Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
38
1
2015
12
01
SOLUBILITY AND DISSOLUTION ENHANCEMENT OF KETOTIFEN BY SOLID DISPERSION TECHNIQUE
1
18
63168
10.21608/bfsa.2015.63168
EN
Fergany A.
Mohamed
Department of Pharmaceutics, Faculty of Pharmacy, Assuit University, Assiut 71526, Egypt
Dina F. M.
Mohamed
Department of Pharmaceutics, Faculty of Pharmacy, Assuit University, Assiut 71526, Egypt
Omnia A. E.
Mahmoud
Department of Pharmaceutics, Faculty of Pharmacy, Assuit University, Assiut 71526, Egypt
Journal Article
2015
03
04
Ketotifen (KT) solid dispersions and physical mixtures were prepared with the objective of solubility and dissolution improvement using Hydroxypropyl-Beta-Cyclodextrin (HP-β-CD), Pluronic 127 (PF-127), Pluronic 68 (PF-68), Polyethylene glycol 6000 (PEG 6000),and Polyethylene glycol 4000 (PEG 4000). The saturation solubility and in-vitro dissolution studies showed remarkable improvement in solubility and drug dissolution of these new solid dispersions and physical mixtures over pure ketotifen. The XRD, DSC, IR and SEM studies indicated the transformation of crystalline ketotifen (in pure drug) to amorphous ketotifen (in solid dispersions). This study concluded that the improved solubility as well as drug dissolution of these new ketotifen solid dispersions may be attributed to improved wettability and reduction in drug crystallinity, which can be modulated by appropriate level of hydrophilic carriers. <br /> <br />
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
38
1
2015
12
01
NIOSOMES AS AN ORAL DRUG DELIVERY SYSTEM CONTAINING TENOXICAM
19
29
63170
10.21608/bfsa.2015.63170
EN
Gamal Abdel Ghany
Shazly
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Kingdom of Saudi Arabia
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
Journal Article
2015
03
19
Niosomes vesicles are microscopic lamellar structures formed by mixing with nonionic surfactant, cholesterol and phosphate in aqueous media. Using niosomes as drug delivery system affords several significant advantages over conventional drug therapy. The main aim of this study was to formulate suitable niosome-encapsulated drug delivery for tenoxicam (antiinflammatory drug) and estimate the percentage encapsulation efficiency, in-vitro release and in-vivo anti-inflammatory effect. Different non-ionic surfactants, cholesterol and different charge inducing agents were used in different molar ratios. Three different methods were used for niosomes preparation. The higher entrapment efficiency was observed with niosomes prepared from span 40, cholesterol and stearylamine in 45:45:10 molar ratios (N11). The invitro release study was found that niosomes exhibiting higher entrapment efficiency showed slower release rate of drug than other formulae. The results of in-vivo study revealed that the niosomes significantly enhanced the anti-inflammatory effect of tenoxicam. The present work concluded that tenoxicam loaded niosomes was effective in sustaining the drug release resulting in diminished side effects and improved patient compliance.
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
38
1
2015
12
01
SYNTHESIS OF SOME NOVEL 1,3,6-TRISUBSTITUTED-1HTHIAZOLO[3,2-f]PURINE-2,4-DIONES AND XANTHINE SCHIFF BASES AS POTENIAL ANTI-ASTHMATIC AND ANTIINFLAMMATORY AGENTS
31
46
63174
10.21608/bfsa.2015.63174
EN
Alaa M.
Hayallah
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, El-Minia, Egypt
Reham Abu
Shmeis
Department of Basic Pharmaceutical Sciences (Analytical Chemistry), Faculty of Pharmacy, Israa University, Amman, Jordan
Ahmad A.
Talhouni
Department of Applied Pharmaceutical Sciences (Pharmacology), Faculty of Pharmacy, Israa University, Amman, Jordan
Journal Article
2015
05
30
In this study, the design, synthesis and preliminary pharmacological investigation of novel 1,3-diethyl-8-disubstituted xantines 12-18, 1,3,6-trisubstituted-1H-thiazolo[3,2-f]purine-2,4diones 19-25 and xanthine Schiff bases 28-33 was described. 1,3-Diethyl-8-substituted xantines 12-18 were prepared by the reaction of 1,3-diethyl-8-thioxo-3,7,8,9-tetrahydropurine-2,6-dione 4 with the appropriate phenacyl bromides 5-11. Compound 4 was in turn prepared by the reaction of 5,6-diamino-1,3-diethyluracil 3 with carbon disulfide. The derivatives 19-25 were obtained by cyclodehydration of compounds 12-18 in polyphosphoric acid (PPA). Schiff bases 28-33 were synthesized by the reaction of acetohydrazide 27 with appropriate aldehyde in refluxed ethanol. The effect of the new derivatives as potential anti-asthmatic was evaluated using acetycholine induced brocnhospasm in Guinea pigs, most of tested compounds showed significant anti-bronchoconstriction activity in comparison with aminophylline as a standard drug. Anti-inflammatory activity of the target compounds was investigated using indomethacin as a reference drug and some compounds exhibited potent anti-inflammatory activity.
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
38
1
2015
12
01
MUCOADHESIVE POLYMERS AS EFFICIENT DRUG DELIVERY SYSTEMS
47
60
63175
10.21608/bfsa.2015.63175
EN
Gamal El-Din A.
El-Gindy
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Mona M.
El-Mahdy
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Ghareb M.
