2024-03-28T20:02:53Z
https://bpsa.journals.ekb.eg/?_action=export&rf=summon&issue=9910
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
New quaternary alkaloid and other constituents and biological activities of Cadaba glandulosa F.
A.
Attia
A new quaternary alkaloid named cadabine A and β-sitosterol, β-sitosterol glucoside, kaempferol-3,7-dimethyl ether, quercetin, kaempferol-3-O-glucoside, quercetin-3-O-rutinoside and stachydrine were isolated from the title plant. Identification of these compds. was established by phys. and spectral data and by comparison with the authentic samples. In addn., biol. activities of the ethanolic ext. were investigated.
2002
12
31
115
124
https://bpsa.journals.ekb.eg/article_65685_d836f19461b247612816eefe676cbff8.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
Formulation and evaluation of bucco-adhesive natamycin tablet
Gamal
El-Gindy
Ahmed
El-Sayed
Abdel-Razzak
Magied
Ghareb
Abdel-Aal
Bucco-adhesive erodible tablets for local delivery of natamycin (NTM) to the oral cavity were prepd. by the direct compression method using different bioadhesive polymers and sol. excipients like mannitol and polyethylene glycol 6000. Preformulation studies were carried out by using DSC and IR to show that there is no interaction between drug and carrier systems. The tablets were evaluated for drug content uniformity, friability, hardness, swelling index and surface pH. The in vitro bio-adhesive strength and release characteristics were a function of the type of the polymer and also the total compn. of the tablets. In vivo evaluation of placebo bucco-adhesive tablets revealed adequate comfort, taste and non-irritancy during the period of the study. The bucco-adhesive tablets eroded completely leaving no exhausting device to be removed. None of the volunteers reported severe dry mouth, severe salivation or heaviness at the place of attachment. The selected formulation was able to maintain the salivary concn. of NTM above the MIC against Candida albicans for up to 6 h.
2002
12
31
125
135
https://bpsa.journals.ekb.eg/article_65687_76726d1990d4c04174abbef3f016d178.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
Spectrophotometric and spectrofluorimetric determination of trimebutine
Hanaa
Abdel-Wadood
Two simple, rapid and sensitive spectrophotometric and spectrofluorimetric methods have been developed for the detn. of trimebutine in bulk drug, pharmaceutical prepns. and in urine. The first method depends on ion-pair complex reaction of trimebutine with two indicators, bromophenol blue (BPB) and thymol blue (TB), in methanol. Different variables affecting the reactions were studied and optimized. The colored products of the drug with bromophenol blue and thymol blue were extd. and measured at 415 and 425 nm, resp. Beer's law was obeyed in the concn. ranges 7-60 μg ml-1 and 5-30 μg ml-1 for BPB and TB resp. The spectrofluorimetric method depends on the condensation of malonic acid and acetic anhydride under the catalytic effect of trimebutine. The condensation product gave emission light measured at 430 nm (excitation at 390 nm). Calibration range gave good correlation in the range of 0.8-80 ng ml-1. The proposed methods were applied for estn. of the drug in different pharmaceutical prepns. without interference from common encountered additives. Percentage recoveries ranged from 98.4% to 101.5%. The fluorimetric method was applied for the detn. of drug in urine and gave good recoveries ranging from 98.45 to 102.15% for spiked concn. in the range 0.01 to 1.00 mg ml-1 and the measured concn. ranged from 0.8 to 80 ng ml-1.
2002
12
31
137
144
https://bpsa.journals.ekb.eg/article_65691_fda3142ac02c22a758d9f6de1f329e3c.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
Formulation of azapropazone ophthalmic preparations using cyclodextrins as complexing agents
Osama
Soliman
The effect of cyclodextrins (CyDs), hydroxypropyl β-cyclodextrin (HP-β-CyD) and β-cyclodextrin (β-CyD) on the soly. and release characteristics of azapropazone (Az) was investigated. The aq. soly. of azapropazone was significantly increased by the formation of water sol. (1:1) inclusion complexes with CyDs. Also, the soly. of azapropazone increased linearly as a function of HP-β-CyD followed by β-CyD. The ophthalmic formulations (drops, gels and ophthalmic inserts) were prepd. using aq. vehicles contg. sodium CM-cellulose and carbopol 941 mixt. at different concns. The amts. released of azapropazone front eye drops, gels and ophthalmic inserts contg. the drug complexes with CyDs in (1:1) molar ratio were significantly higher than formulations contg. the drug alone. In addn., the in vitro availability of the drug from drops was higher than gels or and ophthalmic inserts at different time intervals.
