Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
18
2
1995
12
31
3-(ETHOXYCARBONYL)-2-METHYLPYRROLE-5-CARBOXALDEHYDE AS A VERSATILE SYNTHONE FOR POTENTIAL ANTIBACTERIAL AGENTS
59
67
69684
10.21608/bfsa.1995.69684
EN
Hassan M.
Mokhtar
Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
Ola A.
El-Sayed
Department of Botany and Microbiology, Faculty of Science, Alexandria University, Alexandria, Egypt
Azza H.
El-Sabaeny
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
Journal Article
1995
04
17
<em>Reaction of 3-(ethoxycarbonyl)-2-methylpyrrole-5-carboxaldehyde with substituted thiosemicarbazides afforded the corresponding (thiocarbamoyl) hydrazones. The latter compounds underwent cyclization to thiazole, thiazolidinone, thiazinone and thiadizole derivatives under the proper reaction condition. All the prepared compounds were evaluated for this antimicrobial activity.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
18
2
1995
12
31
SYNTHESIS AND PHARMACOLOGICAL TESTING OF SOME NEW DERIVATIVES OF 2,4-(1H,3H)-QUINAZOLINEDIONE (PART II)
69
78
69689
10.21608/bfsa.1995.69689
EN
Abdel Ghany A.
El-Helby
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University,Cairo, Egypt
Journal Article
1995
06
07
<em>A variety of 2,4 (1H, 3H) quinazolinediones were converted into the corresponding potassium salts, and then allowed to react with some halogen-containing compounds. The structures of the derivatives thus prepared, were confirmed by elemental, JR, <sup>1</sup>H-NMR and MS spectral data. Testing for anticonvulsant and hypnotic activities in frogs is also presented.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
18
2
1995
12
31
INVESTIGATION OF THE PROTEIN CONTENT OF EICHHORNIA CRASSIPES (MART.) SOLMS AND PISTIA STRATIOTES L. GROWING IN EGYPT
79
85
69692
10.21608/bfsa.1995.69692
EN
M. S.
Afify
Department of Pharmacognosy, Faculty of Pharmacy, El-Mansoura University, El-Mansoura, Egypt
F. M.
Hashem
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Z. El-Abdin M.
Naeem
Department of Pharmacognosy, Faculty of Pharmacy, El-Mansoura University, El-Mansoura, Egypt
Journal Article
1994
05
09
<em>A qualitative and quantitative study of the protein content of roots, stems and leaves of Eichhornia crassipes (Mart.) Solms (Family: Potederiaceae) and Pistia sratiotes L., (Family: Aracaceae), were carried out. This study revealed that these plants contain a large percent of nutritive proteins which include high percentage of essential amino acids covering the requirements of birds (Turkey) and animals.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
18
2
1995
12
31
SULFATED GLYCOSIDES. STRUCTURAL PROOF FOR SALVADOSIDE THROUGH COMPARISON WITH THAT REGIOSELECTIVELY SYNTHESIZED FROM D-GLUCOSE
87
93
69695
10.21608/bfsa.1995.69695
EN
Mohamed S.
Kamel
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
Abdel-Nasser A.
El-Shorbagi
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
Esko
Karvinen
Department of Organic Chemistry, Faculty of Science, University of Oulu, Oulu, Finland
Ari
Koskinen
Department of Organic Chemistry, Faculty of Science, University of Oulu, Oulu, Finland
Journal Article
1995
09
03
<em>Salvadoside; sodium (1-O-benzyl-</em><em>b</em><em>-D-glucopyranoside-2-sulfate) [<strong>1</strong>], a recently isolated sulfated glycoside from the Egyptian plant Salvadora persica L. used in the treatment of gastritis in folk medicine, has been synthesized in four steps from glucose. The route adopted also allows regioselective synthesis of structural isomers of the target compound.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
18
2
1995
12
31
A PHARMACOGNOSTICAL STUDY OF CERTAIN PAPAVER SPECIES GROWING IN EGYPT. PART I: INVESTIGATION OF THE LIPID CONTENT
95
101
69697
10.21608/bfsa.1995.69697
EN
M. S.
Afifi
Department of Pharmacognosy, Faculty of Pharmacy, El-Mansoura University, El-Mansoura, Egypt
F. M.
Hashem
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
H. A.
Saad
Department of Pharmacognosy, Faculty of Pharmacy, El-Mansoura University, El-Mansoura, Egypt
Journal Article
1994
05
09
<em>A phytochemical study of the lipid content of the leaves, flowers, fruits, stems and roots of Papaver somniferum L. (Family: Papavaraceae), as well as a comparative study of the fixed oil of the seeds of Papaver somniferum L., P. bracteatum Lindl. and P. rhoeas L. growing in Egypt were carried out, using TLC, column chromatography and GLC. The study of the unsaponifiable matters of the different investigated parts of Papaver rhoeas L., revealed the presence of </em><em>a</em><em>-and </em><em>b</em><em>-amyrins, </em><em>b</em><em>-sitosterol, campesterol (not present in seeds) stigmasterol and two saturated aliphatic alcohols. The first is a primary alcohol with an empirical formula C<sub>22</sub>H<sub>46</sub>O, while the second is a secondary alcohol with an empirical formula C<sub>29</sub>H<sub>60</sub>O.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
18
2
1995
12
31
MICROBIAL TRANSFORMATION OF LIPIDS: SELECTIVE HYDRATION OF OLEIC ACID
103
106
69698
10.21608/bfsa.1995.69698
EN
Saleh H.
