), 24-<em>tetraenolide. This confirms the predominant character of chemo type III in the Egyptian wild plant.</em>
https://bpsa.journals.ekb.eg/article_89874.html
https://bpsa.journals.ekb.eg/article_89874_c0ad345b5dc15d4edb474664ae784067.pdf