2002
12
31
145
153
https://bpsa.journals.ekb.eg/article_65692_aff60e334fbe27da8c2b0150991f5851.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
Triterpenes from Rubia cordifolia L
Zedan
Ibraheim
From the hexane fraction of the methanol-chloroform (1:1) ext. of the dried roots of Rubia cordifolia L., three new and five known triterpenoidal compds. were isolated and identified. The new triterpenes are 3β-acetoxyoleanane-12-one (I), 3β,13β,15α-trihydroxyoleanane-12-one (II) and 3β,19α-dihydroxyarbor-9(11)-ene (III). The known triterpenes are 3β-acetoxyoleanane-13β-ol-12-one, 3β-acetoxyoleanane-13β,15α-dihydroxyoleanane-12-one, oleanolic acid and its acetate, and hederagenin. The identification of the isolated compds. was carried out using different phys., chem. and spectral methods of anal. The cytotoxic activity of some of the isolated compds. was studied.
2002
12
31
155
163
https://bpsa.journals.ekb.eg/article_65694_75a09e4eb2b321446717b0501104c9f1.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
Phytochemical study of Jacaranda ovalifolia R. Br. family Bignoniaceae cultivated in Egypt
Yaser
Gouda
Afaf
Abdel-Baky
Faten
Darwish
Khaled
Mohamed
Ryoji
Kasai
Kazuo
Yamasaki
Eight compds. were isolated from the leaves of Jacaranda ovalifolia R. Br. and were identified as: 6'-Ph acetic acid ester of glucose (1), Me p-hydroxy Ph acetate (2), zizybeoside 1 (3), phenethyl alc. 8-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (4), acteoside (5), isoacteoside (6), apigenin 7-O-β-D-glucuronopyranoside (7), and jacaranone (8). The structures of the compds. were detd. by phys., chem. and spectroscopic methods. Compd. 1 is isolated here probably for the first time from a natural source, compds. 2, 3, 4, 6 and 7 have been isolated for the first time from the genus Jacaranda, compd. 8 was isolated for the first time from J. ovalifolia R. Br., and compd. 5 was previously isolated from J. ovalifolia.
2002
12
31
165
174
https://bpsa.journals.ekb.eg/article_65695_f3bf3cd6056c4ab9166f76b11db9b033.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
Study of some characteristics of egg-lecithin liposomes prepared by extrusion and freeze-thawing method
M.
El-Badry
Liposomes were prepd. by extrusion and freeze-thawing method using carboxyfluorescein as marker. The effect of the no. of extrusion, Freeze-thawing cycles on lipid content, liposome size and encapsulation efficiency was investigated. The results revealed that, there was a direct relationship between the membrane pore size and particle size of liposomes. However, there was an inverse relation between the no. of extrusion cycles and size of liposomes. In the meantime, increasing the no. of extrusion cycles produced homogeneous liposomes. Also an inverse relation was found between the no. of extrusion cycles and encapsulation efficiency of the marker. Freeze-thawing process offered high encapsulation efficiency of carboxyfluorescein inside liposomes.
