Document Type : Original Article
Authors
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
The effect of a number of water-miscible co-solvents namely; glycerin, glycerin formal, propylene glycol, polyethylene glycol; 200, 300, and 400 polypropylene 420, dimethylformamide and dimethyl sulfoxid in various concentrations up to 50% with water, as well a number of nonionic surfactants namely; tween 20, tween 40, tween 60 and tween 80 in various concentrations up to 10% in water, on the equilibrium solubility of rifampicin was evaluated. It was found that the solubility of rifampicin is promoted to a marked extent in presence of the co-solvents and the nonionic surfactants. However, the extent of the solubility-promoting effect was dependent on the type and concentration of the co-solvent and the surfactant used. Presence of 50% co-solvents with water increased the solubility of rifampicin to 1.15, 1.2, 1.5, 6, 9, 14, 14.6, 60 and 121.3 times its original water-solubility in cases of; propylene glycol, glycerin-formal, glycerin, polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, dimethyl sulfoxide, polypropylene glycol 420 and dimethylformamide respectively. A 10% surfactant concentration in water, increased the solubility of rifampicin to 9.6, 8.52, 7.74 and 7.35 times its original water solubility in cases of tween20, tween 40, tween 80 and tween 60 respectively.
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