Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
23
2
2000
12
31
Effect of natural polymers on the physicochemical properties and ulcerogenic activity of piroxicam
91
98
EN
T.
H.
El-Faham
Department of Pharmaceutics, Faculty of Pharmacy and Department of Histology,Faculty of Medicine, Assiut University, Assiut 71526, Egypt
M.
Mahmoud
Department of Pharmaceutics, Faculty of Pharmacy and Department of Histology
M.
A.
Hassan
Department of Pharmaceutics, Faculty of Pharmacy and Department of Histology, Faculty of Medicine, Assiut University, Assiut 71526, Egypt
10.21608/bfsa.2000.66136
Piroxicam belongs to the class of acidic non-steroidal antiinflammatory drugs. Under the acidic conditions in which its absorption takes place, its low soly. and dissoln. rate has been well documented. The effect of natural polymers such as pectin, lecithin, sodium alginate and gelatin on the physicochem. properties of piroxicam has been studied. Dispersions of these polymers with the drug were prepd. in different wt. ratios by the kneading method. The dissoln. rate of the drug decreased in presence of all these polymers except gelatin. Gelatin showed enhancing influence on piroxicam dissoln. A slight increase in dissoln. was also obtained with 1:2 drug-pectin ratio. The soly. of piroxicam decreased in the presence of different concns. of either pectin or lecithin but increased in the presence of different concns. of gelatin and sodium alginate. The interaction of these polymers and piroxicam was traced by x-ray diffraction and IR spectroscopy. In addn., piroxicam-induced gastric lesions in rats, disappeared by dispersing the drug in gelatin. Histol. studies showed intact surface epithelium and fundic glands in case of piroxicam-gelatin dispersion. So, piroxicam-gelatin dispersed mixt. is recommended to increase the dissoln. of the drug and protect against ulcerogenic activity.
https://bpsa.journals.ekb.eg/article_66136.html
https://bpsa.journals.ekb.eg/article_66136_5acea372208f93b9a1a20be14a0a93f2.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
23
2
2000
12
31
Chemical and biological studies of Sinapis arvensis growing in Egypt
99
109
EN
A.
A.
Ali
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University Assiut 71526, Egypt
H.
A.
Hassanean
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University Assiut 71526, Egypt
M.
Mohammed
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt
M.
S.
Kamel
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University Assiut 71526, Egypt
E.
S.
El-Khayat
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt
10.21608/bfsa.2000.66323
From the Et acetate fraction of the alc. ext. of the flowers of Sinapis arvensis L. a new compd. given the name: (2,2'-diacetyloxy-3,3'-dihydroxy)-1,1'-dipropylether. In addn., three flavonoidal glycosides were also isolated and identified as: kaempferol-3-O-β-glucopyranoside, isorhamnetin-3,7-O-β-diglucopyranoside and isorhamnetin-3-O-β-glucopyranoside-7-O-α-rhamnopyranoside. Meanwhile the chloroform fraction of the alc. ext. of the seeds afforded β-amyrin, β-sitosterol, β-sitosterol-3-O-β-glucopyranoside and syringin. The GC/MS anal. of the fixed oil of the seeds revealed the presence of 14 fatty acids including a high percent (11.56%) of harmful erucic acid. The identification of the isolated compds. was based on different methods of phys., chem. and spectral anal. Moreover the biol. screening showed that the alc. ext. of the leaf, the flavonoids of the flower and to a lesser extent the oil of the seed possesses a significant antimicrobial activity, while the flavonoids of the flower showed a significant anti-inflammatory activity. In addn., the oil of the seed showed insignificant diuretic activity.
https://bpsa.journals.ekb.eg/article_66323.html
https://bpsa.journals.ekb.eg/article_66323_6e174914ed0850f62cdd807b47fb0854.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
23
2
2000
12
31
Phenolic compounds from Ailanthus altissima Swingle
111
116
EN
A.
M.
Abd El-Baky
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
F.
M.
Darwish
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Z.
Z.
lbraheim
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Y.
Gh.
Gouda
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.2000.66324
The phenolic compds., Et gallate, kaempferol, quercetin, kaempferol-3-O-glucoside, quercetin-3-O-glucoside and rutin were isolated from the leaves of Ailanthus altissima together with β-sitosterol, ceryl alc. and β-sitosterol glucoside
https://bpsa.journals.ekb.eg/article_66324.html
https://bpsa.journals.ekb.eg/article_66324_84e4ac2ff6dd8fc0cd6868dc7c0f7db4.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
23
2
2000
12
31
ALKALOIDS AND ISOFLAVONOIDS FROM LUPINUS PUBESCENS BENTH
117
123
EN
A.
A.
