Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3
1
1980
12
31
PHYTOCHEMICAL STUDY OF ARTEMISIA ARGENTEA L'HER
1
8
104596
10.21608/bfsa.1980.104596
EN
A. M.
El-Moghazy
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
N. A.
El-Emary
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1970
01
01
<em>From the alcoholic extract of the defatted powdered aerial parts of the flowering plant, six flavonoid glycosides have been isolated together with large amounts of sucrose and sodium chloride. Four glycosides were hydrolysed and their aglycones were identified as 3,6,7-trimethoxy-4',5'-dihydroxyflavone (penduletin); kaempferol-6-methyl ether; 5,7-dihydroxy-4'-5'-dimethoxyflavone (diosmetin) and kaempferol-6,7-dimethylether. The other two glycosides were minors and un-identified, but spectroscopic data are given. The sugar parts of the identified four glycosides were, glucosyl, arabinosyl, glucosyl and rhamnosyl respectively as identified by paper chromatography and TLC against authentic carbohydrates.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3
1
1980
12
31
PHYTOCHEMICAL STUDIES ON JASMINIUM MESNYI HEMSIL
9
15
104597
10.21608/bfsa.1980.104597
EN
A. M.
El-Moghazy
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. A.
Ali
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S. A.
Ross
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. A.
Mohamed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1970
01
01
<em>Ceryl alcohol, </em><em>a</em><em>-amyrin, </em><em>b</em><em>-sitosterol, Ursolic acid, mannitol, quercetin, flavonol rutin and bitter glucoside jasminin were isolated from the leaves of J. mesnyi, Hemsil. Arachidic and, arachidonic acids are the most prominent fatty acids present in the soap fraction of the petroleum-ether extract. The percentages of rutin as well as total flavonoids in the leaves were determined to be 2.58 and 2.95 g% W/W respection.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3
1
1980
12
31
FLAVONOIDS FROM THE FLOWERS OF LIMONIUM SINUATUM MILL GROWING IN EGYPT
16
24
104709
10.21608/bfsa.1980.104709
EN
S. A.
Ross
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
D. W.
Bishay
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1970
01
01
<em>From the flowers of Limonium sinuatum Mill Family Plumbaginaceae two flavonol glucosides were isolated. Their structures were established by physical, chemical and spectral methods (UV, IR, NMR and Mass) and proved to be:</em>
<em>5,7,4'-trihydroxuflavonol-8-o-glucopyranoside; 5,7,3',4'-tetrahydroxyflavonal-8-o-glucopyranoside.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3
1
1980
12
31
STUDIES ON SOME FACTORS AFFECTING STABILITY OF ISONIAZID IN SOLUTIONS. I. EFFECT OF PH-VALUE AND BUFFER SYSTEM
25
40
104710
10.21608/bfsa.1980.104710
EN
S. A.
Ibrahim
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
H. O.
Ammar
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M. G.
Abd-Elmohsen
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1970
01
01
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3
1
1980
12
31
STUDIES ON THE SOLUBILITY OF RIFAMPICIN. II. EFFECT OF SOME AROMATIC MONOCARBOXYLIC ACIDS SODIUM SALTS, NICOTINAMIDE AND ISONIAZID ON THE WATER-SOLUBILITY OF RIFAMPICIN
41
58
104711
10.21608/bfsa.1980.104711
EN
S. A.
Lbrabim
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. A.
Kassem
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
I. A.
Attia
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S. I.
Mohamed
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1970
01
01
<em>The effect of some salts of aromatic monocarboxylic acids namely, sodium benzoate, sodium p-aminolenzoate, sodium salicylate and sodium p-aminosalioylate as well as nicotinamide and isoniazid on the water solubility of rifampicin was investigated. The apparent, water-solubility of rifampicin is augmented markedly in presence of these agents. The solubilizing power of these agents towards rifampicin is highly dependent on the specific type and in most cases proportional to the concentration of the agent, of the salts of the aromatic monocarboxylic acids, sodium p-aminosalicylate showed the highest solubilizing power followed in order by sodium salicylate, sodium p-aminobenzoate and finally sodium benzoate with the least solubilizing power.</em>
<em>Nicotinamide showed higher solubilizing power than that of isoniazid but much less than that of sodium p-aminosalicylate and sodium salicylate. The solubilizing power of isoniazid is greater than that of sodium benzoate and sodium p-aminobenzoate. The spectral pattern of rifampicin showed a change in optical density in presence of these agents which is proportional to the agent used, suggesting a role of molecular interaction between these agents and rifampicin in the solubilization process.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3
1
1980
12
31
EFFECT OF SURFACTANT STRUCTURE ON THE RELEASE OF DEXAMETHAZONE FROM DIFFERENT OINTMENT BASES
59
73
104712
10.21608/bfsa.1980.104712
EN
F. S.
Habib
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. E.
