The present study was aimed at evaluating the anti-inflammatory action and toxicity of seven N-[-l-(p-nitrophenyl)-l,3-dihydroxy isopropyl]-N'-(substituted) oxamides (1). The compounds are designed to include the following moieties: anthranilic and p-aminosalicylic acids and p-aminophenol in their basic structures. Two dose levels of these compounds were assessed for their anti--inflammatory property in rate by the trypan blue method and using acetyl salicylic acid as the reference anti-inflammatory agent. Median lethal doses of the compounds were determined in mice. The possible correlation between structure and biological activity is suggested.
El-Koussi, A., Abdel-Aleem, A., & Afifi, A. (1978). ANTI-INFLAMMATORY ACTION AND TOXICITY OF CERTAIN OXAMIDE DERIVATIVES. Bulletin of Pharmaceutical Sciences Assiut University, 1(1), 151-161. doi: 10.21608/bfsa.1978.104913
MLA
A. A. El-Koussi; A. M. Abdel-Aleem; A. M. Afifi. "ANTI-INFLAMMATORY ACTION AND TOXICITY OF CERTAIN OXAMIDE DERIVATIVES", Bulletin of Pharmaceutical Sciences Assiut University, 1, 1, 1978, 151-161. doi: 10.21608/bfsa.1978.104913
HARVARD
El-Koussi, A., Abdel-Aleem, A., Afifi, A. (1978). 'ANTI-INFLAMMATORY ACTION AND TOXICITY OF CERTAIN OXAMIDE DERIVATIVES', Bulletin of Pharmaceutical Sciences Assiut University, 1(1), pp. 151-161. doi: 10.21608/bfsa.1978.104913
VANCOUVER
El-Koussi, A., Abdel-Aleem, A., Afifi, A. ANTI-INFLAMMATORY ACTION AND TOXICITY OF CERTAIN OXAMIDE DERIVATIVES. Bulletin of Pharmaceutical Sciences Assiut University, 1978; 1(1): 151-161. doi: 10.21608/bfsa.1978.104913
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