Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
15
1
1992
12
31
SPECTROCOLOURIMETRIC DETERMINATION OF FURANOCHROMONES AND FURANOCOUMARINS IN PHARMACEUTICAL PREPARATIONS
1
8
70207
10.21608/bfsa.1992.70207
EN
I. S.
Zalat
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt
S. M. I.
Moustafa
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt
I. M.
Elshami
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt
M. M.
El-Olemy
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt
Journal Article
1990
11
08
<em>A colourimetric method based on the reaction of khellin, visnagin and ammidin (imperatorin) with aromatic aldhydes in acid media was developed. The colour obtained was used for the determination of ammidin and furanochromones in pharmaceutical preparations. The optimum conditions for colour production and stability were determined, Beer's Lambert's law was obeyed over the concentration range of 4-10 </em><em>m</em><em>cg/ml of each of khellin and visnagin and 4-60 </em><em>m</em><em>cg/ml for ammidin. The proposed method compared favourably with other reported methods.</em>
https://bpsa.journals.ekb.eg/article_70207_ceb4fd85e973aafcdbbc123e3456ea58.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
15
1
1992
12
31
SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN IMIDAZO[4,5-b]PYRIDINES
9
21
70208
10.21608/bfsa.1992.70208
EN
M. A.
El-Gendy
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
H. H.
Farag
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. N.
Abmed
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
J. R.
Stedman
School of Pharmacy, Temple University, Philadelphia, USA
G. S.
Alkaramany
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1990
12
16
<em>The synthesis of certain imidazo[4,5-b]pyridine derivatives namely;3-(p-(un)substitutedphenacyl) imidazo[4,5-b]pyridin-2-ones, their ketoximes and 1,3-bis(p-(un)substitutedphenacyl)imidazo[4,5-b]pyridin-2-ones, were under-taken. In addition the synthesis of a series of 2-methylaminoimidazo[4,5-b]pyridines and their corresponding ketoximes are discussed. Some of the synthesized imidazo[4,5-b]-pyridin-2-ones derivatives showed reasonable analgesic activity in comparison to Aspirin and Indomethacin. Compounds of 2-methylaminoimidazo [4,5-b] pyridines and their corresponding ketoximes have been tested for their anthelmintic activity against Ascaris Vitulorum of cattle in comparison to Mebendazole.</em>
https://bpsa.journals.ekb.eg/article_70208_87595a2141288905ed537479efaef690.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
15
1
1992
12
31
A PRELIMINARY INVESTIGATION OF FLAVANOLIGNANS OF SILYBUM MARIANUM (L) GEARTN FRUITS GROWING IN EGYPT
22
26
70209
10.21608/bfsa.1992.70209
EN
L.
Dranik
All-Union Research Institute of Drug Chemistry and Technology, Kharkov, USSR
L.
Dolganenko
All-Union Research Institute of Drug Chemistry and Technology, Kharkov, USSR
A.
Grysodub
All-Union Research Institute of Drug Chemistry and Technology, Kharkov, USSR
M.
Levin
All-Union Research Institute of Drug Chemistry and Technology, Kharkov, USSR
I. M.
Eshami
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt
Journal Article
1991
04
25
<em>The flavanolignans of the fruits were isolated by column chromatography and identified by TLC and HPLC in addition to m.p., ms, uv and optical rotation measurements. A comparative study by TLC and HPLC of the flavanolignans from the purple flowered and the white-flowered plants of Silybum marianum was performed. The major flavanolignans of the white flowered plants were identified as silybin, silychristin, silydianin and taxipholin. The major flovanolignans of purple-f lowered plants were found to be silybin, silichristin and taxipholin.</em>
https://bpsa.journals.ekb.eg/article_70209_36cd6569fb2afa7298146f1b9d04cdc1.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
15
1
1992
12
31
A CONTRIBUTION TO THE INTERACTION BETWEEN CHLORAMPHENICOL AND NONIONIC SURFACTANTS
27
36
70213
10.21608/bfsa.1992.70213
EN
S.
