2024-03-29T00:14:23Z
https://bpsa.journals.ekb.eg/?_action=export&rf=summon&issue=9598
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2007
30
1
THE SEPARATION AND STUDY OF THE BIOLOGICAL ACTIVITY OF GLYCAN OF SONCHUS OLERACEUS L. HERB FAMILY ASTERACEAE
M.
El-Aassar
K.
Abou El-Seoud
I.
El-Shami
The wide biological and therapeutic applications of Asteraceaefamily motivated our attention to search on plant related to thisfamily in our local flora. So, Sonchus oleraceus L. was the chosenplant.
The monomeric composition of the partially and completelyhydrolysates of S. oleraceus L. herb crude polysaccharide complexwas determined using GC/MS analysis. The obtained resultsrevealed the presence of mannose, xylose, arabinose, glucose,galactose and glucuronic acid.To determine the polymeric composition of the polysaccharidecomplex, different methods of fractionation were used.Demineralization was done first, then saponification. Thedemineralized glycan was chromatographed on DEAE-cellulosecolumn. Elution being monitored spectrophotometrically usingphenol-sulphuric acid reagent. The result revealed that thedemineralized glycan composed of 1 major polymer. Both acidicand neutral monomers of the partially hydrolysed fractions weresubjected to silylation and GC/MS analysis which providequalitative and quantitative determination of the monomericcomposition of each fraction. The polysaccharide complex was anacidic heterogenous polysaccharide.The crude glycan of S. oleraceus L. herb showed significantanti-inflammatory effect and powerful hepatoprotective actionagainst CCl4 induced hepatotoxicity in rats. Further investigationof hepatoprotective effect of demineralized, fraction I and fractionII glycans were done and the results were compared with that of thecrude glycan. All of these glycans had powerful hepatoprotectiveaction against CCl4 induced hepatotoxicity. Fraction I glycan(containing glucuronic acid) had the highest hepatoprotectiveactivity.
2007
06
30
1
22
https://bpsa.journals.ekb.eg/article_63541_f2bca320606e7e4881c707bb393acac9.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2007
30
1
A PHARMACOGNOSTICAL STUDY OF MONSONIA NIVEA DECNE. WEBB. GROWING IN EGYPT
Mohamed
Afifi
Madiha
Hassan
Zain-EL Abden
Naeim
Weaam
Elsayed
The macro- and micro-morphological characters of the leaves,petioles, stems and roots of Monsonia nivea Decne.Webb. (FamilyGeraniaceae) have been studied in order to identify them in bothentire and powdered forms.
2007
06
30
23
37
https://bpsa.journals.ekb.eg/article_63542_a2af817bd12099d083f60cad881b5557.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2007
30
1
SYNTHESIS AND QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (QSAR) STUDY OF NEW 3- ALLYL-5-SUBSTITUTED-3,4,5,6-TETRAHYDRO-2H-1,3,5- THIADIAZINE-2-THIONES OF A POTENTIAL ANTIMICROBIAL ACTIVITY
Alaa
Hayallah
Awwad
Radwan
Fifteen new 3-allyl-5-substituted-3,4,5,6-tetrahydro-2H-1,3,5-thiadiazine-2-thiones were synthesized by the reaction of allylaminewith carbon disulfide and potassium hydroxide, followed byformaldehyde and appropriate primary amine such as alkyl,aralkylamines, glycine, L-alanine or ethyl glycine ester. The titlecompounds were tested, in vitro, for antimicrobial activity againstgram-positive bacteria (Bacillus cereus, Staphylococcus aureus,Micrococcus leuteus), Gram-negative bacteria (Escherichia coli,Serratia marcescens, Pseudomonas aeruginosa), and some fungi(Aspergillus flavus, Aspergillus niger, candida albicans,Geotrichum candidum, Scopulariopsis brevicaulis and Trichophytonrubrum), using agar disc method. Quantitative structureactivity relationship study was performed using the log form ofMIC against Scopulariopsis brevicaulis fungi and some physicochemicaldescriptors (MR, L, and Fr) of substituents at N-5 position. The log MIC were found to be negatively linearly correlatedwith MR and L and positively linearly correlated with Fr.
