SOLUBILIZATION OF CARBAMAZEPINE USING HYDROTROPIC AGENTS

Document Type : Original Article

Authors

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Abstract

The effect of number of hydrotropic agents be longing to diverse chemical groups, e.g. sugars, sugar alcohols, amides, imides, acids and salts, on the water-solubility of the practically insoluble antiepileptic drug Carbamazepine at 25° was studied. Also, comparison of the solubilizing efficiency of the different hydrotropic agents was performed. It is clearly evident that the solubilizing efficiency of these hydrotropic agents depends upon both type and concentration of the tested additives used in this study.