Ismail
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut Egypt
F. S.
Habib
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut Egypt
S.
Elshanawany
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut Egypt
E. A.
Fouad
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut Egypt
Journal Article
1991
05
12
<em>The interaction between chloramphenicol and some nonionic surfactants has been investigated using both the dynamic and equilibrium dialysis techniques. The surfactants tested were Tweens, Myrjs and Brijs. The permeation of chloramphenicol across a standard cellophane membrane either in absence or presence of increasing concentrations of those surfactants was found to follow first order kinetics. The data revealed that, the presence of nonionic surfactants resulted in a reduction of the corresponding permeation rate constant. The extent of reduction was parallel to the surfactant concentration. The antimicrobial activity of chloramphenicol against B. subtilis (ATTC 663) was examined in presence of these nonionic surfactants. The data revealed that the presence of those surfactants has insignificantly affected the antimicrobial activity of chloramphenicol especially when they were used in concentrations above their respective CMC values.</em>
https://bpsa.journals.ekb.eg/article_70213_f55c4aacc1d1a254a03cdedb3677e708.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
15
1
1992
12
31
EFFECT OF CERTAIN MACROMOLECULES ON THE EXTRACTION OF SOPHORA ALKALOIDS
37
48
70214
10.21608/bfsa.1992.70214
EN
Aly A.
Abdel Rahman
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Afaf M.
Abdel Baky
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1991
09
03
<em>Sophora matrine alkaloids have recently been useful in the treatment of some types of cancer. </em>
<em>Certain classes of macromolecules including non-ionic surfactants, polyethylene glycols and cyclodextrins have been investigated for their effects on the extraction of Sophora alkaloids from the,leaf, the bark and the seed.</em>
<em>Increasing the non-ionic surfactant solutions above CMC improved the yield of the extracted alkaloids calculated and quantified after TLC separation as cytisine. Extending the hydrocarbon chain in a homologous series of non-ionic surfactants containing the same polyoxyethylene chain improved the extraction from the leaf, the bark and the seed and vice versa. That is why polysorbate 80 is more efficient than ploysorbate 20 and Brij 58 is more efficient than Brij 35. On the otherhand Eumulgin C 1500 is less efficient than Eumulgin C 1000 and Myrj 59 is less efficient than Myrj 53.</em>
<em>PEGs improved the extraction of Sophora leaf alkaloids irrespective of the concentration. Increasing the molecular weight of PEGs leads to decrease in the yield of cytosine extracted from the leaf.</em>
<em>Cyclodextrins improved the yield of cytisine extracted from Sophora leaf. It was found that </em><em>b</em><em>-cyclodextrin is more effective than </em><em>a</em><em>-cyclodextrin in this concern. In both cases the inclusion isotherm was found to be A<sub>N</sub> type with no precipitation of the inclusion compound.</em>
https://bpsa.journals.ekb.eg/article_70214_3c01dfe7a97cfe5c5f42e7c81f1e2319.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
15
1
1992
12
31
PREPARATION AND EVALUATION OF CLONAZEPAM SOLID DISPERSIONS
49
56
70215
10.21608/bfsa.1992.70215
EN
A. A.
Abdel Rahman
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S. I.
Saleh
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S. M.
Ahmed
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
G. M.
Mahrous
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1991
10
08
<em>Preparation of clonazepam solid dispersions was carried out using certain hydrophilic carriers including polyethylene glycol 2000, (PEG 2000) polyethylene glycol 4000 (PEG 4000), polyethylene glycol 6000 (PEG 6000), polyvinyl pyrrolidone 44000 (PVP 44000), Myrj 52, Myrj 53 and Myrj 59.</em>
<em>The solvent method was adopted for the preparation of the investigated solid dispersions which were subjected to ultraviolet, differential scanning calorimetry (DSC) and dissolution evaluation. It was found that dissolution enhancement was obtained from the prepared co-precipitates compared to the drug alone. The type of the carriers used, their chemical natures and their molecular weights have pronounced effects on the dissolution rate of the drug.</em>
https://bpsa.journals.ekb.eg/article_70215_7c161f97eedd7cd1f42b7390ab9898cf.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
15
1
1992
12
31
EVALUATION OF TABLETED CINNARIZINE-MICROCRYSTALLINE CELLULOSE GROUND MIXTURE
57
62
70216
10.21608/bfsa.1992.70216
EN
S. M.
Ahmed
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S. I.