Khalifa
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
10.21608/bfsa.2000.66325
From the 75% alc. ext. of Lupinus pubescens Benth herb 5 isoflavonoids were isolated and identified as genistein, luteone, 2'-hydroxy genistein, genistein-7-O-β-glucoside and geneistein-4'-O-β-glucoside, in addn. to β-sitosterol glucoside. More over 3 quinolizidine alkaloids were isolated from the herb of the plant namely (+)-17-oxosparteine, (+)-17-oxolupanine and 5,6-dehydrolupanine. The structure of the isolated compds. was established by spectroscopic methods, as well as comparison of the isolated alkaloids with authentic samples.
https://bpsa.journals.ekb.eg/article_66325.html
https://bpsa.journals.ekb.eg/article_66325_842b550505ac5b64f4d8794b7c96b22d.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
23
2
2000
12
31
New chiral amine ligands for enantioselective synthesis of certain (S)- and (R)-monobactams
125
136
EN
M.
A.
Hussein
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut-71526, Egypt
A.
A.
El-Shorbagi
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut-71526, Egypt
N.
M.
Omar
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut-71526, Egypt
Z.
S.
Farghaly
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut-71526, Egypt
Kiyoshi
Tomioka
Graduate School of Pharmaceutical Sciences, Department of Synthetic Medicinal Chemistry, Kyoto University, Sakyo-Ku, 606-01, Japan
10.21608/bfsa.2000.66367
Two new tridentate chiral amine ligands I and II mediated the condensation reaction of lithium ester enolate III with benzaldehyde p-anisidineimine IV providing selectively the required (S)- or (R)-monobactam V. It is also noticed that the coexistence of III and chiral lithium amides that formed -in situ- from I,II is an important factor for the enhancement of the reactivity and enantioselectivity of III.<br /> <em> </em>
https://bpsa.journals.ekb.eg/article_66367.html
https://bpsa.journals.ekb.eg/article_66367_80273cf6045f7fda5ccf022bcb752313.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
23
2
2000
12
31
Influence of liquorice on the blood glucose, potassium and sodium levels and its interaction with insulin in normal, diabetic and adrenalectomized rats
137
145
EN
A.
E. A.
El-Koussi
Department of Pharmacology, Faculty of Medicine, Assiut University
S.
A.
Mangoura
Department of Pharmacology, Assiut Faculty of Medicine, Al-Azhar University
H.
H.
Abu Rahma
Department of Pharmacology, Assiut Faculty of Medicine, Al-Azhar University
A.
Abu El Wafa
Department of Pharmacology, Assiut Faculty of Pharmacy, Al-Azhar University
10.21608/bfsa.2000.66399
its reported hyperglycemic effect. The aim of the present study was to evaluate this possible effect in both normal and diabetic rats. The mechanism of this hyperglycemic effect of liquorice was also investigated by studying the role of the adrenal glands after giving liquorice to adrenalectomized rats. The effect of liquorice on the hypoglycemic effect of insulin as well as its effect on the plasma electrolyte (Na<sup>+</sup> & K<sup>+</sup>) levels were also studied. Results of this study revealed that liquorice (5.2 g/kg, orally) produces a significant (P<0.05) increase in the blood glucose level (B.G.L) in both normal and diabetic rats but not in adrenalectomized rats. Concurrent administration of insulin (0.5 u/kg) and liquorice produced an inhibition of the insulin-induced hypoglycemia in both normal and diabetic animals. However, liquorice ingestion did not affect the insulin hypoglycemic effect in adrenalectomized rats. Oral administration of liquorice (5.2 g/kg) produced a significant (P<0.05) redn. in plasma potassium and elevation in plasma sodium levels in both normal and diabetic animals. However, in adrenalectomized animals, liquorice failed to produce a significant change in plasma electrolyte (Na<sup>+</sup> & K<sup>+</sup>) levels. Results of the present work support the previous reports concerning the various hazards of liquorice frequent administration to normal and diabetic individuals. According to our data, the most important of these hazards are hyperglycemia, inhibition of insulin induced hypoglycemia, hypokalemia and hypernatremia. Our results may also support the assumption of the possible direct or indirect glucomineralocorticoid activity of liquorice.
https://bpsa.journals.ekb.eg/article_66399.html
https://bpsa.journals.ekb.eg/article_66399_ef726f68dade82954242fed22acb3e5d.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
23
2
2000
12
31
In vitro release of chloramphenicol sodium succinate from Eudragit polymeric films
147
156
EN
A.
E.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Egypt
S.
H.
Khidr
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Egypt
E.
M.
Samy
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Egypt
A.
Ismail
Department of Pharmaceutics and Industrial Pharmacy, Al-zhar University
M.
A.
