STUDIES ON THE SOLUBILITY OF RIFAMPICIN. II. EFFECT OF SOME AROMATIC MONOCARBOXYLIC ACIDS SODIUM SALTS, NICOTINAMIDE AND ISONIAZID ON THE WATER-SOLUBILITY OF RIFAMPICIN

Document Type : Original Article

Authors

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Abstract

The effect of some salts of aromatic monocarboxylic acids namely, sodium benzoate, sodium p-aminolenzoate, sodium salicylate and sodium p-aminosalioylate as well as nicotinamide and isoniazid on the water solubility of rifampicin was investigated. The apparent, water-solubility of rifampicin is augmented markedly in presence of these agents. The solubilizing power of these agents towards rifampicin is highly dependent on the specific type and in most cases proportional to the concentration of the agent, of the salts of the aromatic monocarboxylic acids, sodium p-aminosalicylate showed the highest solubilizing power followed in order by sodium salicylate, sodium p-aminobenzoate and finally sodium benzoate with the least solubilizing power.
Nicotinamide showed higher solubilizing power than that of isoniazid but much less than that of sodium p-aminosalicylate and sodium salicylate. The solubilizing power of isoniazid is greater than that of sodium benzoate and sodium p-aminobenzoate. The spectral pattern of rifampicin showed a change in optical density in presence of these agents which is proportional to the agent used, suggesting a role of molecular interaction between these agents and rifampicin in the solubilization process.

Files

Share

How to cite

Statistics