Saleh
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. E.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1991
11
23
<em>Fast release cinnarizine (CN) tablets were prepared by the direct compression of CN-microcrytalline cellulose (1:3) ground mixture. Directly compressed tablets containing either untreated CN or ground CN were also prepared for comparison. Avicel PH 101 was used as the direct compression excipient in each case. The produced tablets were evaluated with regard to their dissolution characteristics, their drug content uniformity and their physical properties including uniformity of weight, hardness, friability and disintegration time. Tablets compressed containing CN-microcrystalline cellulose ground mixture showed good physical properties, better drug content uniformity and superior dissolution characteristics compared to the tablets containing untreated or ground alone CN.</em>
https://bpsa.journals.ekb.eg/article_70216_1d932d64d6e5b61116b19e71ea550102.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
15
1
1992
12
31
OPTIMIZATION OF EUDRAGIT OR CELLULOSIC POLYMERS-IBUPROFEN SUSTAINED RELEASE SYSTEMS USING PRINCIPAL COMPONENT ANALYSIS
63
82
70217
10.21608/bfsa.1992.70217
EN
Aly A.
Abdel Rahman
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. E.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
Stamm
Faculty of Pharmacy, Louis Pasteur University, France
S. I.
Abdel Rahman
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
E. M.
Samy
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1992
02
16
<em>In order to retard the release of ibuprofen from its prepared tablets Eudragit polymers including Eudragit L100, Eudragit RS, Eudragit RLPM and Eudragit RSPM as well as cellulosic polymers including ethyl cellulose 20, hydroxyl propyl-methyl cellulose 606 (Pharmacoat 606) and hydroxyl propyl-methyl cellulose phthalate 55 (HP 55 f) have been used as granulating agents and excipients. The principal component analysis helped to investigate 13 variables on 23 formulae (ibuprofen granulated with Eudragit polymers) and 10 variables on 31 formulae (ibuprofen granulated with cellulosic polymers). It was possible by this method to represent all the relations existing between the 13 and 10 variables on simple circles of correlations. These variables include: concentration of the drug, concentration of the polymer, dissolution of the drug at pH 1.5 and pH 7.5, the tablet breaking strength, the tablet friability, the tablet hardness/friability ratio, the time of 50 and 80% drug release, the drug release rate constant of first order kinetic at pH 1</em><em>.</em><em>5 and pH 7.5, the drug release rate constant of Higuchi equation and dissolution efficiency.</em>
<em>Principal component analysis allowed to separate the formulae according to their compression characteristics, the dissolution efficiency, the kinetic parameters, the quality and the best choosing polymer for the retardation of ibuprofen and choosing the preferable excipient for the sustained release formulations. Dissolution was identified as the predominant parameter of the system next by compression characte</em><em>r</em><em>istics.</em>
<em>From the principal component analysis investigations, it could be concluded that the formula of ibuprofen granulated with 15% Eudragit RSPM and containing 23% Avicel pH 102 and the formula granulated with 3% ethyl cellulose 20 and containing 23% Avicel pH 102 were found to be the optimum formulae.</em>
https://bpsa.journals.ekb.eg/article_70217_7a3a18f31bd7607187a6513d6bff34f2.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
15
1
1992
12
31
SYNTHESIS OF CERTAIN 8-[2-HYDROXY-3-(SUBSTITUTEDAMINO)PROPOXY]QUINOLINES AS B-ADRENERGIC BLOCKING AGENTS
83
88
70218
10.21608/bfsa.1992.70218
EN
Abd-El Hamid N.