2002
12
31
175
179
https://bpsa.journals.ekb.eg/article_65696_ba6cdb8c2c24523116cbca30039a5c20.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
In vivo evaluation of azapropazone cyclodextrin complexes from ophthalmic formulations/ocular tolerance and disposition in eye tissues
Osama
Soliman
Galal
Abd El-Ghany
Mohamed
Fathy
The effect of inclusion complex formation of azapropazone (Az) with cyclodextrins (CyDs), hydroxypropyl β-cyclodextrin (HP-β-CyD) and β-cyclodextrin (β-CyD) on the bioavailability of the drug in rabbits eye tissues (conjunctiva, cornea, iris-ciliary body and aq. humor) front ophthalmic prepns. (drops, gels and inserts) contg. the drug or its complexes were studied. The solid inclusion complexes of Az were prepd. by the kneading method in molar ratios of 1:1 (guest/host) with HP-β-CyD or β-CyD. The prepd. complexes were investigated by the soly. method. The enhancing effect of HP-β-CyD on the penetration of Az in various eye tissues was greater than that of β-CyD. The in-vivo availability of Az from the tested ophthalmic prepns. in eye tissues were arranged as following; conjunctiva > cornea > iris-ciliary body > aq. humor. The peak time of Az for all formulations in the various eye tissues was 4 h. Meanwhile, AUCs of total drug disposition in the different eye tissues were 617.4, 882.4, 993.5, 1292.7, 1462.6, 1968.2 and 2141.3 μg. h/g for Az drops, Az gel, Az inserts, Az-β-CyD gel, Az-β-CyD inserts, Az-HP-β-CyD gel and Az-HP-β-CyD inserts, resp. The disposition of the drug in eye tissues showed that the distribution was greatly affected by the presence of CyDs. Moreover, the uptake of Az by different eye tissues was quite different from the selected formulations.
2002
12
31
181
188
https://bpsa.journals.ekb.eg/article_65697_260248ba47eba83e48aa0b04d251906b.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
Phytochemical and pharmacological studies on Pulicaria orientalis Jaub & Sp.
Zedan
Ibraheim
Hatem
Salem
The alc. ext. of the aerial parts of Pulicaria orientalis Jaub & Sp. (Arabic name Arar) growing in Saudi Arabia and its chloroform and Et acetate fractions were subjected to preliminary hypoglycemic and anti-inflammatory screening. The total alc. ext. and its chloroform and Et acetate fractions showed a significant hypoglycemic effect in normal and glucose-loaded animals and a significant anti-inflammatory activity using formalin-induced edema. From the pharmacol. active chloroform fraction of the total alc. ext. of the dried aerial part of Pulicaria orientalis six flavonoidal compds. were isolated and identified as kaempferol 3,7-di-Me ether, kaempferol 3-Me ether, quercetin-3-Me ether, 2R,3R-dihydrokaempferol, kaempferol and quercetin in addn. to β-sitosterol and β-sitosterol glucoside. Only one major compd. was isolated from the Et acetate fraction and identified as quercetin-3-O-β-D-glucoside.
2002
12
31
189
200
https://bpsa.journals.ekb.eg/article_65699_187706871b5fa63c31f3ef096a733797.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
Determination of critical micelle concentration (CMC) of different pluronics with two different methods
M.
El-Badry
Rolf
Schubert
Pluronics are series of closely related block copolymers of ethylene oxide and propylene oxide and are used primarily in pharmaceutical formulation as emulsifying or solubilizing agents. In this study, the crit. micelle concn. (CMC) of different pluronics such as L61, L62, L63, L64, L92, F38, and F68 was measured by two different methods. The first method is the surface tension method (ring method); the second one is fluorimetrical method by using DPH (1,6 di-Ph hexatriene). It was found that, by increasing the lipophilicity of the block copolymer (increase the propylene oxide moiety) the CMC value increases. Also, the fluorimetric method is very sensitive, accurate and more reproducible than surface tension method.