Abotaleb
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
M. A.
Attia
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1970
01
01
<em>The effect of variations in the surfactant molecular Structure and concentration on the release of dexamethazone from different ointment bases, was investigated. It was found that the release of dexamethazone from oil in water emulsion bases increased in the presence of the different hydrophilic non-ionic surfactants used: This may be due to their solubilizing effect on such slightly water soluble solute. The increase in surfactant concentration enhanced the rate of drug released from each base by a special rate, specific for each base. The incorporation of hydrophobic surfactants in the water in oi1, emulsion bases leads also to increase in the amount of drug released. This may be due to the dispersing effect of these surfactants on such a drug.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3
1
1980
12
31
A STUDY ON THE RELATIONSHIP BETWEEN DISINTEGRATION OF DIRECTLY COMPRESSED SULPHADIMIDINE TABLETS AND THEIR PHYSIOLOGICAL AVAILABILITY IN MAN
74
86
104713
10.21608/bfsa.1980.104713
EN
Adel M.
Sakr
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Ahmed E.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Hassan M.
Elsabbagh
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Adel M.
Aly
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1970
01
01
<em> A study was made on the disintegration time and in vivo absorption rate of sulphadimidine tablets prepared by direct compression technique using Celutab (50% w/w) as an excipient. Tablets of greatly different disintegration times were selected for this investigation. Using urinary excretion method, it was shown that there is a relationship between disintegration time and in vivo absorption of sulphadimidine tablets, in that the tablet with faster disintegration time gives a higher absorption as indicated by the excretion rate calculated from the cummulative amount of sulphadimidine excreted.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3
1
1980
12
31
EFFECT OF DIFFERENT ADDITIVES ON THE MICELLAR SOLUBILIZATION OF CHLORAMPHENICOL
87
104
104720
10.21608/bfsa.1980.104720
EN
A. E.
Aboutaleb
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A.
Abdelzaher
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1970
01
01
<em>The effect of different inorganic and organic additives on the solubility of chloramphenicol by non-ionic surfactant solutions was investigated at two different temperatures. The following additives were used namely polyethylene glycol 600, propylene glycol, glycerol, urea and potassium chloride. Urea produced a slight effect on the solubilizing efficiency of the non-ionic surfactant solutions; on the other hand a more pronounced effect on the solubilizing efficiency of these nonionic micelles was obtained by increasing the concentration of potassium chloride in solutions. For organic additives it was found that the addition of polyethylene glycol 600 increased the solubilizing efficiency of all the non-ionic surfactant solutions than both glycerol and propylene glycol.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3
1
1980
12
31
SENSITIVE AND SPECIFIC ASSAY OF TERTIARY AMINE DRUGS WITH PHTHALIC ANHYDRIDE
105
115
104721
10.21608/bfsa.1980.104721
EN
Aly M.
Taha
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut
S. R.
El-Shabouri
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut
A. I.
Rageh
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut
Journal Article
1970
01
01
<em>The reaction of tertiary amines with phthalic anhydride/acetic anhydride mixture was studied and developed into a sensitive assay for the amines. The method is based on the condensation of the two anhydrides under the catalytic effect of the tertiary amine function, either free or in the form of a salt. The condensation product had a </em><em>l</em><em><sub>max</sub></em><em> at 302 nm for all the drugs tested with apparent molar absorptivitis in the range 5.79 x 10<sup>4</sup>- 1.08 x 10<sup>5</sup>. Absorption Versus concentration was found linear up to about 6 mcg/ml for all drugs studied. The method has been applied for the analysis of certain tertiary amine drugs belonging to different pharmacological groups e.g. pilocarpine nitrate, butethamat citrate, atropine sulphate, bietamiverine dihydrochloride, codeine phosphate and toclase citrate in pure form as well as in pharmaceutical preparations without prior separation and with good accuracy (100 38%), recoveries and precision (SD </em><em>±</em><em> 0.41).</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3
1
1980
12
31
QUINAZOLINONE DERIVATIVES OF BIOLOGICAL INTEREST. II. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CERTAIN 3-ARYL-2-(-ARYLSULPHONYLHYDRAZINOMETHY-4(3H)-QUINAZOLINONES
116
124
104722
10.21608/bfsa.1980.104722
EN
A. M.
Abdel-Aleem
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. F.
Abdel-Ghaffer
Department of Microbiology, Faculty of Medicine, Assiut University, Assiut, Egypt
Journal Article
1970
01
01
<em>Twenty five new quinazolinone derivatives were synthesized. Structure of these compounds was established by microanalysis, UV and IR spectrometry, Antibacterial activity of the prepared compounds was determined in comparison to sulphanilamide against four microorganisms. Fifteen compounds exhibited measurable antibacterial activity especially towards Staph. aureus.</em>
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
3
1
1980
12
31
RAPID, SENSITIVE COLORIMETRIC ASSAY FOR ISOPRENALINE
125
136
104723
10.21608/bfsa.1980.104723
EN
Salwa R.
El-Shabouri
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S. A.
Ibrahim
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
1970
01
01
<em>A simple, rapid, selective and highly sensitive colorimetric method for the determination of isoprenaline (isoproterenol) is described. The method depends on the interaction of dimethoxydiquinone, with isoprenaline sulphate under specified conditions with the formation of a highly coloured, product which has a </em><em>l</em><em><sub>max</sub></em><em> at 5l0 nm and apparent molar absorptivity of 3.8x10<sup>6</sup>. Absorbance versus concentration is linear up to 6 mcg/ml. No interference is observed in presense of common pharmaceutical adjuvants. The developed method is applicable with almost complete recovery for assaying isoprenaline in commercial, pharmaceutical dosage forms without prior separation. The proposed method is also recommended as stability indicating assay for oxidative degradation involving the catecholic function of isoprenaline.</em>