Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
12
2
1989
12
31
INTERACTION OF TEMAZEPAM WITH HYDROPHILIC MACROMOLECULES VI- PREPARATION, DISSOLUTION CHARACTERISTICS AND AGEING OF TEMAZEPAM SOLID DISPERSIONS
175
194
72053
10.21608/bfsa.1989.72053
EN
A. A.
Abdel Rahman
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. E.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
B. A.
Mulley
School of Pharmacy, Bradford University, England
S. M.
Ahmed
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1989
02
06
<em>Temazepam solid dispersions were prepared using the solvent and the fusion methods with certain hydrophilic carriers including polyethylene glycol 6000 (PEG 6000),Murj 52, polyvinyl pyrrolidone 10000 (PVP 10000), and polyvinyl pyrrolidone 40000 (PVP 40000).</em>
<em>It was found that the solvent method is preferable than the fusion method.</em>
<em> Thin layer chromatographic investigations revealed that three was no chemical degradation of the drug or the carriers through processing.</em>
<em> Infrared analysis revealed that there was no evidence for complexation between temazepam and the investigated carriers nor decomposition of the drug.</em>
<em> Differential scanning calorimetery (DSC) investigations illustrated that the drug present in the coprecipitates in the amorphous form in the fresh samples as well as the aged-ones. HPLC in the aged samples proved no drug degradation.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
12
2
1989
12
31
PHYTOCHEMICAL STUDY OF CASSIA DIDYMOBOTRYA FRES. CULTIVATED IN EGYPT. PART II: FLAVONOIDS AND STEROLS
195
212
72054
10.21608/bfsa.1989.72054
EN
S. M.
El-Sayyad
Department of Phannacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. M.
Abdel-Baky
Department of Phannacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
E. Y.
Backheet
Department of Phannacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
K. W.
Glombitza
Institut, fur Pharmazeutische, Biologie dier Universität Bonn, West Germany
Journal Article
1989
04
05
<em>From the air-dried powdered leaves, stems, flowers and fruits of </em><em>Cassia didymobotrya</em><em> fres. The following compounds were isolated for the first time; isorhamnetin-3-O-glucoside, isorhamnetin-7-O-glucoside, isorhamnetin-3-O-rhamnosyl-O-glucoside, kaempferol-7-O-rhamnosyl-O-glucoside, kaempferol-3-O-rhamnosyl-O-glucoside, stigmasterol and its 3-O-glucoside. In addition kaempferol and quercetin were isolated. All compounds were identified by comprehensive spectral analysis.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
12
2
1989
12
31
MACRO AND MICROMORPHOLOGY OF CASSIA SPECTABILIS. DC. CULTIVATED IN EGYPT PART II. THE FLOWER, FRUIT AND SEED
213
239
72056
10.21608/bfsa.1989.72056
EN
S. M.
El-Sayyad
Department of Pharmacognosy, Faculty of Pharmacy , Assiut University, Assiut, Egypt
A. M.
Abdel-Baky
Department of Pharmacognosy, Faculty of Pharmacy , Assiut University, Assiut, Egypt
M. A.
El-Shanawany
Department of Pharmacognosy, Faculty of Pharmacy , Assiut University, Assiut, Egypt
Kh. M.
El-Ghondakly
Department of Pharmacognosy, Faculty of Pharmacy , Assiut University, Assiut, Egypt
Journal Article
1989
04
15
<em>The macro and micromorphology of the flower, fruit and seed of Cassia spectabilis DC. cultivated in Egypt</em><em> have been investigated in order to determine the diagnostic features by which each organ could be identified both in the entire and powdered form.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
12
2
1989
12
31
FORMULATION OF CONTROLLED-RELEASE IBUPROFEN GRANULES AND EVALUATION OF THE ANTIINFLAMMATORY ANALGESIC ACTIVITIES
240
265
72057
10.21608/bfsa.1989.72057
EN
S.
Safwat
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S.
El-Shanawany
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M. M.
Abdel-Rahman
Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt
S. A.
Mangoura
Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt
Journal Article
1989
05
09
<em>Two kinds of granules were prepared: one. with pH-dependent Release and the other with pH-in dependent release. The former was composed of ibuprofen, celluloseacetate phthalate, ethylcellulose and microcrystalline cellulose while the latter was composed of ibuprofen, hydroxypropyl methylcellulose</em><em>, </em><em>ethylcellulose</em><em> and corn starch. The effects of mixing ratios of the polymers; pH of the release medium, and the drug content in the granules were examined in-vitro to investigate the release characteristics. In granules with pH-dependent, the release rate was decreased with the increment of </em><em>ethylcellulose</em><em> and as the pH of the release medium increased. While in granules with pH-independent, the release rate was decreased as the ratio of hydroxypropyl methylcellulose (HPMC) to </em><em>ethylcellulose</em><em> (EC) increased Analgesic activity of four seleted formulations of the controlled release was tested by two methods using p-benzoquinone (PB2) induced withing and the hot-plate. Also the anti-inflammatory activity of these formulations was examined after oral administration of the granules by using trypan-blue dye method. Results that the formulation of ibuprofen granules pH-independent containing HPMC and EC revealed in ratio of 3:1 had a delayed onset of anti-inflammatory and analgesic action extended for four hours or more while granules of ibuprofen with pH-dependent containing 4% ethylcellulose and 2% cellulose acetate phthalate were capable of increasing analgesic against thermal stimuli for four hours whereas lower percentage protection against PBO-induced wrifhing, was observed. Statistical analysis of the results were done using student's t-test.</em>
<em> The pH- independent release granules were superior to the pH-dependent release granules with respect to prolonging the effective antiinflammatory action when administered orally to rats.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
12
2
1989
12
31
FURTHER NEW ALKALOIDS FROM CASSIA SIAMEA LAM. LEAVES
266
272
72058
10.21608/bfsa.1989.72058
EN
S. M.
El-Sayyad
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
H. M.
Sayed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S. A.