Soliman
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abeer S.
Hassan
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
2015
06
21
The drug action can be reinforced as a result of the development of new drug delivery systems. Over the past few decades, mucosal drug delivery has received a great deal of attention to improve both the local and systemic drug effects. Drug delivery across the mucosa bypasses the first-pass hepatic metabolism and avoids the degradation caused by the gastrointestinal enzymes. Mucoadhesive dosage forms are designed to enable prolonged retention at the desirable site of action, provide sustained release of drug and thus, lead to an improved bioavailability, as well as therapeutic outcomes. Compared with other mucosal tissues, vaginal mucosal cavity is more appropriate and attractive for drug delivery. In addition, a prolonged contact of mucoadhesive dosage forms with the vaginal mucosa may be achieved more easily than at other absorption sites like rectum or intestinal mucosa. This review aims to highlight the recent advances in the study of mucoadhesion and mucoadhesive polymers. It provides an overview of the structure of mucosal membranes, the mechanism and theories involved in mucoadhesion, and finally it describes briefly the main characteristics and the advantages of vaginal mucoadhesive drug delivery systems compared with other delivery systems. <br /> <br />
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
38
1
2015
12
01
IN-VITRO AND IN-VIVO EVALUATION OF SUSTAINED-RELEASE SUPPOSITORIES CONTAINING THEOPHYLLINE MICROSPHERES
91
98
63177
10.21608/bfsa.2015.63177
EN
Gamal M.
Mahrous
Department of Pharmaceutics, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
Gamal A.
Shazly
Department of Pharmaceutics, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University 71526, Assiut, Egypt
Sayed H.
Auda
Department of Pharmaceutics, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy,Al-zhar University, Assiut, Egypt
Hesham M.
Tawfeek
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University 71526, Assiut, Egypt
Journal Article
2015
09
17
The sustained release microspheres of theophylline were formulated using non-solvent addition technique. The in-vitro dissolution of the drug from the fabricated microspheres that having size ranges of 300-600, 600-800 and 800-1000 µm was tested. The release of theophylline was extended over 8 hrs and it was found that the drug release decreased nonsignificantly as the particle size increased (p≥ 0.05). Incorporating theophylline-containing microspheres into suppository formulation using polyethylene glycol base resulted in a slight increase in dissolution rate, but still in a sustained release pattern over 8 hrs. In-vivo study of the prepared suppositories on beagle dogs revealed that the peak of theophylline serum concentration Cmax (mean±S.D) was 11.1+0.3 µg/mL. It was also found that AUC(0–24hrs) value averaged 154.7±20.3 µg-h/ml. The median peak time (Tmax) was 3.0 hrs and MRT was 13 hrs indicating a sustained effect. <br /> <br />
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
38
1
2015
12
01
MACRO-AND MICROMORPHOLOGY OF THE LEAVES, STEM BARK AND FLOWERS OF PUNICA GRANATUM L. VAR. NANA CULTIVATED IN EGYPT
99
125
63178
10.21608/bfsa.2015.63178
EN
A. M.
El-Moghazy
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
A. A.
Khalifa
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
S. A. L.
Bayoumi
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
H. M. B.
Sayed
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Journal Article
2015
10
27
Punica granatum L. var. nana (ornamental pomegranate) belongs to family Punicaceae. It is popularly planted in gardens for ornament. The root, stem bark and to a lesser extent fruit rind of the edible pomegranate had been commonly used as a vermifugal or taenicidal agent on tapeworms. By reviewing the literature, no botanical studies were done on Punica grantum L. var. nana, so this study aims for characterization and identification of this plant in both entire and powdered forms. <br /> <br />
Assiut University, Faculty of Pharmacy
Bulletin of Pharmaceutical Sciences Assiut University
1110-0052
38
1
2015
12
01
BOTANICAL STUDY AND DNA FINGERPRINT OF CEIBA PENTANDRA (L.) GAERTN. VAR. PENTANDRA CULTIVATED IN EGYPT
61
90
63180
10.21608/bfsa.2015.63180
EN
Faten M. M.
Darwish
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Mohamed A. A.
Orabi
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut, Egypt
Mohamed S. A.
Abdelkader
Department of Pharmacognosy, Faculty of Pharmacy, Sohag University, Nasr City, Eastern Avenue, Sohag, Egypt
Mohamed E.
Abou-Elela
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut, Egypt
Journal Article
2015
09
16
Ceiba pentandra (L.) Gaertn. (kapok) (F: Bombacaceae) is a large, fast growing tree of up to 50 m height. It grows naturally in the tropical and subtropical regions of the world and planted as a shade tree. In traditional medicine, it is mainly used as an emetic, diuretic and antispasmodic agent. Extracts of different morphological parts of the plant has been also recommended for the treatment of various ailments, include diabetes, bronchitis, skin diseases, diarrhea, dysentery, eye diseases, arthritis, insect bite and chronic fever. There are at least four common varieties of Ceiba pentandra species include; var. caribaea (DC.) Bakh., var. guineensis (Schumach. & Thonn.) H. G. Baker, var. pentandra and var. indica Bakhuisen. However, there were no specific identification standards for such varieties in the previous researches. In this study, a detailed description for the morphological and anatomical characters of the leaves, stems and fruits of Ceiba pentandra var. pentandra is performed. Additionally, the DNA fingerprint of the variety pentandra was established to help in its future identification at the genomic level. <br /> <br />