Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
SIMULTANEOUS HPLC-UV QUANTIFICATION OF DILTIAZEM AND N-DEMETHYLDILTIAZEM IN HUMAN PLASMA
1
8
EN
S.
S.
Hasan
University College of Pharmacy, Punjab University, Allama Iqbal
Campus, Lahore-54000, Pakistan
Nisar
ur
Rahman
Department of Pharmacy, Islamia University Bahawalpur, Pakistan
Khalid
Hussain
University College of Pharmacy, Punjab University, Allama Iqbal
Campus, Lahore-54000, Pakistan
S.
Atif
Raza
University College of Pharmacy, Punjab University, Allama Iqbal
Campus, Lahore-54000, Pakistan
10.21608/bfsa.2006.64822
A simple and sensitive reversed phase high-performance liquid<br />chromatographic method was developed for simultaneous<br />quantification of diltiazem HCl and its major metabolite Ndemethyldiltiazem<br />in human plasma. The method involves one step<br />solvent extraction of diltiazem, N-demethyldiltiazem and the internal standard, verapamil with n-hexane and diethyl ether<br />(50:50 v/v). The mobile phase comprised 0.1 M ammonium<br />dihydrogen phosphate-acetonitrile (62:38 v/v) and triethylamine<br />(0.08%) was added before the pH was adjusted to 5.9 with 85%<br />phosphoric acid. Analysis was run at a flow rate of 1.0 ml/min at a<br />detection wavelength of 238 nm. The completion time for assay was<br />not more than 10 minutes and lower limit of quantification was 5<br />ng/ml. The calibration curve for diltiazem and its metabolite was<br />linear over a concentration range of 5-200 ng/ml and average<br />recovery was about 90%. The coefficient of variation and percent<br />error values of the assay method within and between days were all<br />less than 10%.
https://bpsa.journals.ekb.eg/article_64822.html
https://bpsa.journals.ekb.eg/article_64822_6016babf2bbc3f7ac5a5934752fa4bf6.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
PHENOLICS OF CYPERUS ALOPECUROIDES ROTTB. INFLORESCENCES AND THEIR BIOLOGICAL ACTIVITIES
9
32
EN
H.
M.
Sayed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut
University, Assiut, Egypt
M.
H.
Mohamed
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar
University, Assiut, Egypt
S.
F.
Farag
Department of Pharmacognosy, Faculty of Pharmacy, Assiut
University, Assiut, Egypt
G.
A.
Mohamed
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar
University, Assiut, Egypt
R.
Ebel
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-
Heine-University, Universitätsstraße 1, 40225 Düsseldorf, Germany
O.
R. M.
Omobuwajo
Department of Pharmacognosy, Faculty of Pharmacy, Obafemi
Awolowo University, Ile-Ife, Nigeria
P.
Proksch
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-
Heine-University, Universitätsstraße 1, 40225 Düsseldorf, Germany
10.21608/bfsa.2006.64823
Sixteen phenolic compounds, scopoletin (1), isoliquiritigenin 4-<br />methyl ether (2), luteolin 5,3-dimethyl ether (3), luteolin 7,3-<br />dimethyl ether (4), aureusidin 4-methyl ether (5), apigenin (6),<br />luteolin (7), trans-ferulic acid (8), luteolin 4-O- -D-glucopyranoside<br />(9), luteolin 7-O- -D-glucopyranoside (10), quercetin<br />3-O- -D-glucopyranoside (11), apigenin 7-O-neohesperidoside<br />(12), kaempferol 3-O-rutinoside (13), quercetin 3-O-rutinoside<br />(14), kaempferol 3-O-[2-O-D-xylopyranosyl-6-O--L-rhamnopyranosyl]-<br /> -D-glucopyranoside (15) and kaempferol 3-O-[2-OD-<br />glucopyranosyl-6-O--L-rhamnopyranosyl]- -D-glucopyranoside<br />(16) were isolated from the methanolic extract of the<br />inflorescences of Cyperus alopecuroides Rottb. for the first time.<br />Their structures have been established on the basis of physical,<br />chemical and spectroscopic methods in addition to comparison<br />with literature data and/or authentic samples. The antioxidant and<br />cytotoxic activities in addition to -amylase inhibitory activity of<br />the isolated compounds have been studied.
https://bpsa.journals.ekb.eg/article_64823.html
https://bpsa.journals.ekb.eg/article_64823_69f99f95923e7cc4c2171b3b215f9b70.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
SPECTROPHOTOMETRIC AND SPECTROFLUORIMETRIC DETERMINATION OF CERTAIN DIURETICS IN PURE FORMS AND IN THEIR PHARMACEUTICAL FORMULATIONS
33
58
EN
Michael
E.
