A spectrophotometric method is described for the determination of some N-ethyl drugs via reaction with chloranil. A mixture of a solution of' the amine in benzene with the chromogenic reagent was heated on a water bath at 75-80° for one hour. A blue colored product lmax 680 nm resulted. Apparent molar absorptivities of the chromogenic product of tertiary N-ethyl compounds ranged from 1700-5100. Under the described assay conditions N-methyl as well as quaternized N-ethyl compounds did not interfere. The amines are asseyed in the range of 0.004 - 1.3 mg per ml range with an accuracy of 99-101% recovery and a S.D. of ± 0.74- ± 3.11.%. The possible composition of the colored product is discussed.
Abdelkader, M., & Taha, A. (1978). SENSITIVE AND SPECIFIC PHOTOMETRIC DETERMINATION OF N-ETHYL DRUGS. Bulletin of Pharmaceutical Sciences Assiut University, 1(1), 163-174. doi: 10.21608/bfsa.1978.104914
MLA
M. Atef Abdelkader; Aly M. Taha. "SENSITIVE AND SPECIFIC PHOTOMETRIC DETERMINATION OF N-ETHYL DRUGS". Bulletin of Pharmaceutical Sciences Assiut University, 1, 1, 1978, 163-174. doi: 10.21608/bfsa.1978.104914
HARVARD
Abdelkader, M., Taha, A. (1978). 'SENSITIVE AND SPECIFIC PHOTOMETRIC DETERMINATION OF N-ETHYL DRUGS', Bulletin of Pharmaceutical Sciences Assiut University, 1(1), pp. 163-174. doi: 10.21608/bfsa.1978.104914
VANCOUVER
Abdelkader, M., Taha, A. SENSITIVE AND SPECIFIC PHOTOMETRIC DETERMINATION OF N-ETHYL DRUGS. Bulletin of Pharmaceutical Sciences Assiut University, 1978; 1(1): 163-174. doi: 10.21608/bfsa.1978.104914
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