COLORIMETRIC DETERMINATION OF CERTAIN SYMPATHOMIMETIC DRUGS

Document Type : Original Article

Author

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Abstract

A rapid, simple and highly sensitive spectrophotometric method for the determination of oxiderine tartrate, etilefrine hydrochloride, metaraminol bitartrate, orciprenaline sulphate and isoprenaline sulphate is described. The method depends on the reaction of aqueous solution of these drugs with the diazotized 5-chloro-2,4-dinitroaniline in alkaline medium to give a highly coloured product with characteristic lmax for each drug in the range of 420-550 nm. The colour produced in all cases obeys Beer's law. This method is suitable for the analysis of these drugs in pure forms and in pharmaceutical preparations without prior separation.