El-Kommos
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Ahmad
A.
Ahmad
Department of Organic Chemistry, Faculty of Science, Minia University, Minia, Egypt
Hesham
Salem
Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
Mahmoud
A.
Omar
Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
10.21608/bfsa.2006.64874
Three Simple and selective spectrophotometric and spectrofluorimetric methods were developed for the quantitative determination of certain diuretics (bendroflumethiazide, benzthiazide, chlorthalidone, clopamide, hydrochlorothiazide, hydroflumethiazide, indapamide and xipamide) in pure forms as well as in their pharmaceutical formulations through their hydroxamate formation and subsequent complexation with iron (method I), reaction with potassium ferricyanide (method II) and reaction with 4-chloro-7-nitrobenzofurazan (method III). The conditions for different reactions were studied and optimized. The methods have been validated and successfully applied to the analysis of bulk drugs and their tablets with good recoveries ranging from 97.93 (±1.46) to 100.6 (±1.75) for method I, 98.49 (±1.43) to 99.86 (±0.87) for method II, and 98.98 (±1.11) to 99.90 (±0.86) for method III. No interference was observed from common pharmaceutical adjuvants. The results obtained compare well with those of reported methods.
https://bpsa.journals.ekb.eg/article_64874.html
https://bpsa.journals.ekb.eg/article_64874_d622cff68a2a0e01437514afd9fb72c6.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
ISOLATION OF AEROMONAS SPECIES FROM DIARRHEAL PATIENTS IN ISMAILIA GOVERNORATE
59
65
EN
Samar
M.
Mansour
Department of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
Salah
M.
Abdalla
Department of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
Mohamed
Farid A. F.
Ali
Department of Microbiology and Immunology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
mohamedattiashafie@pharm.aun.edu.eg
Alaa
A.
Zeitoun
Department of Pediatrics, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
10.21608/bfsa.2006.65180
In order to know the prevalence of Aeromonas species as a causative agent of diarrhea in Ismailia, Three hundreds and fifty stool samples and rectal swabs were collected from infants and children under the age of 5 years visiting El Kilo11Clinic suffering from acute diarrhea in the period from May 2004 to September 2004. A stool samples were collected from control group of fifty healthy infants and children of matched age and sex. It was found that 29 diarrheal samples were positive for Aeromonas species with prevalence of 8.28%. None of control samples were positive for Aeromonas. In most cases it was found that the infection is water or food borne. Aeromonas strains show high degree of antibiotic susceptibility.
https://bpsa.journals.ekb.eg/article_65180.html
https://bpsa.journals.ekb.eg/article_65180_41aa34d977748cb6e1dd5dc20f63b519.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
EFFECT OF PENETRATION ENHANCERS ON THE PERMEABILITY OF KETOCONAZOLE GELS THROUGH RABBIT SKIN
67
77
EN
A.
H.
Abd-ElGawad
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
F.
M.
Sakr
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
Th.
M.
Borg
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
I.
I.
Abu Hashim
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
10.21608/bfsa.2006.65183
The influence of several penetration enhancers on the percutaneous penetration of ketoconazole (KC) from hydroxypropylmethyl cellulose (HPMC), sodium carboxymethyl cellulose (NaCMC) and carbopol 934 gel formulations was investigated. Skin permeation studies were performed using Franztype diffusion cells and full-thickness abdominal rabbit skin. Various types of compounds such as oleic acid (OA), menthol (M) and isopropyl myristate (IPM) in various concentrations were employed as penetration enhancers. The steady-state flux, permeability coefficients, and enhancement ratios ER flux of KC for each formulation were calculated. The results showed that the skin permeability of KC from gels tested was significantly increased (P< 0.05) by 10% w/w OA, 5% w/w M and 5% w/w IPM. ER flux of KC gels containing 10% OA were 19.5, 16.4 & 11.9 for NaCMC, HPMC & carbopol gel respectively. ERflux of 5% w/w M were 13.5, 13.3 & 10.9 for HPMC, NaCMC & carbopol gel respectively. About 11 fold increase in the ERflux at 5% w/w IPM for all gels. Kinetic analysis of the data indicated that the permeation of (KC) from different gel formulations obeyed Higuchi-diffusion model. In conclusion, OA, M & IPM could be considered as penetration enhancers for KC topical formulations.
