FORMULATION AND IN-VITRO EVALUATION OF RIBOFLAVIN TABLETS PREPARED BY FLUIDIZED BED GRANULATION TECHNIQUE

Kassem, M. A. A.; Nouh, A. T.; El-Bayomy, T.; Kassem, Alaa A. A.

doi:10.21608/bfsa.1983.102097

FORMULATION AND IN-VITRO EVALUATION OF RIBOFLAVIN TABLETS PREPARED BY FLUIDIZED BED GRANULATION TECHNIQUE

Document Type : Original Article

Authors

¹ Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

² Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

³ National Organization for Drug and Research, Giza, Egypt

⁴ Department of Pharmaceutics, Faculty of Pharmacy, El-Azhr University, Nasr City, Cairo, Egypt

10.21608/bfsa.1983.102097

Abstract

Spray granulation technique using fluidized bed was used for preparing riboflavin granules. Five binders were used for granulation as spray liquids, Polyvinylpyrrolidone proved to be the most suitable binder followed by sodium alginate and sodium carboxy methyl cellulose. Methyl cellulose produced tablets which disintegrated within the U.S.P.XX. Limit, but of low dissolution rate; while ethyl cellulose gave tablets which did not conform to the official Limit, but the drug was released from the tablet matrix faster than from tablets prepared by methyl cellulose.