2002
12
31
201
205
https://bpsa.journals.ekb.eg/article_65701_3c2a63a8d2b76d41b289833af70f38a0.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
PHYTOCHEMICAL AND BIOLOGICAL STUDIES ON THE LEAVES OF TECOMA MOLLIS HUMB. AND BONPL CULTIVATED IN EGYPT
Nasr
A. El-Emary
Azza
A. Khalifa
Enaam
Y. Backheet
Wael
M. Abdel-Mageed
a-Amyrin (1), 3-b-hydroxy-urs-12-ene-28-aldehyde (2) b-sitosterol (3), ursolic acid lactone (4), ursolic acid (5), 2-b,3-b,19-a-trihydroxy-urs-12-ene-28-oic acid (2-tormentic acid) (6), b-sitosterol-3-O-b-D-glucoside (7) apigenin-7-O-a-L-rhamnoside (8), apigenin-7-O-rutinoside (9), luteolin-7-O-rutinoside (10) and apigenin-6,8-di-C-b-D-glucopyranoside (Vicenin 2) (11) were isolated for the first time from the ethanolic extract of the leaves of Tecoma mollis Humb and Bonpl. cultivated in Egypt. Identification of these compounds has been established by physical and spectral data (UV, IR, MS, 1H- and 13C-NMR) as well as by comparison with authentic samples. Moreover, the biological screening showed that the non-polar fraction of the alcoholic extract (n-hexane, chloroform), polar fraction (ethyl acetate, n-butanol) and aqueous extract as well as ursolic acid possess significant anti-inflammatory, analgesic and antipyretic activities. In addition, the polar fraction and aqueous extract possess also a significant anticonvulsant activity.
2002
12
31
207
228
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
Phytochemical and biological studies on the leaves of Tecoma mollis Humb. And Bonpl cultivated in Egypt
Nasr
El-Emary
Azza
Khalifa
Enaam
Backheet
Wael
Abdel-Mageed
α-Amyrin, 3-β-hydroxy-urs-12-ene-28-aldehyde, β-sitosterol, ursolic acid lactone, ursolic acid, 2-β,3-,β,19-α-trihydroxy-urs-12-ene-28-oic acid (2-tormentic acid), β-sitosterol-3-O-β-D-glucoside, apigenin-7-O-α-L-rhamnoside, apigenin-7-O-rutinoside, luteolin-7-O-rutinoside, and apigenin-6,8-di-C-β-D-glucopyranoside (vicenin 2) (11) were isolated for the first time fron an ethanolic ext. of the leaves of Tecoma mollis Humb and Bonpl. cultivated in Egypt. Identification of these compds. has been established by phys. and spectral data (UV, IR, MS, 1H- and 13C-NMR) as well as by comparison with authentic samples. Moreover, the biol. screening showed that the non polar fraction of the alc. ext. (n-hexane, chloroform), polar fraction (Et acetate, n-butanol) and aq. ext. as well as ursolic acid possess significant anti-inflammatory, analgesic and antipyretic activities. In addn., the polar fraction and aq. ext. possess also a significant anticonvulsant activity.
2002
12
31
297
228
https://bpsa.journals.ekb.eg/article_65703_27203e5834ad3f1265db180c12819734.pdf
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
1110-0052
2002
25
2
Preparation and in-vitro evaluation of alginate beads of flurbiprofen
G.
El-Gindy
The purpose of this study was to prep. and evaluate alginate gel beads as an oral controlled release system of flurbiprofen (FLUP). FLUP is one of the potent nonsteroidal antiinflammatory drugs (NSAIDs) which has deleterious side effects on the GIT such as irritation, ulceration and hemorrhage. The release of FLUP from alginate beads was strongly affected by pH of the dissoln. medium and drug : polymer ratio. In all cases the drug release front alginate beads showed nearly zero-order mechanism. The release rate of drug was more rapidly in alk. medium (pH 7.4) than that at pH 5.8. The swelling property of dried alginate beads was of interest. The beads remained unchanged in acidic medium (pH 1.2 and 5.8) but swelled rather rapidly in pH 7.4 phosphate buffer to a size greater than their original size before being dried. Such a pH-sensitive swelling properties could be advantageous for orally administered drug vehicles, esp. when an acid-sensitive drug or drug that has adverse-effects on the GIT is incorporated in the beads. The effect of the intact drug as well as FLUP alginate beads on the ulcerogenic activity of the drug in the stomach of rabbit was carried out. It was obsd. that, the ulcerogenic activity of the intact drug disappeared and the mucosal surface did not show hemorrhage or inflammation when the drug is loaded with alginate beads.
2002
12
31
229
238
https://bpsa.journals.ekb.eg/article_65706_09895d6f07f0944fc6cb07c83ac6011e.pdf