A simple, rapid, selective and highly sensitive colorimetric method for the determination of isoprenaline (isoproterenol) is described. The method depends on the interaction of dimethoxydiquinone, with isoprenaline sulphate under specified conditions with the formation of a highly coloured, product which has a lmax at 5l0 nm and apparent molar absorptivity of 3.8x106. Absorbance versus concentration is linear up to 6 mcg/ml. No interference is observed in presense of common pharmaceutical adjuvants. The developed method is applicable with almost complete recovery for assaying isoprenaline in commercial, pharmaceutical dosage forms without prior separation. The proposed method is also recommended as stability indicating assay for oxidative degradation involving the catecholic function of isoprenaline.
El-Shabouri, S., & Ibrahim, S. (1980). RAPID, SENSITIVE COLORIMETRIC ASSAY FOR ISOPRENALINE. Bulletin of Pharmaceutical Sciences Assiut University, 3(1), 125-136. doi: 10.21608/bfsa.1980.104723
MLA
Salwa R. El-Shabouri; S. A. Ibrahim. "RAPID, SENSITIVE COLORIMETRIC ASSAY FOR ISOPRENALINE". Bulletin of Pharmaceutical Sciences Assiut University, 3, 1, 1980, 125-136. doi: 10.21608/bfsa.1980.104723
HARVARD
El-Shabouri, S., Ibrahim, S. (1980). 'RAPID, SENSITIVE COLORIMETRIC ASSAY FOR ISOPRENALINE', Bulletin of Pharmaceutical Sciences Assiut University, 3(1), pp. 125-136. doi: 10.21608/bfsa.1980.104723
VANCOUVER
El-Shabouri, S., Ibrahim, S. RAPID, SENSITIVE COLORIMETRIC ASSAY FOR ISOPRENALINE. Bulletin of Pharmaceutical Sciences Assiut University, 1980; 3(1): 125-136. doi: 10.21608/bfsa.1980.104723
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