SYNTHESIS AND PHARMACOLOGICAL SCREENING OF CERTAIN IMIDAZOQUINAZOLONE DERIVATIVES

Document Type : Original Article

Authors

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Egypt

Abstract

Certain imidazoquinazolin-5(4H)-one derivatives have been synthesized by replacement of the 4-amino group compound I with different moieties of expected biological activity.
Representative example of the synthesized compounds were tested for their anti-inflammatory, analgesic, antipyretic and anticonvulsant activities. Certain derivatives showed activities higher than that of the reference drugs.