Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
41
1
2018
12
31
MACRO- AND MICROMORPHOLOGY OF THE LEAF, STEM, STEM BARK AND FRUIT OF FAIDHERBIA ALBIDA (DEL.) A. CHEV. CULTIVATED IN EGYPT
1
29
62461
10.21608/bfsa.2018.62461
EN
Marwa M.
Mohammed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Ahmed A.
Ali
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Ezz-eldin K.
Desoky
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Lourin G.
Gobraeil
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
2017
08
06
<em>The trees of Faidherbia albida Del. are indigenous to Africa and considered a prominent feature in the flora of Nile valley and the Eastern Desert. They are known as Apple-ring trees because the pods tend to roll in to a spirals resembling dried apple peal. It is employed traditionally to treat disorders such as fever, diarrhoea, urticaria, vomiting, cough, rheumatism and haemorrhage. To our knowledge, few morphological and microscopical studies were traced concerning the plant</em><em><sup>1</sup></em><em>, so this study aims for characterization and identification of this plant in both entire and powdered forms.</em>
https://bpsa.journals.ekb.eg/article_62461_b98bb3ab13fd07328980a8ab0b80d45a.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
41
1
2018
12
31
FORMULATION OF 5-FLUOROURACIL MICROSPONGES AS COLON TARGETED DELIVERY SYSTEM USING 32 FACTORIAL DESIGN
31
44
62464
10.21608/bfsa.2018.62464
EN
Ahmed U.
Ali
Department of Pharmaceutics, Faculty of Pharmacy, Asyut University, Asyut 71526, Egypt
Mahmoud
El-Badry
Department of Pharmaceutics, Faculty of Pharmacy, Asyut University, Asyut 71526, Egypt
Tahani H.
Elfaham
Department of Pharmaceutics, Faculty of Pharmacy, Asyut University, Asyut 71526, Egypt
Journal Article
2017
12
11
<em>5-Fluorouracil is widely used for treatment of colorectal cancer and is provided as intravenous bolus or infusion because it has erratic oral bioavailability. Diarrhea and myelosuppression are potential and the major side effects of the intravenous administration route. This work was aimed to develop colon-targeted delivery of 5-Fluorouracil microsponges so that, the oral bioavailability enhanced and the side effects could be potentially reduced. Quassi-emulsion solvent diffusion method was used to prepare 5-Fluorouracil microsponges using polyethylene glycol as an emulsifier. Different formulae were prepared with different composition and processing factors. The entrapment efficiency 5-Fluorouracil in these formulae ranged from 17.81 to 78.61%, the particle size of the prepared microsponges ranged from 87 to 229 µm and the % cumulative drug released after 24 hours ranged from 47.7 to 98.58%. The prepared microsponges were subjected to compatibility studies as Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Thus 5-fluorouracil microsponges considered as a promising system for the colon-specific delivery that has potential for future use as an anticancer therapy for colorectal cancer.</em>
https://bpsa.journals.ekb.eg/article_62464_bd92a7d7d6e6e2744b425491924ccccb.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
41
1
2018
12
31
NARINGIN PREVENT CISPLATIN-INDUCED NEPHROTOXICITY BY ABROGATION OF OXIDATIVE STRESS AND INFLAMMATION IN RATS
45
54
62467
10.21608/bfsa.2018.62467
EN
Abd-Elmoniem A.
Taha
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt
M. M.A.
Khalifa
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Egypt
Mohamed I.
Abd El-Salam
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt
Journal Article
2018
04
26
<em>Nephrotoxicity remains one of the most dangerous effect relevant to cisplatin use in chemotherapy. Rat injection with cisplatin in a single dose of 7 mg/kg intraperitoneally resulted in a significant increase in serum level of urea and creatinine. Also, cisplatin caused marked increase in renal content of malondialdehyde (MDA), while depletion in reduced glutathione (GSH). In addition, cisplatin administration notably increased kidney/body weight ratio, renal contents of nitric oxide (NO), tumor necrosis factor alpha(TNF-α) and cyclooxygenase-2 (COX-2) protein level as well as renal myeloperoxidase (MPO) activity. Histopathological examination confirmed the biochemical and molecular results which revealed several pathological alteration in the renal tissues following cisplatin. Oral pretreatment of rats with naringin (NAR) (80 mg/kg) for 14 days before and 7 days after cisplatin injection significantly reduced the pathological level of serum urea and creatinine and restored oxidative stress parameters. In the same manner, the inflammatory markers as well as kidney/body weight ratio show great improvement following the treatment. The histopathological examination confirms fit with the biochemical and molecular results. In conclusion, NAR showed a great protective effect against cisplatin-induced nephrotoxicity in rats via its antioxidant, anti-inflammatory roles. </em>
https://bpsa.journals.ekb.eg/article_62467_c1843fc8d01797198eacf16b6ac2655b.pdf
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
41
1
2018
12
31
BOTANICAL PROFILING OF GMELINA PHILIPPENSIS CHAM., CULTIVATED IN EGYPT
55
80
62468
10.21608/bfsa.2018.62468
EN
Hanaa M.
Sayed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Amany S.
Ahmed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Iman S.A.
Khallaf
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
Asem
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
2018
05
09
<em>Gmelina philippensis Cham. Family Lamiaceae, sometimes placed in family Verbenaceae, is one of the ornamental and medicinal plants, known as parrot’s peak, as it produces yellow flowers from a long tube-shaped structure comprised of overlapping bracts. It is a sprawling thorny shrub that was formerly taxonomically classified to family Verbenaceae. It is native to Philippines, Burma and distributed in tropical and subtropical countries. The present investigation attempts to study the pharmacognostical features of the aerial parts (leaves, stems and inflorescence) of Gmelina philippensis Cham. which could be helpful in authentication of the plant and establishing pharmacognostical standard measurements which help in its identification in both entire and powdered forms.</em>
https://bpsa.journals.ekb.eg/article_62468_61bf134101801505649c3f250cd8ebbe.pdf