Amin
Department of Pharmaceutics and Industrial Pharmacy, Al-zhar University
10.21608/bfsa.2000.66400
Eudragit polymeric films were investigated as potential drug delivery systems for the controlled release of chloramphenicol sodium succinate (CSS). CSS at 10% wt./wt. in polymeric film of Eudragit RL100, plasticized with glycerol triacetate (GTA), glycerol tributyrate (GTB), propylene glycol (PG) or di-Me phthalate (DMP) was prepd. Increasing drug release rate from Eudragit RL100 films due to plasticizers could be arranged as follows: GTA > PG > DMP > GTB. The release of CSS in polymeric film of Eudragit RL100 was studied as a function of initial drug concn. and GTA content. The release rate const. of the drug was found to be proportional to drug concn. and GTA content in the film. CSS films composed of different ratios of Eudragit RS100 and Eudragit RL100 were prepd. The results show that CSS release from film contg. Eudragit RS100/RL100 at a ratio of 2:8 was higher than those of the other polymer ratios. The effect of addn. of different concns. of hydroxypropyl methylcellulose (HPMC) to Eudragit RS100 films on the release rate of CSS was also studied. The best concn. of HPMC on increasing the release rate of the drug was found to be 10% wt./wt. The results indicate that drug release from matrix follows a diffusion-controlled model. The min. inhibitory concn. (MIC) of CSS for Staphylococcus aureus, Bacillus cereus, E. coli and Candida albicans was investigated. Results indicated that MIC of CSS was ranged from 7 to 12 μg/mL. The inhibition zone diams. of CSS film composed of Eudragit RS100/RL100 (2:8) were higher than that of CSS gauze dressing. In-vitro antimicrobial activity of CSS was enhanced in Eudragit RS100/RL100 film plasticized with 20% GTA in presence of 10% Tween 80.
https://bpsa.journals.ekb.eg/article_66400.html
https://bpsa.journals.ekb.eg/article_66400_9022b4927196fea7972c0344b533badc.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
23
2
2000
12
31
SPECTROPHOTOMETRIC DETERMINATION OF FAMOTIDINE USING P-CBLORANILIC ACID
156
163
EN
H.
A.
Mohamed
Department of Pharmaceutical Analytical Chemistry, Assiut University, Egypt
10.21608/bfsa.2000.66402
<em>Simple and accurate spectrophotometric method/or the analysis of famotidine have been presented. The method was based on the interaction of famotidine and p-chloranillc acid (pCA) in acetonitrile to give a stable and purple colored product measured at 521 nm. The first derivative value of the interaction product with p-CA was also measured at 323 nm. The optimum experimental parameters have been worked out. Beer's law was obeyed from 25 to 240 µglml and from 2 to 30 µg/ml for the direct absorbance and first derivative measurements respectively. The method enabled the assay of famotidine in its tablets. The derivative method was applied for the determination of famotidine in tablets and spiked urine. Recovery was quantitative and relative standard deviation did not exceed 2 %. </em><br /> <em> </em>
https://bpsa.journals.ekb.eg/article_66402.html
https://bpsa.journals.ekb.eg/article_66402_14e6b910092a63a1fa67968c3a1ef38a.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
23
2
2000
12
31
Ocular delivery of flurbiprofen from ophthalmic liposomes dispersed in thermosensitive gel
165
175
EN
A.
Abd-Elmageed
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
F.
Yamashita
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
M.
Hashida
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
10.21608/bfsa.2000.66403
In order to maintain adequate drug levels in ocular tissues, frequent drug instillation is necessary in treatment of ophthalmic disorders. Flurbiprofen, NSAIDs, was entrapped in EPC liposomes dispersed in thermosensitive polaxamer gel. The size and Zeta-potential of the vesicles were analyzed. The in-vitro leakage of the entrapped and free drug were carried out under sink condition, the t1/2 for entrapped drug was 4.1 fold when compared to that of the free drug. The concns. of Flurbiprofen in the ocular tissues of the rabbits for both formulations (entrapped and free drug) were detd. by HPLC measurement. The in-vivo study depicted that entrapment of the drug in liposomes enhanced the drug precorneal retention, drug penetration and consequently increased the drug levels in ocular tissues compared to free drug formulation. The study also revealed that, the highest drug level deposited in the cornea and sclera followed by aq. humor and vitreous body. The pharmacokinetic parameters (AUC and C<sub>max</sub>) and the significance t-test levels (P values) for the difference between entrapped and free drug were calcd. It was found that the majority of differences were very highly to highly significant. These findings indicate that entrapment of drug in liposomes may be promising formulation, particularly when dispersed in highly viscous system, for ophthalmic therapeutic use.<br />
https://bpsa.journals.ekb.eg/article_66403.html
https://bpsa.journals.ekb.eg/article_66403_ea7ac051fe5a7f2e2afedbfd10f2af34.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3009-7703
23
2
2000
12
31
Isoflavones and a saponin from Crotalaria thebaica (Del.) DC growing in Egypt
177
186
EN
Z.
Z.
lbraheim
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
A.
Khalifa
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
10.21608/bfsa.2000.66404
Further investigation of the dried aerial parts of Crotalaria thebaica (Del.) DC. led to the isolation of two isoflavone aglycons; Biochanin A and Genistein, an isoflavone-O-glucoside; Biochanin A-7-O-β-glucoside, 2 isoflavone C-glycosides identified as 8-C-glucosyl genistein and 6,8-di-C-glucosyl biochanin A and a saponin glycoside identified as robinioside C Me ester . <br /> The identification of the isolated compds. was based on chem. and spectral studies.
https://bpsa.journals.ekb.eg/article_66404.html
https://bpsa.journals.ekb.eg/article_66404_847a7c6704f622a3a0b4798d605d82e6.pdf