QUINAZOLINONE DERIVATIVES OF BIOLOGICAL INTEREST. II. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CERTAIN 3-ARYL-2-(-ARYLSULPHONYLHYDRAZINOMETHY-4(3H)-QUINAZOLINONES

Document Type : Original Article

Authors

1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

2 Department of Microbiology, Faculty of Medicine, Assiut University, Assiut, Egypt

Abstract

Twenty five new quinazolinone derivatives were synthesized. Structure of these compounds was established by microanalysis, UV and IR spectrometry, Antibacterial activity of the prepared compounds was determined in comparison to sulphanilamide against four microorganisms. Fifteen compounds exhibited measurable antibacterial activity especially towards Staph. aureus.