2007
06
30
39
50
https://bpsa.journals.ekb.eg/article_63543_c7990918c62a8dbbc702d38841a9a5af.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2007
30
1
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL 2,3-DISUBSTITUTED QUINAZOLIN4(3H)ONES
Safinaz
Abbas
Amal
Saafan
3-Amino-2-(substituted phenoxymethyl / propyl) quinazolin4(3H)ones 4a-c have been prepared. Refluxing 4 with 5-nitro-2furaldehyde / 4-nitrobenzaldehyde afforded the corresponding substituted methylidene-amino derivatives 5 and 6 respectively. Reaction of 4 with isatin yielded the indolylideneamino derivatives 7. Refluxing 4 with ofloxacin acid chloride furnished the corresponding carboxamides 8. Reaction of chloroacetyl chloride with 4c produced the 3-chloroacetylamino derivative 9 which upon further reaction with the potassium salts of some antibacterial acids gave the corresponding carboxylate derivatives 10. Sixteen compounds were screened for their antibacterial and antifungal activities. Thirteen compounds were found to possess (high to moderate) activity against Pseudomonas aerugenosa and some of them were also active against Escherichia coli. Only one compound was found to exhibit moderate antifungal activity against Candida albicans.
2007
12
30
51
62
https://bpsa.journals.ekb.eg/article_63639_6320d6a86cfc1d6805b2b19e13284145.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2007
30
1
SYNTHESIS AND ANTIDEPRESSANT ACTIVITY OF SOME NOVEL FLUOXETINE DERIVATIVES
H.
Safwat
S.
Abbas
S.
Mohamed
M.
Fouad
M.
Elmazar
The present work involves the synthesis of three series of novel fluoxetine derivatives in order to evaluate their potential as antidepressants. The first series consists of 1-methyl-1-[3-phenyl-3(4-trifluoromethylphenoxy)propyl]-3-substituted ureas 2a-c and thioureas as their bioisosters 3a-m which were prepared by reacting fluoxetine 1a with different isocyanates and isothiocyanates respectively. The second series N-acyl/aroyl-Nmethyl-3-phenyl-3-(4-trifluoromethylphenoxy)-propylamines 4a-d were synthesized by refluxing 1a with acyl/aroyl chloride and trifluoroacetic anhydride. The third one, N-chloroacyl-fluoxetine 5a-c was obtained via the reaction of 1a with chloroacyl chloride. In addition to a propionitrile derivative 8 which was achieved by refluxing 1a with acrylonitrile. The twenty four final compounds were biologically screened throughout the work for their potential as serotonin reuptake inhibitors by measuring potentiation of 5HTP induced neurotoxity and some as norepinephrine reuptake inhibitor by measuring yohimbine-induced mortality in mice to calculate5-HTP/NE ratio as a parameter for selectivity to inhibit serotonin reuptake. Four compounds (3e, 3h, 3i, 5b) were found to be as potent as fluoxetine.
2007
06
30
63
80
https://bpsa.journals.ekb.eg/article_63645_7fa0f0e1d771b36a11de5c5dc6b0aa7a.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2007
30
1
ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES OF SPICES
Naser
Al-Wabel
This article presents a brief summary about the possible antimicrobial and antioxidant properties of some well known and widely used species. The author emphasizes on the previously reported studies which were carried out to reveal the antimicrobial and antioxidant properties of species commonly used throughout the world. In addition, the usefulness of these species as preservatives, antioxidants and aroma as well as flavoring agents is discussed
2007
06
30
81
87
https://bpsa.journals.ekb.eg/article_63651_a273e8ed50a16ca01b3014f4cbcf71ff.pdf