EFFECT OF CERTAIN OPHTHALMIC PREPARATIONS CONTAINING PILOCARPINE HYDROCHLORIDE AND DEXAMETHASONE ON THE INTRAOCULAR PRESSURE OF RABBITS EYE

Document Type : Original Article

Authors

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Abstract

The present study deals with the influence of dexamethasone applied locally on the intraocular pressure (I.O.P.) of rabbit and how far this influence may be corrected by the use of the antiglaucoma drug pilocarpine hydrochloride.
 It was found that no change in pupillary diameter occurs after instillation of dexamethasone solution. A slight increase in the miotic activity of pilocarpine hydrochloride combined with dexamethasone was observed 15 minutes post-instillation, reaching to maximum within 2-3 hours and then extending to 24 hours.
Dexamethasone plus pilocarpine hydrochloride in a w/o emulsion base produced the highest effect after 2-3 hours. The I.O.P. reached to the initial level, 24 hours after application. The ointment seems to form over the corneal surface, an occlusive nonrenewable film, from which pilocarpine hydrochloride is depleted from its aqueous phase. On the other hand dexamethasone lipid solubility permits slow diffusion through the vehicle to replenish the concentration of drug in the film adjacent to the corneal surface. For this reason, the I.O.P did not return to its initial level.

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