Ahmed
Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1992
02
25
<em>The reaction of 8-hydroxyquinoline <strong>I</strong> with epichlorohydrin in the presence of potassium carbonate yielded a mixture of the epoxide <strong>II</strong> and the chlorohydrin III. The reaction of certain amines with a mixture of <strong>II</strong> and <strong>III</strong> afforded 8-[2-hydroxy-3-(substitutedamino) propoxy] quinoline <strong>IVa-h</strong>. The structure of the synthesized compounds was established by microanalyses and <sup>1</sup>H-NMR spectra. The hydrolytic rate constants in aqueous solution at pH 7 and pH 12 were determined using HPLC technique.</em>
https://bpsa.journals.ekb.eg/article_70218_ab18a3d86186ab55a6008988ca3555a3.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
15
1
1992
12
31
EFFECT OF CELLULOSIC POLYMERS ON THE PHYSICAL PROPERTIES AND DISSOLUTION OF IBUPROFEN GRANULES
89
99
70219
10.21608/bfsa.1992.70219
EN
Aly A.
Abdel Rahman
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. E.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
Stamm
Faculty of Pharmacy, Louis Pasteur University, France
S. I.
Abdel Rahman
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
E. M.
Samy
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1992
07
15
<em>Ibuprofen sustained release granules were prepared using ce11ulosic polymers including, ethy1cel1u1ose 20, hydroxypropyl methyl cellulose (Pharmacoat 606) and hydroxypropyl methy1 cellulose phthalate (HP 55 F). Polyvinyl pyrro1idone (PVP) was used also as a granu1ating agent for comparison.</em>
<em>Increasing the concentration of the granulating agents investigated lead to retardation of the drug release rate except for Pharmacoat 606. Ethyl cellulose 20 in 5% w/v concentration proved to be the best retardant for ibuprofen release rate from the prepared granules.</em>
<em>The physical properties of ibuprofen powder, ibuprofen granules as a control and ibuprofen granules granulated with 5% w/v ethyl cellulose 20 were examined and including the size range, the angle of repose, the flow rate, the bulk density, the Hausner factor, the compressibi1ity, the friability and the parameters of Kawakita.</em>
<em>The effect of particle size of ibuprofen granules prepared by 5% w/v ethyl cellulose 20 as a granulating agent was checked. Increasing the particle size of the prepared granules lead to more prolongation in ibuprofen release rate.</em>
https://bpsa.journals.ekb.eg/article_70219_6551d238b1ce035260d98b7f5b90a5f7.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
15
1
1992
12
31
1HNMR OF PYRAZOLES: EFFECT OF INTERACTION OF CARBAMOYL GROUP WITH ADJACENT CENTERS ON THE CHEMICAL SHIFTS OF CONCERNED PROTONS
100
105
70220
10.21608/bfsa.1992.70220
EN
Tarek A.
Mohamed
Department of Medicinal Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71516, A.R. Egypt
Adel F.
Youssef
Department of Medicinal Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71516, A.R. Egypt
Abd-El-Hamid N.
Ahmed
Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71516, A.R. Egypt
Journal Article
1992
08
17
<em>The <sup>1</sup>HNMR of a series of constitutional isomers of dimethylpyrazole carboxamides revealed the contribution of </em><em>p</em><em> and/or n-electrons in deshielding protons </em><em>a</em><em>- to CONHR group. Intermolecular hydrogen bonding with polar solvent molecules was able to affect more strongly the CONHR proton chemical shift than intramolecular. The observed pattern of </em><em>d</em><em> values shown by CONHR proton in the derivative R= C6H11 allowed to assign for it a trans axial conformation. Finally a regression equation was derived to draw a linear relation between the chemical shifts of CONHR protons in both isomers.</em>
https://bpsa.journals.ekb.eg/article_70220_9c677d0ca9f8282bbca86000e3b21aeb.pdf