Stearic acid was used for the preparation of solid dispersion systems containing sodium Phanobarbitone in ratios of 1:2,1:1, 2:1 drug: carrier respectively. The dispersion prepared by melting and sudden cooling was passed through a set of standard sieves and tested for in vitro release rate. The release was slow for large particle size fractions and for systems containing high stearic acid content. A diffusional model was assessed for the drug release from the solid dispersion by a linear correlation observed between the percent release of the drug and the square root of time.
Nouh, A., & Mesiha, M. (1983). THE PROLONGED RELEASE OF SODIUM PHENOBARBITONE FROM SOLID DISPERSION SYSTEM. Bulletin of Pharmaceutical Sciences Assiut University, 6(1), 81-88. doi: 10.21608/bfsa.1983.100715
MLA
A. T. Nouh; M. S. Mesiha. "THE PROLONGED RELEASE OF SODIUM PHENOBARBITONE FROM SOLID DISPERSION SYSTEM". Bulletin of Pharmaceutical Sciences Assiut University, 6, 1, 1983, 81-88. doi: 10.21608/bfsa.1983.100715
HARVARD
Nouh, A., Mesiha, M. (1983). 'THE PROLONGED RELEASE OF SODIUM PHENOBARBITONE FROM SOLID DISPERSION SYSTEM', Bulletin of Pharmaceutical Sciences Assiut University, 6(1), pp. 81-88. doi: 10.21608/bfsa.1983.100715
VANCOUVER
Nouh, A., Mesiha, M. THE PROLONGED RELEASE OF SODIUM PHENOBARBITONE FROM SOLID DISPERSION SYSTEM. Bulletin of Pharmaceutical Sciences Assiut University, 1983; 6(1): 81-88. doi: 10.21608/bfsa.1983.100715
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