https://bpsa.journals.ekb.eg/article_65183.html
https://bpsa.journals.ekb.eg/article_65183_61cb32e4b3bc3141b3ecaabed6dc1f3d.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
NOVEL APPROACH FOR DETERMINATION OF BINDING CONSTANT AND THERMODYNAMIC ACTIVITY OF LIPOPHILIC DRUGS IN INCLUSION COMPLEXES
79
94
EN
Dalia
S.
Shaker
Department of Pharmaceutics, Helwan University, Cairo, Egypt
10.21608/bfsa.2006.65184
In light of prediction of extent of drug molecules that cross biological membranes in drug-complex system, there is a need to re-evaluate the old concept of measuring the binding constant of complexation (Kc) and consequently the drug thermodynamic activity (AT) through octanol-water partition experiment or solubility technique at saturation condition. This study examined the feasibility of the silicone polymer uptake method for determination of AT of corticosterone (CS)-as a model lipophilic drug-in hydroxypropyl beta cyclodextrin (HP CD). Commercial medical grade silicone rubber sheets were used first in the study then replaced by prepared silicone discs to ensure the validity of CS partition data obtained in silicone/phosphate buffered saline (PBS) system in absence and presence of HP CD. In cases of saturation and unsaturation with trace level radioactive corticosterone (3H-CS), the Kc was measured. It was the same at saturation as well as lower drug concentration, and in correlation with that measured by solubility technique at saturation. However, the Kc measured by silicone method deviated from that obtained from octanol/ phosphate buffered saline partition experiment due to possible interaction between HP CD as a complexing agent with lipophilic cavity and the organic phase (octanol). The measured AT values were in agreement with those determined by octanol and solubility methods. This study has clearly shown the validity of the silicone polymer uptake method for the direct determination of CS thermodynamic activity in CS/ HP CD inclusion complex
https://bpsa.journals.ekb.eg/article_65184.html
https://bpsa.journals.ekb.eg/article_65184_98bc119b2e045d286a7e8cea2c29bf09.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
THE EFFECT OF BINDERS ON THE BIOAVAILABILITY OF OFLOXACIN TABLETS IN HUMAN VOLUNTEERS
95
109
EN
Naveed
Akhtar
Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Pakistan
Muhammad
Shoaib
Khan
Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Pakistan
Mahmood
Ahmad
Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Pakistan
Gulzeb
Aziz
Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Pakistan
Mohammad
Aleem
Department of Statistics, Faculty of Science, The Islamia University of Bahawalpur, Pakistan
10.21608/bfsa.2006.65185
The bioavailability of ofloxacin, a fluoroquinolone widely used in the treatment of bacterial infection varies different with different binders used in the formulation of tablets due to different binding properties and variable release characteristics. In this study, two formulations of ofloxacin were prepared. The only difference between them was of binder. The two binders used were gelatin and starch. In-vitro and in-vivo evaluation of tablets was performed. Eight healthy human volunteers were selected for this study, and were divided into two groups each consisting of 4 volunteers. First group was given formulation 1 with gelatin as binder. Each volunteer received 200 mg ofloxacin tablet. Volunteers of the second group were given formulation 2 with starch as binder. After one week wash out period, volunteers of the first group received formulation 2 and volunteers of second group received formulation 1. Blood samples were collected at different time intervals. The drug concentrations in plasma were assayed by High Performance Liquid Chromatography. Pharmacokinetic parameters of formulation 1 were Cmax 1.4412 1.8367 µg/ml, tmax was 1.00 ± 0.00 hours, AUC 8.6804 ± 0.8346 µg.h/ml, AUMC 43.017 ± 0.2893 µg.h2/ml, MRT 4.8869±1.3587 hours, Ke 0.2067 ± 6.9207, T½ 3.3886 ± 1.6321 hours, Vd 113.826±0.2983 L/Kg, Vss 4.833 ± 0.9138 L/Kg, Cl 23.595 ± 0.5070 ml/h/Kg. For Formulation 2 these values were 1.515 1.5898 µg/ml, 0.5 ± 0.00 hours, 9.0317 ± 0.8805 µg.h/ml, 35.4486±0.3337 µg.h2/ml, 3.8798 ±1.4668 hours, 0.2606 ±6.0291, 2.68 ± 1.76 hours, 86.609 ±0.3354 L/Kg, 5.94 ±0.84L/Kg, 22.580 ±0.5333 ml/h/Kg respectively. Statistical analysis was performed and it was found that the formulation 1 (formulated with gelatin) released the drug slightly greater than the formulation 2 within two hours after its administration. There was highly significant difference between mean residence time, elimination rate constant, half life and volume of distribution between both of the formulations. Therefore, formulation 2 has greater bioavailability than the formulation 1. Thus it can be concluded that the binder can affect the bioavailability and pharmacokinetic parameters of a drug.