El-Sharkawy
Department of Pharmacognosy, Faculty of Pharmacy, El-Mansoura University, El-Mansoura, El-Mansoura, Egypt
John P. N.
Rosazza
Center for Biocatalysis, College of Pharmacy, Iowa University, Iowa City, IA 52242 USA
Journal Article
1995
11
07
<em>The cultures Nocardia sp. NRRL 5646, Nocardia aurantia ATCC 12674, and Mycobacterium fortium AM 53378 were identified as being capable of metabolizing oleic acid. These organisms selectively hydrated the cis-double bond of oleic acid in the presence of other fatty acids like oleic : linoleic (1 :1, w/w), oleic : stearic (9:1, w/w), oleic : linoleic : stearic (2:2:1,w/w), and oleic:linoleic: palmitic (2:2:1, w/w). Based on gas chromatography of the fatty acid methyl esters, it was found that stearic, palmitic, and linoleic acids were unreactive with the hydratase enzyme of the three microbes and in all cases 80-88% of oleic acid was consumed. Thus, the hydratase enzyme was able to selectively and quantitatively hydrate oleic acid and discriminate among monoenoic, dienoic and saturated fatty acids. This work provides a mean of oxidatively removing oleic acid from among a mixture of other mono and polyunsaturated vegetable oil fatty acids. We believe that the selected organisms have the abilities to transform oleic acid and to selectively utilize that compound from similar mixtures as well.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
18
2
1995
12
31
SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME QUINAZOLINONE DERIVATIVES
107
114
69699
10.21608/bfsa.1995.69699
EN
Adnan A.
Bekhit
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
Journal Article
1995
08
01
<em>Several quinazolinone compounds were prepared having thiadiazole moiety joined to the 4(3H)-quinazolinone ring at 2-position through thiomethyl bridge. The antimicrobial activities of the prepared compounds have been investigated.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
18
2
1995
12
31
SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME PYRROLE DERIVATIVES
115
123
69700
10.21608/bfsa.1995.69700
EN
Ola A.
El-Sayed
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
Hassan M.
Mokhtar
Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
Hoda
El-Shamy
Department of Microbiology, High Institute of Public Health, Alexandria University, Alexandria, Egypt
Journal Article
1995
09
24
<em>Several derivatives have been built up from 3-(ethoxy-carbonyl)-2-methylpyrrole-5-carboxaldehyde. Furthermore, pyrrole-pyrazole derivatives have also been prepared and the antimicrobial activity of all the prepared compounds is reported.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
18
2
1995
12
31
PREPARATION AND EVALUATION OF PHENYLTOLOXAMINE CITRATE MICROSPHERES
125
134
69704
10.21608/bfsa.1995.69704
EN
E. M.
Samy
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
F. A.
Mohamed
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. S.
Ali
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M. M.
Anwar
Department of Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt
A. E.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1995
08
26
<em>Microspheres of phenyltoloxamine citrate (PTC) with cellulose acetate butyrate (CAB) were prepared using an emulsion-solvent evaporation technique. Good reproducibility in microspheres preparation was observed. The recovery of drug from different microspheres varied between 87 and 94 %. The release rates of the drug from these microsphres were decreased as compared with that from the drug powder. Different release characteristics were obtained by changing the drug-to-polymer ratio and varying the particle size of micro spheres. As the polymer to drug ratio increased, the microsphere size distribution shifted to the smaller size and the release of the drug decreased. The release of the drug showed pH-dependence. The release kinetics of the drug from CAB microspheres were studied. The antihistamine and the analgesic activities of PTC alone and PTC microspheres were evaluated in vivo. The antihistamine and analgesic activities of the tested microspheres in vivo were found to be greater and more prolonged than that of the intact drug.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
18
2
1995
12
31
HAEMATOXYLIN-PERMANGANATE REAGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF SOME THIOL DRUGS
135
141
69706
10.21608/bfsa.1995.69706
EN
Ibrahim H.
Refaat
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1995
08
03
<em>A new rapid and sensitive spectrophotometric method was developed for the determination of six thiol pharmaceutical compounds. The method is based on the spontaneous oxidation of the thiol group with a constant small concentration of potassium permanganate followed by the rapid reaction of the excess permanganate with haematoxylin reagent in neutral aqueous medium. Haematoxylin is oxidized to the coloured chromogen, haematein which was measured at 558 nm. A linear relationship was obtained between drug concentration and the decrease in absorbance readings. The method was applied for the determination of the investigated compounds either in authentic powders or in some .dosage forms. Good agreement was obtained with the reported methods. In addition, the suggested method was tried as stability indicating assay for the investigated thiol drugs.</em>