Ross
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1989
06
10
<em>Two new isoquinolone alkaloids were isolated from the leaves of Cassia siamea Lam. and their structureswere designated as 8-acetyl siamine and 3,8-dimethyl-6,7-methylene dioxy isoquinolone.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
12
2
1989
12
31
DEMETHYL LEPIDINE, A NEW ALKALOID FROM LEPIDIUM SATIVUM SEEDS
273
281
72059
10.21608/bfsa.1989.72059
EN
A. A.
Ali
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
H. M.
Sayed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
O. M.
Abdalla
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
W.
Steglish
Institute fur Organische Chemie und Biochemie der Universität, Bonn, West Germany
Journal Article
1989
07
01
<em>Two imidazole alkaloids (I&II) have been isolated from the seeds of Lepidium sativum L. Compound <strong>I</strong> O-demethyllepidine was isolated for the first time and its structure was elucidated on the basis of spectral analysis, while compound <strong>II</strong> was identified as lepidine and its identification was confirmed by X-ray crystallography.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
12
2
1989
12
31
MACRO-AND MICROMORPHOLOGY OF TABEBUIA GUAYACAN HEMSL CULTIVATED IN EGYPT PART I: THE STEM AND LEAF
282
297
72060
10.21608/bfsa.1989.72060
EN
M. A.
Makboul
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1989
09
05
<em>The macro-and micromorphology of the stem and leaf of Tabebuia guayacan Hemsl cultivated in Egypt at Aswan Botanic garden have been investigated in order to determine the diagnostic features by which each could be identified in the entire and powdered forms. </em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
12
2
1989
12
31
1H-NUCLEAR MAGNETIC RESONANCE (NMR) STUDY OF PIROXICAM-CYCLODEXTRINS INCLUSION COMPLEXES
298
307
72061
10.21608/bfsa.1989.72061
EN
N. M.
Omar
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. N.
Ahmed
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
H.
Ueda
Hoshi Institute of Pharmaceutical Sciences, Tokyo, Japan
S. M.
El-Gizawy
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1989
09
12
<em>A structural study of the inclusion compounds of piroxicam with cyclodextrins (</em><em>a</em><em>-, </em><em>b</em><em>- and </em><em>g</em><em>-) in different molar ratios was studied by means of <sup>1</sup>H-nuclear magnetic resonance (NMR) spectroscopy. The change in the chemical shift suggested that the drug pyridine moity was included in the cavity of cyclodextrins and most of the protons shifted to lower field with increasing the concentration of cyclodextrins. Plots of the molar ratio of cyclodextrins vs. the change in the chemical shift f piroxicam indicated that a 1:1 complex was formed.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
12
2
1989
12
31
INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES VIII- FORMULATION OF TABLETS CONTAINING TEMAZEPAM SOLID DISPERSIONS
308
324
72062
10.21608/bfsa.1989.72062
EN
Aly A.
Abdel Rahman
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. E.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
B. A.
Mulley
School of Pharmacy, Bradford University, England
S. M.
Ahmed
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1989
09
18
<em>Temazepam-plyethylene glycol 6000 (PEG 6000) coprecipitates has been formulated as tablets using direct compression technique. This coprecipitation was chosen as it exhibited an optimum drug release characteristic and could be easily handled and pulverized.</em>
<em>Differential scanning calorimetery (DSC) was utilizes to check the compatibility of Temazepam with Avicel pH 101and magnesium stearate as well as the effect of ageing on the formulated coprecipitates, at different storage conditions. It was concluded that the drug is compatible with those tablet excipients, and n detectable change resulted from ageing.</em>
<em>Compression of the formula containing 1:3 w/w Temazepam-PEG 6000 coprecipitates produced good quality tablets having rapid disintegration and rapid dissolution rates. Tablets of 1:7 w/w ratio were highly compact and having a lower disintegration and a lower dissolution rates. This shows the importance of optimizing the formulations by finding out the correct quantity of excipients to maintain better dissolution properties.</em>
<em>The results obtained indicated that 1:3 w/w Temazepam-PEG 6000 coprecipitates retains its higher dissolution when compressed as tablets. Additionally, this tablets formulation helped t provide Temazepam in a high quality dosage form.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
12
2
1989
12
31
PHYTOCHEMICAL STUDY OF CASSIA SPECTABILIS DC. CULTIVATED IN EGYPT
325
338
72063
10.21608/bfsa.1989.72063
EN
S. M.
El-Sayyad
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. M.
Abdel-Baky
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M. A.
El-Shanawany
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Kh. M.
El-Ghandakly
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1989
10
05
<em>Two aliphatic hydrocarbons, anthraquinone (physcion). </em><em>b</em><em>-sitosterol, four flavonoids (apigenin, luteolin, apigenin-7-O-glucoside and 5,7,8,4'-pentahydroxy flavone-6-O-8-O-diglucoside) and the piperidine alkaloids [2-methyl-3-hydroxy-6-dodecyl acetyl piperidine, its isomer and 2-methyl-3-hydroxy-6-(13-tetradecyl acetyl) piperdine] were isolated and identified from the leaves of Cassia spectabilis DC. The identity was accomplished through physical, chemical and spectral studies.</em>