https://bpsa.journals.ekb.eg/article_65185.html
https://bpsa.journals.ekb.eg/article_65185_dda7ccbed1bbae1d0a58ea2fb19511ed.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
INTERACTION OF TIARAMIDE HYDROCHLORIDE WITH AMBERLITE RESINS: CHARACTERIZATION OF THE INTERACTION AND MODULATION OF THE RELEASE THROUGH MICROENCAPSULATION OF THE PREPARED RESINATES
111
126
EN
M.
Fathy
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University 71526, Assiut, Egypt
10.21608/bfsa.2006.65186
Tiaramide HCl (TAM), a basic NSAID, has high water solubility and short biological half life. The study was undertaken to prolong TAM's activity. TAM resinates were prepared by a batch process and using two resins, namely Amberlite IRP-69 (RI) and Amberlite MB-1 (RII). The resinates (RI/TAM & RII/TAM) were examined by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), infrared (IR) spectrometry and scanning electron microscopy (SEM). A modified emulsion solvent evaporation method was used to produce TAM-resinates coated with cellulose acetate butyrate (CAB) for more drug retardation. The microcapsules were examined using SEM. The results from DSC and XRD showed that the molecular state of the drug in the resinates changed to become amorphous instead of its original crystalline form. The IR spectroscopy revealed the presence of an interaction between the drug and resin. The dissolution behavior for the resinates in 0.1 N HCl or phosphate buffer (pH 7.4) was compared. TAM release was affected by the dissolution medium and resin type and was slower than that from drug powder or physical mixture. TAM release from microcapsules was slower than the uncoated resinates. Additionally, the anti-inflammatory activity, using carrageenan–induced rat hind paw edema, displayed prolonged pattern in comparison with uncoated resinate or free drug
https://bpsa.journals.ekb.eg/article_65186.html
https://bpsa.journals.ekb.eg/article_65186_edc9ff2ed8b55bd5903890db0707dd27.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
NOVEL 1,2,4-TRIAZOLE-3-MERCAPTOACETIC ACID DERIVATIVES AS POTENTIAL ANTIMYCOBACTERIAL AND ANTIMICROBIAL AGENTS
127
136
EN
Nawal
A.
El-Koussi
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
Hamdy
M.
Abdel-Rahman
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
10.21608/bfsa.2006.65187
Novel Schiff bases of 4-methyl-1,2,4-triazole-3-mercaptoacetic acid hydrazide were synthesized. Their chemical identities were elucidated by elemental analyses, IR, 1H-NMR, 13C-NMR and mass spectral data. The percentage of the geometrical isomers was also elucidated using the 1H-NMR. The synthesized compounds were selected for screening at the Tuberculosis Antimicrobial Acquisition and Coordination Facility (TAACF) against Mycobacterium tuberculosis H37Rv strain in which they showed moderate activity at a concentration of 6.25 g/ml. Moreover, antimicrobial screenings against E. coli (ATCC 25922), S. aureus (ATCC 19433) and C. albicans identified compound 4g as the most effective showing similar antibacterial activity as ampicillin against S. aureus.
https://bpsa.journals.ekb.eg/article_65187.html
https://bpsa.journals.ekb.eg/article_65187_496c97778eb3f2b4dc0ad449ee02d6bd.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
REACTIVITY OF CERTAIN BIOLOGICALLY IMPORTANT AZOLES AND MORPHOLINE TOWARDS Ni(II) AND Cu(II) COMPLEXES OF o-HYDROXYACETOPHENONEETHANOLIMINE AND N-SALICYLIDENE DERIVATIVES
134
149
EN
Aref
A. M.
Aly
Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt
Ahmed
H.
