Document Type : Original Article
Authors
1
Department of Pharmaceutics, Faculty of Pharmacy, El-Azhar University, Nasr City, Cairo, Egypt
2
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
3
The National Organization for Drug Control and Research, Giza, Egypt
4
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
Abstract
Kanamycin and gentamicin ointments were prepared using four different ointment bases, namely oleaginous, absorption, emulsion and water-soluble bases. Glyaerol, Propylene glyaol, polyethylene glycols 200, 400, 600 and 1000, water, alcohol, dimethylformamide, dimethylsulfoxide and polysorbate 80 were separately incorporated at 10% concentration into all the ointments prepared. The effect of all these additives on the antimicrobial activity of gentamicin and kanamycin was investigated.
Water-soluble base was found to be the best for preparing kanamycin and gentamicin ointments. Of the additives tested, glycerol, dimethylformamide dimethylsulfoxide and polysorbate 80 proved to have more effect in increasing the activity of kanamycin than the other additives. while for gentamicin, the best effect was with either glycerol, propylene glycol or polyethylene glycol in water soluble base, and with 10% water in oleaginous base.
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