Osman
Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt
Mohamed
Abd
El-Mottaleb
Department of Chemistry, Faculty of Science, Al-Azhar University (Assiut), Egypt
Gamal
A.H.
Gouda
Department of Chemistry, Faculty of Science, Al-Azhar University (Assiut), Egypt
10.21608/bfsa.2006.65188
A number of mixed ligand complexes of Ni(II) and Cu(II) containing the Schiff bases: o-hydroxyacetophenoneethanolimine (OHAE), N-salicylidene-o-iminophenol (SOP) and N-salicylideneo-toluidine (SOT) as well as morpholine or the azoles: 2aminothiazole, benzothiazole and 2-methylbenzothiazole has been prepared and characterized. The IR, UV-VIS spectra and magnetic moment measurements of the complexes were discussed.
https://bpsa.journals.ekb.eg/article_65188.html
https://bpsa.journals.ekb.eg/article_65188_67af6f9edf33efc9b8e3d20f4b082a78.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA
151
165
EN
Safwat
Ahmed
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
Mostafa
Mesbah
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
Diaa
Youssef
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
Sherief
Khalifa
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
10.21608/bfsa.2006.65189
Two new metabolites, a diglyceride ester, corticaglyceride (1) and a sphingolipid, corticaceramide (5) were isolated and characterized from the Red Sea sponge Negombata corticata (Carter). Other previously reported compounds including nervonic acid (2), 24-methylene cholesterol (3) and cholesterol (4) were also isolated for the first time from this genus. GLC analysis of the unsaponifiable matter revealed that it contained a high percentage of hydrocarbons (89.474%) with n-hexacosane as a major component (10.979%). Furthermore, the identified sterol represents 7.162%. GLC analysis of the fatty acid methyl esters revealed that nervonic acid is the major fatty acid (73.782%). Compound 3 showed anti-inflammatory activity, while compounds 1 and 5 showed mild anti-oxidant properties.
https://bpsa.journals.ekb.eg/article_65189.html
https://bpsa.journals.ekb.eg/article_65189_a313f14aa31618036185d173a1c96ba4.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
BRONCHIAL ASTHMA AND COPD: IMPACT OF PHARMACEUTICAL CARE ON OUTCOMES AND QUALITY OF LIFE IN EGYPTIAN PATIENTS
167
185
EN
Abdel-Hameed
I. M.
Ebid
Department of Pharmacy Practice, Faculty of Pharmacy, Helwan University
Emad
Abdel-Wahab
Department of Chest Diseases, Faculty of Medicine, Ain-Shams University
10.21608/bfsa.2006.65190
This work was performed to assess whether a pharmaceutical care program improves outcomes and optimizes quality of life in Egyptian patients with bronchial asthma or chronic obstructive pulmonary disease (COPD). Three hundred and fifty adult patients with bronchial asthma or COPD were selected from the out-patient chest clinics, El-Demerdash hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt; from January 2003 to August 2004. Participants were divided into 175 patients for whom the program was implemented and the remaining 175 patients were considered as control; received the hospital usual care. Patients at the out-patient chest clinics were invited to participate in the pharmaceutical care program. The program consisted of scheduled meetings between the pharmacist and patients to assess drug therapy, plan goals, and intervene through counseling and/or consultation with other health professionals. Three primary parameters were measured monthly. First: health-related quality of life (HRQOL). Second: clinical outcomes including change in peak expiratory flow rate (PEFR), physical findings, numbers of visits to clinics’ and emergency department (ED) and hospitalization. Third: the costs. Results showed great statistically significant improvements in HRQOL and the clinical outcome for patients in the intervention group; either asthmatics or patients with COPD, compared with control groups. The monthly average costs were statistically significantly higher for the control group in comparison with either asthmatics or patients with COPD in the intervention group. In conclusion: results from this study provide evidence that through providing structured, co-operative, patientoriented pharmaceutical care, pharmacists can help patients with reactive airway disease achieve desired health outcomes, optimize health related quality of life in realistic economic parameters. Recommendation: Pharmaceutical care would have maximum impact if its effect on patients' outcomes could be demonstrated in community pharmacies by well trained pharmacist. Community pharmacies have the capacity to rapidly implement programs system-wide. However, for programs to be integrated into these pharmacies, a rigorous change in pharmacy education in Egypt will be necessary.
https://bpsa.journals.ekb.eg/article_65190.html
https://bpsa.journals.ekb.eg/article_65190_6aec0c940479efd30b2aaa57ab639f93.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
EFFECT OF ORGANIC MANURES AND CHEMICAL FERTILIZERS ON FOENICULUM VULGARE, MILL AND CARUM CARVI, L.
187
201
EN
Souzan
M.
Ibrahim
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt
Hosny
M.
El-Labban
Department of Horticulture, Faculty of Agriculture, Tanta University, Tanta, Egypt
Fayez
I.
Mohamed
Department of Horticulture Res. Inst., Agricultural Research Center, Egypt
Neveen
M.
Naga
Department of Horticulture, Faculty of Agriculture, Tanta University, Tanta, Egypt
10.21608/bfsa.2006.65191
The effect of organic manures and chemical fertilizers on the vegetative growth and oil production and composition for both plants were studied. The experiments were carried out during two seasons of 2001/2002 and 2002/2003. Three concentration from each of farmyard manure, FYM (8,12 and 16 m3/fed), chicken manure, CM (0.8, 1.2 and 1.6 m3/fed) and mixed manures of FYM + CM (4 + 0.4, 6 + 0.6 and 8 + 0.8 m3/fed) were added at the time of soil preparation. The chemical fertilizers N and K were used as soil dressing two times after 50 and 75 days from planting. The results indicated that the use of FYM, 16 m3/fed treatment produced high vegetative growth and high fruit yield/fed in both plants as well as high values of NPK for fennel plant. The high oil yield was produced from the use of the mixed treatment FYM + CM 4 + 0.4 m3/fed and by the use of CM, 1.2 m3/fed in case of fennel and caraway plants respectively. The dose of CM, 1.2 m3/fed with caraway also produce high values of NPK.
https://bpsa.journals.ekb.eg/article_65191.html
https://bpsa.journals.ekb.eg/article_65191_a8bedac16c2350ddaff40a0618d55923.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
A NEW FLAVONOL GLYCOSIDE FROM POLYGONUM BELLARDII ALL. GROWING IN EGYPT
203
213
EN
M.
H.
Mohamed
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt
Z.
Z.
Ibraheim
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
A.
M. A.
Abd El-Mawla
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
A.
M.
Abd El-Kader
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt
10.21608/bfsa.2006.65192
A new flavonol glycoside named myricetin-3-O-(5''-acetyl αarabinofuranoside) has been isolated from Polygonum bellardii All. F. Polygonaceae growing in Egypt, together with quercetin-3O-(5''-acetyl α-arabinofuranoside), quercetin-3-O-rutinoside (rutin), α-amyrin, β-sitosterol and β-sitosterol-3-O-β-glucoside. Their structures were elucidated using different spectral techniques.
https://bpsa.journals.ekb.eg/article_65192.html
https://bpsa.journals.ekb.eg/article_65192_e4d583b91ddfc8f8f009a0a0b982162f.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
29
1
2006
06
30
IRIDOIDS WITH ANTIMICROBIAL ACTIVITY FROM PLUMERIA ALBA L.
215
223
EN
Mohammad
S.
Afifi
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
Osama
M.
Salama
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
Ahmad
A.
Gohar
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
Amani
M.
Marzouk
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
10.21608/bfsa.2006.65194
Three major iridoids; viz. plumieride, protoplumericin A and plumieride acid were isolated from the bark and leaves of Plumeria alba L. Protoplumericin A and plumieride acid are reported for the first time from the titled plant. These compounds were identified through different chemical and spectroscopic methods. They displayed distinct activity against some pathogenic bacteria and fungi.
https://bpsa.journals.ekb.eg/article_65194.html
https://bpsa.journals.ekb.eg/article_65194_1eacaeb90d7550fe185a950bc8bf3d79.pdf